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Article: Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish

TitleParental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish
Authors
Issue Date2011
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/est
Citation
Environmental Science And Technology, 2011, v. 45 n. 24, p. 10652-10659 How to Cite?
AbstractPolybrominated diphenyl ethers (PBDEs) have the potential to disrupt the thyroid endocrine system. The objective of the present study was to characterize the disrupting effects of long-term exposure on the thyroid endocrine system in adult fish and their progeny following parental exposure to PBDEs. Zebrafish (Danio rerio) embryos were exposed to environmentally relevant concentrations (1, 3, and 10 μg/L) of the PBDE mixture DE-71 for 5 months until sexual maturation. In the F0 generation, exposure to DE-71 significantly increased plasma thyroxine (T4) but not 3,5,3′-triiodothyronine (T3) in females. This increased T4 was accompanied by decreased mRNA levels of corticotropin-releasing hormone (CRH) and thyrotropin β-subunit (TSHβ) in the brain. The F1 generation was further examined with or without continued DE-71 treatment conditions. Exposure to DE-71 in the F0 fish caused significant increases in T4 and T3 levels in the F1 larvae and modified gene expressions in the hypothalamic-pituitary-thyroid axis (HPT axis) under both conditions. Decreased hatching and inhibition of growth in the F1 offspring were observed in the condition without DE-71 treatment. Continued DE-71 treatment in the F1 embryos/larvae resulted in further decreased hatching, and increased malformation rates compared with those without DE-71 exposure. Analysis of F1 eggs indicated that parental exposure to DE-71 could result in a transfer of PBDEs and thyroid hormones (THs) to their offspring. For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations. © 2011 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/165949
ISSN
2014 Impact Factor: 5.330
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, Len_HK
dc.contributor.authorLam, JCWen_HK
dc.contributor.authorGuo, Yen_HK
dc.contributor.authorWu, RSSen_HK
dc.contributor.authorLam, PKSen_HK
dc.contributor.authorZhou, Ben_HK
dc.date.accessioned2012-09-20T08:25:45Z-
dc.date.available2012-09-20T08:25:45Z-
dc.date.issued2011en_HK
dc.identifier.citationEnvironmental Science And Technology, 2011, v. 45 n. 24, p. 10652-10659en_HK
dc.identifier.issn0013-936Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/165949-
dc.description.abstractPolybrominated diphenyl ethers (PBDEs) have the potential to disrupt the thyroid endocrine system. The objective of the present study was to characterize the disrupting effects of long-term exposure on the thyroid endocrine system in adult fish and their progeny following parental exposure to PBDEs. Zebrafish (Danio rerio) embryos were exposed to environmentally relevant concentrations (1, 3, and 10 μg/L) of the PBDE mixture DE-71 for 5 months until sexual maturation. In the F0 generation, exposure to DE-71 significantly increased plasma thyroxine (T4) but not 3,5,3′-triiodothyronine (T3) in females. This increased T4 was accompanied by decreased mRNA levels of corticotropin-releasing hormone (CRH) and thyrotropin β-subunit (TSHβ) in the brain. The F1 generation was further examined with or without continued DE-71 treatment conditions. Exposure to DE-71 in the F0 fish caused significant increases in T4 and T3 levels in the F1 larvae and modified gene expressions in the hypothalamic-pituitary-thyroid axis (HPT axis) under both conditions. Decreased hatching and inhibition of growth in the F1 offspring were observed in the condition without DE-71 treatment. Continued DE-71 treatment in the F1 embryos/larvae resulted in further decreased hatching, and increased malformation rates compared with those without DE-71 exposure. Analysis of F1 eggs indicated that parental exposure to DE-71 could result in a transfer of PBDEs and thyroid hormones (THs) to their offspring. For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations. © 2011 American Chemical Society.en_HK
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/esten_HK
dc.relation.ispartofEnvironmental Science and Technologyen_HK
dc.titleParental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafishen_HK
dc.typeArticleen_HK
dc.identifier.emailWu, RSS: rudolfwu@hku.hken_HK
dc.identifier.authorityWu, RSS=rp01398en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/es2026592en_HK
dc.identifier.pmid22039834-
dc.identifier.scopuseid_2-s2.0-83455187174en_HK
dc.identifier.hkuros208936en_US
dc.identifier.hkuros203339-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83455187174&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue24en_HK
dc.identifier.spage10652en_HK
dc.identifier.epage10659en_HK
dc.identifier.isiWOS:000298118300054-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYu, L=37022805800en_HK
dc.identifier.scopusauthoridLam, JCW=24178129400en_HK
dc.identifier.scopusauthoridGuo, Y=35798216000en_HK
dc.identifier.scopusauthoridWu, RSS=7402945079en_HK
dc.identifier.scopusauthoridLam, PKS=7202365776en_HK
dc.identifier.scopusauthoridZhou, B=7401906781en_HK

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