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- Publisher Website: 10.1073/pnas.1011688108
- Scopus: eid_2-s2.0-79957777311
- PMID: 21571641
- WOS: WOS:000290908000016
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Article: Imaging the electromechanical activity of the heart in vivo
Title | Imaging the electromechanical activity of the heart in vivo |
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Authors | |
Keywords | Electromechanical coupling Strain |
Issue Date | 2011 |
Publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org |
Citation | Proceedings Of The National Academy Of Sciences Of The United States Of America, 2011, v. 108 n. 21, p. 8565-8570 How to Cite? |
Abstract | Cardiac conduction abnormalities remain a major cause of death and disability worldwide. However, as of today, there is no standard clinical imaging modality that can noninvasively provide maps of the electrical activation. In this paper, electromechanical wave imaging (EWI), a novel ultrasound-based imaging method, is shown to be capable of mapping the electromechanics of all four cardiac chambers at high temporal and spatial resolutions and a precision previously unobtainable in a full cardiac view in both animals and humans. The transient deformations resulting from the electrical activation of the myocardium were mapped in 2D and combined in 3D biplane ventricular views. EWI maps were acquired during five distinct conduction configurations and were found to be closely correlated to the electrical activation sequences. EWI in humans was shown to be feasible and capable of depicting the normal electromechanical activation sequence of both atria and ventricles. This validation of EWI as a direct, noninvasive, and highly translational approach underlines its potential to serve as a unique imaging tool for the early detection, diagnosis, and treatment monitoring of arrhythmias through ultrasoundbased mapping of the transmural electromechanical activation sequence reliably at the point of care, and in real time. |
Persistent Identifier | http://hdl.handle.net/10722/167062 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Provost, J | en_US |
dc.contributor.author | Lee, WN | en_US |
dc.contributor.author | Fujikura, K | en_US |
dc.contributor.author | Konofagou, EE | en_US |
dc.date.accessioned | 2012-09-28T04:02:27Z | - |
dc.date.available | 2012-09-28T04:02:27Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Proceedings Of The National Academy Of Sciences Of The United States Of America, 2011, v. 108 n. 21, p. 8565-8570 | en_US |
dc.identifier.issn | 0027-8424 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/167062 | - |
dc.description.abstract | Cardiac conduction abnormalities remain a major cause of death and disability worldwide. However, as of today, there is no standard clinical imaging modality that can noninvasively provide maps of the electrical activation. In this paper, electromechanical wave imaging (EWI), a novel ultrasound-based imaging method, is shown to be capable of mapping the electromechanics of all four cardiac chambers at high temporal and spatial resolutions and a precision previously unobtainable in a full cardiac view in both animals and humans. The transient deformations resulting from the electrical activation of the myocardium were mapped in 2D and combined in 3D biplane ventricular views. EWI maps were acquired during five distinct conduction configurations and were found to be closely correlated to the electrical activation sequences. EWI in humans was shown to be feasible and capable of depicting the normal electromechanical activation sequence of both atria and ventricles. This validation of EWI as a direct, noninvasive, and highly translational approach underlines its potential to serve as a unique imaging tool for the early detection, diagnosis, and treatment monitoring of arrhythmias through ultrasoundbased mapping of the transmural electromechanical activation sequence reliably at the point of care, and in real time. | en_US |
dc.language | eng | en_US |
dc.publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org | en_US |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | en_US |
dc.subject | Electromechanical coupling | - |
dc.subject | Strain | - |
dc.subject.mesh | Diagnostic Imaging - Methods | en_US |
dc.subject.mesh | Electrophysiologic Techniques, Cardiac - Methods | en_US |
dc.subject.mesh | Heart Conduction System - Physiology - Ultrasonography | en_US |
dc.subject.mesh | Heart Ventricles - Ultrasonography | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Models, Cardiovascular | en_US |
dc.subject.mesh | Ventricular Function | en_US |
dc.title | Imaging the electromechanical activity of the heart in vivo | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, WN: wnlee@hku.hk | en_US |
dc.identifier.authority | Lee, WN=rp01663 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1073/pnas.1011688108 | en_US |
dc.identifier.pmid | 21571641 | - |
dc.identifier.scopus | eid_2-s2.0-79957777311 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79957777311&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 108 | en_US |
dc.identifier.issue | 21 | en_US |
dc.identifier.spage | 8565 | en_US |
dc.identifier.epage | 8570 | en_US |
dc.identifier.isi | WOS:000290908000016 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Provost, J=7103236841 | en_US |
dc.identifier.scopusauthorid | Lee, WN=51964186500 | en_US |
dc.identifier.scopusauthorid | Fujikura, K=7004375160 | en_US |
dc.identifier.scopusauthorid | Konofagou, EE=7005877325 | en_US |
dc.identifier.issnl | 0027-8424 | - |