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Conference Paper: CDK5-mediated phosphorylation of SIRT1 at serine 47 contributes to the development of endothelial senescence

TitleCDK5-mediated phosphorylation of SIRT1 at serine 47 contributes to the development of endothelial senescence
Authors
Issue Date2012
PublisherInternational Symposium on Atherosclerosis.
Citation
The 16th International Symposium on Atherosclerosis (ISA 2012), Sydney, Australia, 25-29 March 2012. How to Cite?
AbstractBACKGROUND: Senescence of endothelial cells precedes the occurrence of vascular dysfunction and promotes the development of atherosclerosis. SIRT1 is a NAD-dependent deacetylase possessing anti-aging activities. In senescent endothelial cells, both the activity and expression level of SIRT1 are decreased. However, mechanisms underlying this down-regulation of SIRT1 are largely uncharacterized. The present study evaluated the regulation and role of ...
DescriptionISA 2012 Monday Abstracts
Poster Session 1 – Vascular Biology of Atherosclerosis: Poster no. 98: Monday abstract no. 206
Persistent Identifierhttp://hdl.handle.net/10722/165626

 

DC FieldValueLanguage
dc.contributor.authorBai, Ben_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorWang, Yen_US
dc.date.accessioned2012-09-20T08:21:21Z-
dc.date.available2012-09-20T08:21:21Z-
dc.date.issued2012en_US
dc.identifier.citationThe 16th International Symposium on Atherosclerosis (ISA 2012), Sydney, Australia, 25-29 March 2012.en_US
dc.identifier.urihttp://hdl.handle.net/10722/165626-
dc.descriptionISA 2012 Monday Abstracts-
dc.descriptionPoster Session 1 – Vascular Biology of Atherosclerosis: Poster no. 98: Monday abstract no. 206-
dc.description.abstractBACKGROUND: Senescence of endothelial cells precedes the occurrence of vascular dysfunction and promotes the development of atherosclerosis. SIRT1 is a NAD-dependent deacetylase possessing anti-aging activities. In senescent endothelial cells, both the activity and expression level of SIRT1 are decreased. However, mechanisms underlying this down-regulation of SIRT1 are largely uncharacterized. The present study evaluated the regulation and role of ...-
dc.languageengen_US
dc.publisherInternational Symposium on Atherosclerosis.-
dc.relation.ispartofInternational Symposium on Atherosclerosis, ISA 2012en_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleCDK5-mediated phosphorylation of SIRT1 at serine 47 contributes to the development of endothelial senescenceen_US
dc.typeConference_Paperen_US
dc.identifier.emailBai, B: caveolim@hku.hken_US
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_US
dc.identifier.emailWang, Y: yuwanghk@hku.hk-
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.identifier.authorityWang, Y=rp00239en_US
dc.description.naturepostprint-
dc.identifier.hkuros210639en_US
dc.identifier.volumeMonday Abstracts-
dc.publisher.placeAustralia-
dc.description.otherThe 16th International Symposium on Atherosclerosis (ISA2012), Sydney, Australia, 25-29 March 2012. In ISA2012 Monday Abstracts-

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