Article: Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish
| Title | Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish |
|---|---|
| Authors | Yu, L3 Lam, JCW2 Guo, Y3 Wu, RSS1 Lam, PKS2 Zhou, B3 |
| Issue Date | 2011 |
| Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/est |
| Citation | Environmental Science And Technology, 2011, v. 45 n. 24, p. 10652-10659 [How to Cite?] DOI: http://dx.doi.org/10.1021/es2026592 |
| Abstract | Polybrominated diphenyl ethers (PBDEs) have the potential to disrupt the thyroid endocrine system. The objective of the present study was to characterize the disrupting effects of long-term exposure on the thyroid endocrine system in adult fish and their progeny following parental exposure to PBDEs. Zebrafish (Danio rerio) embryos were exposed to environmentally relevant concentrations (1, 3, and 10 μg/L) of the PBDE mixture DE-71 for 5 months until sexual maturation. In the F0 generation, exposure to DE-71 significantly increased plasma thyroxine (T4) but not 3,5,3′-triiodothyronine (T3) in females. This increased T4 was accompanied by decreased mRNA levels of corticotropin-releasing hormone (CRH) and thyrotropin β-subunit (TSHβ) in the brain. The F1 generation was further examined with or without continued DE-71 treatment conditions. Exposure to DE-71 in the F0 fish caused significant increases in T4 and T3 levels in the F1 larvae and modified gene expressions in the hypothalamic-pituitary-thyroid axis (HPT axis) under both conditions. Decreased hatching and inhibition of growth in the F1 offspring were observed in the condition without DE-71 treatment. Continued DE-71 treatment in the F1 embryos/larvae resulted in further decreased hatching, and increased malformation rates compared with those without DE-71 exposure. Analysis of F1 eggs indicated that parental exposure to DE-71 could result in a transfer of PBDEs and thyroid hormones (THs) to their offspring. For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations. © 2011 American Chemical Society. |
| ISSN | 0013-936X 2011 Impact Factor: 5.228 2011 SCImago Journal Rankings: 0.305 |
| DOI | http://dx.doi.org/10.1021/es2026592 |
| References | References in Scopus |
| dc.contributor.author | Yu, L |
|---|---|
| dc.contributor.author | Lam, JCW |
| dc.contributor.author | Guo, Y |
| dc.contributor.author | Wu, RSS |
| dc.contributor.author | Lam, PKS |
| dc.contributor.author | Zhou, B |
| dc.date.accessioned | 2012-09-20T08:25:45Z |
| dc.date.available | 2012-09-20T08:25:45Z |
| dc.date.issued | 2011 |
| dc.description.abstract | Polybrominated diphenyl ethers (PBDEs) have the potential to disrupt the thyroid endocrine system. The objective of the present study was to characterize the disrupting effects of long-term exposure on the thyroid endocrine system in adult fish and their progeny following parental exposure to PBDEs. Zebrafish (Danio rerio) embryos were exposed to environmentally relevant concentrations (1, 3, and 10 μg/L) of the PBDE mixture DE-71 for 5 months until sexual maturation. In the F0 generation, exposure to DE-71 significantly increased plasma thyroxine (T4) but not 3,5,3′-triiodothyronine (T3) in females. This increased T4 was accompanied by decreased mRNA levels of corticotropin-releasing hormone (CRH) and thyrotropin β-subunit (TSHβ) in the brain. The F1 generation was further examined with or without continued DE-71 treatment conditions. Exposure to DE-71 in the F0 fish caused significant increases in T4 and T3 levels in the F1 larvae and modified gene expressions in the hypothalamic-pituitary-thyroid axis (HPT axis) under both conditions. Decreased hatching and inhibition of growth in the F1 offspring were observed in the condition without DE-71 treatment. Continued DE-71 treatment in the F1 embryos/larvae resulted in further decreased hatching, and increased malformation rates compared with those without DE-71 exposure. Analysis of F1 eggs indicated that parental exposure to DE-71 could result in a transfer of PBDEs and thyroid hormones (THs) to their offspring. For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations. © 2011 American Chemical Society. |
| dc.description.nature | Link_to_subscribed_fulltext |
| dc.identifier.citation | Environmental Science And Technology, 2011, v. 45 n. 24, p. 10652-10659 [How to Cite?] DOI: http://dx.doi.org/10.1021/es2026592 |
| dc.identifier.doi | http://dx.doi.org/10.1021/es2026592 |
| dc.identifier.epage | 10659 |
| dc.identifier.hkuros | 208936 |
| dc.identifier.hkuros | 203339 |
| dc.identifier.issn | 0013-936X 2011 Impact Factor: 5.228 2011 SCImago Journal Rankings: 0.305 |
| dc.identifier.issue | 24 |
| dc.identifier.pmid | 22039834 |
| dc.identifier.scopus | eid_2-s2.0-83455187174 |
| dc.identifier.spage | 10652 |
| dc.identifier.uri | http://hdl.handle.net/10722/165949 |
| dc.identifier.volume | 45 |
| dc.language | eng |
| dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/est |
| dc.publisher.place | United States |
| dc.relation.ispartof | Environmental Science and Technology |
| dc.relation.references | References in Scopus |
| dc.title | Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish |
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- City University of Hong Kong
- Institute of Hydrobiology, Chinese Academy of Sciences