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Article: Humoral antibody response after receipt of inactivated seasonal influenza vaccinations one year apart in children

TitleHumoral antibody response after receipt of inactivated seasonal influenza vaccinations one year apart in children
Authors
Keywordschildren
influenza
vaccination
Issue Date2012
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pidj.com
Citation
Pediatric Infectious Disease Journal, 2012, v. 31 n. 9, p. 964-969 How to Cite?
AbstractBackground: Annual vaccination against seasonal influenza viruses is recommended for school-age children in some countries. There are limited data on the immunogenicity and efficacy of repeated influenza vaccinations. Methods: In a randomized controlled trial, we administered seasonal trivalent inactivated influenza vaccine (TIV) or placebo to 64 children 6-15 years of age in two consecutive years and explored their humoral antibody responses. Results: Receipt of TIV in the first year was associated with lower antibody titer rises in the second year to seasonal influenza A(H1N1) and A(H3N2) strains for which the vaccine strains remained unchanged. Antibody response to a different influenza B strain in the second year was unaffected by receipt of TIV in the first year. Children who received TIV in both years showed higher antibody titers against pandemic A(H1N1) which was not included in either TIV. Conclusions: Results from our study suggest that humoral antibody response to TIV may be lower in children receiving repeated vaccination, but receipt of TIV induced seroprotection in most subjects. Our study was underpowered to explore whether differences in immunogenicity translated to differences in vaccine efficacy. © 2012 by Lippincott Williams and Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/166780
ISSN
2015 Impact Factor: 2.587
2015 SCImago Journal Rankings: 1.416
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, Sen_HK
dc.contributor.authorFang, VJen_HK
dc.contributor.authorIp, DKMen_HK
dc.contributor.authorChiu, SSen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorCowling, BJen_HK
dc.date.accessioned2012-09-20T08:48:03Z-
dc.date.available2012-09-20T08:48:03Z-
dc.date.issued2012en_HK
dc.identifier.citationPediatric Infectious Disease Journal, 2012, v. 31 n. 9, p. 964-969en_HK
dc.identifier.issn0891-3668en_HK
dc.identifier.urihttp://hdl.handle.net/10722/166780-
dc.description.abstractBackground: Annual vaccination against seasonal influenza viruses is recommended for school-age children in some countries. There are limited data on the immunogenicity and efficacy of repeated influenza vaccinations. Methods: In a randomized controlled trial, we administered seasonal trivalent inactivated influenza vaccine (TIV) or placebo to 64 children 6-15 years of age in two consecutive years and explored their humoral antibody responses. Results: Receipt of TIV in the first year was associated with lower antibody titer rises in the second year to seasonal influenza A(H1N1) and A(H3N2) strains for which the vaccine strains remained unchanged. Antibody response to a different influenza B strain in the second year was unaffected by receipt of TIV in the first year. Children who received TIV in both years showed higher antibody titers against pandemic A(H1N1) which was not included in either TIV. Conclusions: Results from our study suggest that humoral antibody response to TIV may be lower in children receiving repeated vaccination, but receipt of TIV induced seroprotection in most subjects. Our study was underpowered to explore whether differences in immunogenicity translated to differences in vaccine efficacy. © 2012 by Lippincott Williams and Wilkins.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pidj.comen_HK
dc.relation.ispartofPediatric Infectious Disease Journalen_HK
dc.subjectchildrenen_HK
dc.subjectinfluenzaen_HK
dc.subjectvaccinationen_HK
dc.titleHumoral antibody response after receipt of inactivated seasonal influenza vaccinations one year apart in childrenen_HK
dc.typeArticleen_HK
dc.identifier.emailIp, DKM: dkmip@hku.hken_HK
dc.identifier.emailChiu, SS: ssschiu@hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailCowling, BJ: bcowling@hku.hken_HK
dc.identifier.authorityIp, DKM=rp00256en_HK
dc.identifier.authorityChiu, SS=rp00421en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityCowling, BJ=rp01326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/INF.0b013e318263280een_HK
dc.identifier.pmid22683675-
dc.identifier.pmcidPMC3422369-
dc.identifier.scopuseid_2-s2.0-84865500116en_HK
dc.identifier.hkuros208336en_US
dc.identifier.hkuros207984-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84865500116&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue9en_HK
dc.identifier.spage964en_HK
dc.identifier.epage969en_HK
dc.identifier.isiWOS:000308197200023-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f1000717952624-
dc.identifier.scopusauthoridNg, S=55241586000en_HK
dc.identifier.scopusauthoridFang, VJ=24474130400en_HK
dc.identifier.scopusauthoridIp, DKM=35117701600en_HK
dc.identifier.scopusauthoridChiu, SS=7202291500en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridCowling, BJ=8644765500en_HK

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