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Article: Characterization of a novel gyrovirus in human stool and chicken meat

TitleCharacterization of a novel gyrovirus in human stool and chicken meat
Authors
KeywordsVirus DNA
Chicken meat
Diarrhea
Feces analysis
Gyrovirus
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
Citation
Journal of Clinical Virology, 2012, v. 55 n. 3, p. 209-213 How to Cite?
AbstractBACKGROUND: Sequence-independent amplification of clinical specimens can lead to the identification of novel pathogens. OBJECTIVES: To identify novel viruses in human stool specimens from patients with diarrhea and to investigate the ecology and clinical significance of such viruses. STUDY DESIGN: Nucleic acid extracted from stool specimens from patients with diarrhea with no known etiology were subjected to random PCR amplification and Roche/454 pyrosequencing. Novel viruses identified were genetically and epidemiologically characterized. RESULTS: Four gyroviruses, chicken anemia virus (CAV), human gyrovirus (HGV)/avian gyrovirus 2 (AGV2), gyrovirus 3 (GyV3) and a novel gyrovirus (tentatively designated as gyrovirus 4 (GyV4)) were identified in human stool specimens. GyV4, as well as CAV and AGV2/HGV were also detected in chicken skin and meat used for human consumption. CONCLUSIONS: A novel gyrovirus (GyV4) was identified in human stool and in chicken meat sold for human consumption. This virus was phylogenetically distinct from previously reported gyroviruses in chicken and humans (chicken anemia virus, human gyrovirus, avian gyrovirus 2 and recently reported gyrovirus 3). The epidemiology and pathogenesis of this virus in humans and in chicken needs to be further investigated.
Persistent Identifierhttp://hdl.handle.net/10722/166779
ISSN
2014 Impact Factor: 3.016
2014 SCImago Journal Rankings: 1.284
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, DKWen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorChiu, SSSen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorNg, EMen_HK
dc.contributor.authorBauer, Ien_HK
dc.contributor.authorCheung, TKen_HK
dc.contributor.authorNg, IHYen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorWang, Den_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2012-09-20T08:48:03Z-
dc.date.available2012-09-20T08:48:03Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal of Clinical Virology, 2012, v. 55 n. 3, p. 209-213en_HK
dc.identifier.issn1386-6532en_HK
dc.identifier.urihttp://hdl.handle.net/10722/166779-
dc.description.abstractBACKGROUND: Sequence-independent amplification of clinical specimens can lead to the identification of novel pathogens. OBJECTIVES: To identify novel viruses in human stool specimens from patients with diarrhea and to investigate the ecology and clinical significance of such viruses. STUDY DESIGN: Nucleic acid extracted from stool specimens from patients with diarrhea with no known etiology were subjected to random PCR amplification and Roche/454 pyrosequencing. Novel viruses identified were genetically and epidemiologically characterized. RESULTS: Four gyroviruses, chicken anemia virus (CAV), human gyrovirus (HGV)/avian gyrovirus 2 (AGV2), gyrovirus 3 (GyV3) and a novel gyrovirus (tentatively designated as gyrovirus 4 (GyV4)) were identified in human stool specimens. GyV4, as well as CAV and AGV2/HGV were also detected in chicken skin and meat used for human consumption. CONCLUSIONS: A novel gyrovirus (GyV4) was identified in human stool and in chicken meat sold for human consumption. This virus was phylogenetically distinct from previously reported gyroviruses in chicken and humans (chicken anemia virus, human gyrovirus, avian gyrovirus 2 and recently reported gyrovirus 3). The epidemiology and pathogenesis of this virus in humans and in chicken needs to be further investigated.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcven_HK
dc.relation.ispartofJournal of Clinical Virologyen_HK
dc.subjectVirus DNAen_HK
dc.subjectChicken meaten_HK
dc.subjectDiarrheaen_HK
dc.subjectFeces analysisen_HK
dc.subjectGyrovirusen_HK
dc.titleCharacterization of a novel gyrovirus in human stool and chicken meaten_HK
dc.typeArticleen_HK
dc.identifier.emailChu, DKW: dkwchu@hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailChiu, SSS: ssschiu@hku.hken_HK
dc.identifier.emailNg, EM: emng@hku.hken_HK
dc.identifier.emailNg, IHY: ihyng@hkucc.hku.hk-
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityChiu, SSS=rp00421en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.jcv.2012.07.001en_HK
dc.identifier.pmid22824231-
dc.identifier.pmcidPMC3449218-
dc.identifier.scopuseid_2-s2.0-84866349607en_HK
dc.identifier.hkuros207973en_US
dc.identifier.hkuros209428-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84866349607&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume55en_HK
dc.identifier.issue3en_HK
dc.identifier.spage209en_HK
dc.identifier.epage213en_HK
dc.identifier.isiWOS:000309113000004-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridWang, D=55314657800en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridNg, IHY=8671050800en_HK
dc.identifier.scopusauthoridCheung, TK=16229531100en_HK
dc.identifier.scopusauthoridBauer, I=54580608800en_HK
dc.identifier.scopusauthoridNg, EM=54781662500en_HK
dc.identifier.scopusauthoridChan, KH=55315521600en_HK
dc.identifier.scopusauthoridChiu, SSS=7202291500en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridChu, DKW=7201734326en_HK
dc.identifier.citeulike11804352-

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