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Conference Paper: Inhibitory activities of vitamins on 7-ketocholesterol formation in both chemical model systems and beef patties

TitleInhibitory activities of vitamins on 7-ketocholesterol formation in both chemical model systems and beef patties
Authors
Issue Date2012
PublisherAmerican Chemical Society (ACS).
Citation
The 13th International Flavor Conference cum 5th George Charalambous Memorial Symposium, Porto Heli, Greece, 29 May-1 June 2012. In Conference Program, 2012, p. 26, abstract O-V-04 How to Cite?
AbstractCholesterol Oxidation Products (COPs), produced by Cholesterol oxidation, are a family of oxidative products generated in high-temperature processing and prolonged storage. COPs could be differentiated into two distinct origins – enzymatic and non-enzymatic source. They are implicated in various food sources, and known to exert certain chemical effects like toxicity, HMG-COA reductase inhibition and atherogenesis effect on human. Considerable researches were conducted to develop strategies as to reduce the associated risk. Yet, direct evidence regarding their effects on COPs formation is still lacking. The formation pathways of COPs have partially elucidated. However, there is still controversy over the inhibition mechanism on COPs formation. The objective of the present study is to identify potent inhibitors of COPs formation from 15 vitamins using chromatographic methods in beef patties. Moreover, the roles of pyridoxamine (the most potent inhibitors) in the formation of 7-ketocholesterol is characterized. The detailed mechanism involved in cholesterol oxidation model system is elucidated. To conclude, vitamin C, A, E and PM can significantly lower the formation of 7-ketocholesterol. Their antioxidant activities only make minor contribution to their inhibitory activities. Their inhibitory activities are mainly mediated via their direct participation in Cholesterol oxidation: direct trapping of the final secondary oxidative product – 7-ketocholesterol.
DescriptionTechnical Session V: abstract O-V-04
Persistent Identifierhttp://hdl.handle.net/10722/166228

 

DC FieldValueLanguage
dc.contributor.authorWong, Den_US
dc.contributor.authorCheng, KWen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-09-20T08:30:32Z-
dc.date.available2012-09-20T08:30:32Z-
dc.date.issued2012en_US
dc.identifier.citationThe 13th International Flavor Conference cum 5th George Charalambous Memorial Symposium, Porto Heli, Greece, 29 May-1 June 2012. In Conference Program, 2012, p. 26, abstract O-V-04en_US
dc.identifier.urihttp://hdl.handle.net/10722/166228-
dc.descriptionTechnical Session V: abstract O-V-04-
dc.description.abstractCholesterol Oxidation Products (COPs), produced by Cholesterol oxidation, are a family of oxidative products generated in high-temperature processing and prolonged storage. COPs could be differentiated into two distinct origins – enzymatic and non-enzymatic source. They are implicated in various food sources, and known to exert certain chemical effects like toxicity, HMG-COA reductase inhibition and atherogenesis effect on human. Considerable researches were conducted to develop strategies as to reduce the associated risk. Yet, direct evidence regarding their effects on COPs formation is still lacking. The formation pathways of COPs have partially elucidated. However, there is still controversy over the inhibition mechanism on COPs formation. The objective of the present study is to identify potent inhibitors of COPs formation from 15 vitamins using chromatographic methods in beef patties. Moreover, the roles of pyridoxamine (the most potent inhibitors) in the formation of 7-ketocholesterol is characterized. The detailed mechanism involved in cholesterol oxidation model system is elucidated. To conclude, vitamin C, A, E and PM can significantly lower the formation of 7-ketocholesterol. Their antioxidant activities only make minor contribution to their inhibitory activities. Their inhibitory activities are mainly mediated via their direct participation in Cholesterol oxidation: direct trapping of the final secondary oxidative product – 7-ketocholesterol.-
dc.languageengen_US
dc.publisherAmerican Chemical Society (ACS).-
dc.relation.ispartof13th International Flavor Conference Program-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleInhibitory activities of vitamins on 7-ketocholesterol formation in both chemical model systems and beef pattiesen_US
dc.typeConference_Paperen_US
dc.identifier.emailWang, M: mfwang@hku.hken_US
dc.identifier.authorityWang, M=rp00800en_US
dc.description.naturepostprint-
dc.identifier.hkuros206354en_US
dc.identifier.spage26en_US
dc.identifier.epage26en_US
dc.publisher.placeUnited States-

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