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Article: The blood-biliary barrier, tight junctions and human liver diseases

TitleThe blood-biliary barrier, tight junctions and human liver diseases
Authors
Issue Date2012
PublisherLandes Bioscience & Springer New York LLC.
Citation
Advances in experimental medicine and biology, 2012, v. 763, p. 171-185 How to Cite?
AbstractTight junction (TJ) composes of an intriguing class of cell junction molecules, for which these molecules share similar organizations and structure features among different organs. Fourtypes of transmembrane molecules namely occludins, claudins, junctional adhesion molecules and coxsackievirus and adenovirus receptors act as core units and each link directly and indirectly with a panel of peripheral molecules and underlying cytoskeletons to constitute the functional protein complexes at TJs. Individual TJ complex alone or in co-operation with other complexes via cross-talk mediated by peripheral molecules activate signaling pathways pertinent to various physiological and pathological processes in livers. In human livers, TJs are located at two regions in association with hepatocytes and cholangiocytes and perform major roles in controlling bile flow and metabolism. Apart from this physiological function, the other functions of TJs relating to liver diseases of hepatitis and liver cancer are gradually uncovered. The understanding of how TJs are involved in these clinical conditions hint for the development of new treatments at the molecular level.
Persistent Identifierhttp://hdl.handle.net/10722/166597
ISSN
2015 Impact Factor: 1.953
2015 SCImago Journal Rankings: 0.887

 

DC FieldValueLanguage
dc.contributor.authorLee, NPYen_US
dc.date.accessioned2012-09-20T08:41:56Z-
dc.date.available2012-09-20T08:41:56Z-
dc.date.issued2012en_US
dc.identifier.citationAdvances in experimental medicine and biology, 2012, v. 763, p. 171-185en_US
dc.identifier.issn0065-2598-
dc.identifier.urihttp://hdl.handle.net/10722/166597-
dc.description.abstractTight junction (TJ) composes of an intriguing class of cell junction molecules, for which these molecules share similar organizations and structure features among different organs. Fourtypes of transmembrane molecules namely occludins, claudins, junctional adhesion molecules and coxsackievirus and adenovirus receptors act as core units and each link directly and indirectly with a panel of peripheral molecules and underlying cytoskeletons to constitute the functional protein complexes at TJs. Individual TJ complex alone or in co-operation with other complexes via cross-talk mediated by peripheral molecules activate signaling pathways pertinent to various physiological and pathological processes in livers. In human livers, TJs are located at two regions in association with hepatocytes and cholangiocytes and perform major roles in controlling bile flow and metabolism. Apart from this physiological function, the other functions of TJs relating to liver diseases of hepatitis and liver cancer are gradually uncovered. The understanding of how TJs are involved in these clinical conditions hint for the development of new treatments at the molecular level.-
dc.languageengen_US
dc.publisherLandes Bioscience & Springer New York LLC.en_US
dc.relation.ispartofAdvances in experimental medicine and biologyen_US
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshLiver - blood supply - metabolism - pathology-
dc.subject.meshLiver Diseases - metabolism - pathology-
dc.subject.meshLiver Neoplasms - genetics - metabolism - pathology-
dc.subject.meshTight Junctions - genetics - metabolism - pathology-
dc.titleThe blood-biliary barrier, tight junctions and human liver diseasesen_US
dc.typeArticleen_US
dc.identifier.emailLee, NPY: nikkilee@hku.hken_US
dc.identifier.authorityLee, NPY=rp00263en_US
dc.identifier.doi10.1007/978-1-4614-4711-5_8-
dc.identifier.pmid23397624-
dc.identifier.scopuseid_2-s2.0-84875780246-
dc.identifier.hkuros211309en_US
dc.identifier.hkuros228555-
dc.identifier.volume763en_US
dc.identifier.spage171en_US
dc.identifier.epage185en_US
dc.publisher.placeUnited States-

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