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Article: Characterization of a novel gyrovirus in human stool and chicken meat
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TitleCharacterization of a novel gyrovirus in human stool and chicken meat
 
AuthorsChu, DKW1
Poon, LLM1
Chiu, SSS1
Chan, KH1
Ng, EM1
Bauer, I2
Cheung, TK1
Ng, IHY1
Guan, Y1
Wang, D2
Peiris, JSM1
 
KeywordsVirus DNA
Chicken meat
Diarrhea
Feces analysis
Gyrovirus
 
Issue Date2012
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
 
CitationJournal of Clinical Virology, 2012, v. 55 n. 3, p. 209-213 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jcv.2012.07.001
 
AbstractBACKGROUND: Sequence-independent amplification of clinical specimens can lead to the identification of novel pathogens. OBJECTIVES: To identify novel viruses in human stool specimens from patients with diarrhea and to investigate the ecology and clinical significance of such viruses. STUDY DESIGN: Nucleic acid extracted from stool specimens from patients with diarrhea with no known etiology were subjected to random PCR amplification and Roche/454 pyrosequencing. Novel viruses identified were genetically and epidemiologically characterized. RESULTS: Four gyroviruses, chicken anemia virus (CAV), human gyrovirus (HGV)/avian gyrovirus 2 (AGV2), gyrovirus 3 (GyV3) and a novel gyrovirus (tentatively designated as gyrovirus 4 (GyV4)) were identified in human stool specimens. GyV4, as well as CAV and AGV2/HGV were also detected in chicken skin and meat used for human consumption. CONCLUSIONS: A novel gyrovirus (GyV4) was identified in human stool and in chicken meat sold for human consumption. This virus was phylogenetically distinct from previously reported gyroviruses in chicken and humans (chicken anemia virus, human gyrovirus, avian gyrovirus 2 and recently reported gyrovirus 3). The epidemiology and pathogenesis of this virus in humans and in chicken needs to be further investigated.
 
ISSN1386-6532
2012 Impact Factor: 3.287
2012 SCImago Journal Rankings: 1.294
 
DOIhttp://dx.doi.org/10.1016/j.jcv.2012.07.001
 
PubMed Central IDPMC3449218
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChu, DKW
 
dc.contributor.authorPoon, LLM
 
dc.contributor.authorChiu, SSS
 
dc.contributor.authorChan, KH
 
dc.contributor.authorNg, EM
 
dc.contributor.authorBauer, I
 
dc.contributor.authorCheung, TK
 
dc.contributor.authorNg, IHY
 
dc.contributor.authorGuan, Y
 
dc.contributor.authorWang, D
 
dc.contributor.authorPeiris, JSM
 
dc.date.accessioned2012-09-20T08:48:03Z
 
dc.date.available2012-09-20T08:48:03Z
 
dc.date.issued2012
 
dc.description.abstractBACKGROUND: Sequence-independent amplification of clinical specimens can lead to the identification of novel pathogens. OBJECTIVES: To identify novel viruses in human stool specimens from patients with diarrhea and to investigate the ecology and clinical significance of such viruses. STUDY DESIGN: Nucleic acid extracted from stool specimens from patients with diarrhea with no known etiology were subjected to random PCR amplification and Roche/454 pyrosequencing. Novel viruses identified were genetically and epidemiologically characterized. RESULTS: Four gyroviruses, chicken anemia virus (CAV), human gyrovirus (HGV)/avian gyrovirus 2 (AGV2), gyrovirus 3 (GyV3) and a novel gyrovirus (tentatively designated as gyrovirus 4 (GyV4)) were identified in human stool specimens. GyV4, as well as CAV and AGV2/HGV were also detected in chicken skin and meat used for human consumption. CONCLUSIONS: A novel gyrovirus (GyV4) was identified in human stool and in chicken meat sold for human consumption. This virus was phylogenetically distinct from previously reported gyroviruses in chicken and humans (chicken anemia virus, human gyrovirus, avian gyrovirus 2 and recently reported gyrovirus 3). The epidemiology and pathogenesis of this virus in humans and in chicken needs to be further investigated.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationJournal of Clinical Virology, 2012, v. 55 n. 3, p. 209-213 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jcv.2012.07.001
 
dc.identifier.citeulike11804352
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jcv.2012.07.001
 
dc.identifier.epage213
 
dc.identifier.hkuros207973
 
dc.identifier.hkuros209428
 
dc.identifier.issn1386-6532
2012 Impact Factor: 3.287
2012 SCImago Journal Rankings: 1.294
 
dc.identifier.issue3
 
dc.identifier.pmcidPMC3449218
 
dc.identifier.pmid22824231
 
dc.identifier.scopuseid_2-s2.0-84866349607
 
dc.identifier.spage209
 
dc.identifier.urihttp://hdl.handle.net/10722/166779
 
dc.identifier.volume55
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofJournal of Clinical Virology
 
dc.relation.referencesReferences in Scopus
 
dc.subjectVirus DNA
 
dc.subjectChicken meat
 
dc.subjectDiarrhea
 
dc.subjectFeces analysis
 
dc.subjectGyrovirus
 
dc.titleCharacterization of a novel gyrovirus in human stool and chicken meat
 
dc.typeArticle
 
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<contributor.author>Bauer, I</contributor.author>
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<contributor.author>Guan, Y</contributor.author>
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<description.abstract>BACKGROUND: Sequence-independent amplification of clinical specimens can lead to the identification of novel pathogens. OBJECTIVES: To identify novel viruses in human stool specimens from patients with diarrhea and to investigate the ecology and clinical significance of such viruses. STUDY DESIGN: Nucleic acid extracted from stool specimens from patients with diarrhea with no known etiology were subjected to random PCR amplification and Roche/454 pyrosequencing. Novel viruses identified were genetically and epidemiologically characterized. RESULTS: Four gyroviruses, chicken anemia virus (CAV), human gyrovirus (HGV)/avian gyrovirus 2 (AGV2), gyrovirus 3 (GyV3) and a novel gyrovirus (tentatively designated as gyrovirus 4 (GyV4)) were identified in human stool specimens. GyV4, as well as CAV and AGV2/HGV were also detected in chicken skin and meat used for human consumption. CONCLUSIONS: A novel gyrovirus (GyV4) was identified in human stool and in chicken meat sold for human consumption. This virus was phylogenetically distinct from previously reported gyroviruses in chicken and humans (chicken anemia virus, human gyrovirus, avian gyrovirus 2 and recently reported gyrovirus 3). The epidemiology and pathogenesis of this virus in humans and in chicken needs to be further investigated.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Washington University in St. Louis School of Medicine