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Article: Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats

TitleEffects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats
Authors
KeywordsBDNF
Corticosterone
Hippocampal cell proliferation
IGF-1
Stress
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
Citation
Neuroscience, 2012, v. 222, p. 289-301 How to Cite?
AbstractPrevious studies have shown that a 2-week treatment with 40mg/kg corticosterone (CORT) in rats suppresses hippocampal neurogenesis and decreases hippocampal brain-derived neurotrophic factor (BDNF) levels and impairs spatial learning, all of which could be counteracted by voluntary wheel running. BDNF and insulin-like growth factor (IGF-1) have been suggested to mediate physical exercise-enhanced hippocampal neurogenesis and cognition. Here we examined whether such running-elicited benefits were accompanied by corresponding changes of peripheral BDNF and IGF-1 levels in a rat model of stress. We examined the effects of acute (5days) and chronic (4weeks) treatment with CORT and/or wheel running on (1) hippocampal cell proliferation, (2) spatial learning and memory and (3) plasma levels of BDNF and IGF-1. Acute CORT treatment improved spatial learning without altered cell proliferation compared to vehicle treatment. Acute CORT-treated non-runners showed an increased trend in plasma BDNF levels together with a significant increase in hippocampal BDNF levels. Acute running showed no effect on cognition, cell proliferation and peripheral BDNF and IGF-1 levels. Conversely, chronic CORT treatment in non-runners significantly impaired spatial learning and suppressed cell proliferation in association with a decreased trend in plasma BDNF level and a significant increase in hippocampal BDNF levels. Running counteracted cognitive deficit and restored hippocampal cell proliferation following chronic CORT treatment; but without corresponding changes in plasma BDNF and IGF-1 levels. The results suggest that the beneficial effects of acute stress on cognitive improvement may be mediated by BDNF-enhanced synaptic plasticity that is hippocampal cell proliferation-independent, whereas chronic stress may impair cognition by decreasing hippocampal cell proliferation and BDNF levels. Furthermore, the results indicate a trend in changes of plasma BDNF levels associated with a significant alteration in hippocampal levels, suggesting that treatment with running/CORT for 4 weeks may induce a change in central levels of hippocampal BDNF level, which may not lead to a significant change in peripheral levels.
Persistent Identifierhttp://hdl.handle.net/10722/166066
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.768
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYau, SYen_US
dc.contributor.authorLau, BWMen_US
dc.contributor.authorZhang, EDen_US
dc.contributor.authorLee, JCDen_US
dc.contributor.authorLi, Aen_US
dc.contributor.authorLee, TMCen_US
dc.contributor.authorChing, YPen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorSo, KFen_US
dc.date.accessioned2012-09-20T08:27:14Z-
dc.date.available2012-09-20T08:27:14Z-
dc.date.issued2012en_US
dc.identifier.citationNeuroscience, 2012, v. 222, p. 289-301en_US
dc.identifier.issn0306-4522-
dc.identifier.urihttp://hdl.handle.net/10722/166066-
dc.description.abstractPrevious studies have shown that a 2-week treatment with 40mg/kg corticosterone (CORT) in rats suppresses hippocampal neurogenesis and decreases hippocampal brain-derived neurotrophic factor (BDNF) levels and impairs spatial learning, all of which could be counteracted by voluntary wheel running. BDNF and insulin-like growth factor (IGF-1) have been suggested to mediate physical exercise-enhanced hippocampal neurogenesis and cognition. Here we examined whether such running-elicited benefits were accompanied by corresponding changes of peripheral BDNF and IGF-1 levels in a rat model of stress. We examined the effects of acute (5days) and chronic (4weeks) treatment with CORT and/or wheel running on (1) hippocampal cell proliferation, (2) spatial learning and memory and (3) plasma levels of BDNF and IGF-1. Acute CORT treatment improved spatial learning without altered cell proliferation compared to vehicle treatment. Acute CORT-treated non-runners showed an increased trend in plasma BDNF levels together with a significant increase in hippocampal BDNF levels. Acute running showed no effect on cognition, cell proliferation and peripheral BDNF and IGF-1 levels. Conversely, chronic CORT treatment in non-runners significantly impaired spatial learning and suppressed cell proliferation in association with a decreased trend in plasma BDNF level and a significant increase in hippocampal BDNF levels. Running counteracted cognitive deficit and restored hippocampal cell proliferation following chronic CORT treatment; but without corresponding changes in plasma BDNF and IGF-1 levels. The results suggest that the beneficial effects of acute stress on cognitive improvement may be mediated by BDNF-enhanced synaptic plasticity that is hippocampal cell proliferation-independent, whereas chronic stress may impair cognition by decreasing hippocampal cell proliferation and BDNF levels. Furthermore, the results indicate a trend in changes of plasma BDNF levels associated with a significant alteration in hippocampal levels, suggesting that treatment with running/CORT for 4 weeks may induce a change in central levels of hippocampal BDNF level, which may not lead to a significant change in peripheral levels.-
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscienceen_US
dc.relation.ispartofNeuroscienceen_US
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Neuroscience. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuroscience, 2012, v. 222, p. 289-301. DOI: 10.1016/j.neuroscience.2012.07.019-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBDNF-
dc.subjectCorticosterone-
dc.subjectHippocampal cell proliferation-
dc.subjectIGF-1-
dc.subjectStress-
dc.titleEffects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed ratsen_US
dc.typeArticleen_US
dc.identifier.emailYau, SY: yausukyu@hku.hken_US
dc.identifier.emailLau, BWM: bwmlau@hku.hken_US
dc.identifier.emailZhang, ED: endongz@hkusua.hku.hken_US
dc.identifier.emailLee, TMC: tmclee@hku.hken_US
dc.identifier.emailChing, YP: ypching@hku.hken_US
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_US
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_US
dc.identifier.authorityChing, YP=rp00469en_US
dc.identifier.authorityLee, TMC=rp00564en_US
dc.identifier.authorityXu, A=rp00485en_US
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.neuroscience.2012.07.019-
dc.identifier.pmid22813995-
dc.identifier.scopuseid_2-s2.0-84865616488-
dc.identifier.hkuros206524en_US
dc.identifier.volume222en_US
dc.identifier.spage289-
dc.identifier.epage301-
dc.identifier.isiWOS:000309085500026-
dc.publisher.placeNetherlands-
dc.identifier.citeulike11200913-

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