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Conference Paper: Neonatal perturbation of vestibular GABAergic transmission alters spatial navigation behaviors in a rat model of dead reckoning

TitleNeonatal perturbation of vestibular GABAergic transmission alters spatial navigation behaviors in a rat model of dead reckoning
Authors
Issue Date2012
PublisherHKSN & BPHK.
Citation
The Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, Hong Kong, 14-15 June 2012. In Program Book of the Joint Scientific Meeting, 2012, p. 68-69, abstract P49 How to Cite?
AbstractRodents navigate their surroundings using cues derived from the environment and from self-movement. To assess the role of vestibular information in providing idiothetic cues for spatial navigation, dead reckoning which requires the integration of cues on direction and distance for path-finding tasks was studied. We have reported previously that changes in GABAergic synaptic efficacy could be elicited in the vestubular nucleus during a limited time window of postnatal development. To study the role of GABAergic transmission in the developing vestibular nucleus on the acquisition of spatial recognition, we implanted above the vestibular nucleus of postnatal day 1 (P1) rats with a slice of Elvax loaded with GABAA receptor agonist (muscimol) or GABAA receptor antagonist (bicuculline). These animals were allowed to recover and were tested for dead reckoning at adult stage. When compared with the sham control group, rats treated with muscimol at P1 had a shortening of both the training days and searching time in light probe, dark probe and new location probe. On the other hand, treatment of bicuculline at P1 significantly prolonged the searching time in dark probe and new location probe. Besides, treatment of either muscimol or bicuculline had no evident effect on homeward time. Taken together, our data suggest that neonatal perturbation of GABAergic transmission in the vestibular nucleus impacted on the expression of vestibular-related spatial navigation behaviors.
DescriptionPoster Presentation: P49
Persistent Identifierhttp://hdl.handle.net/10722/165583

 

DC FieldValueLanguage
dc.contributor.authorChen, Wen_US
dc.contributor.authorMa, CWen_US
dc.contributor.authorLai, CHen_US
dc.contributor.authorChan, YSen_US
dc.date.accessioned2012-09-20T08:20:14Z-
dc.date.available2012-09-20T08:20:14Z-
dc.date.issued2012en_US
dc.identifier.citationThe Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, Hong Kong, 14-15 June 2012. In Program Book of the Joint Scientific Meeting, 2012, p. 68-69, abstract P49en_US
dc.identifier.urihttp://hdl.handle.net/10722/165583-
dc.descriptionPoster Presentation: P49-
dc.description.abstractRodents navigate their surroundings using cues derived from the environment and from self-movement. To assess the role of vestibular information in providing idiothetic cues for spatial navigation, dead reckoning which requires the integration of cues on direction and distance for path-finding tasks was studied. We have reported previously that changes in GABAergic synaptic efficacy could be elicited in the vestubular nucleus during a limited time window of postnatal development. To study the role of GABAergic transmission in the developing vestibular nucleus on the acquisition of spatial recognition, we implanted above the vestibular nucleus of postnatal day 1 (P1) rats with a slice of Elvax loaded with GABAA receptor agonist (muscimol) or GABAA receptor antagonist (bicuculline). These animals were allowed to recover and were tested for dead reckoning at adult stage. When compared with the sham control group, rats treated with muscimol at P1 had a shortening of both the training days and searching time in light probe, dark probe and new location probe. On the other hand, treatment of bicuculline at P1 significantly prolonged the searching time in dark probe and new location probe. Besides, treatment of either muscimol or bicuculline had no evident effect on homeward time. Taken together, our data suggest that neonatal perturbation of GABAergic transmission in the vestibular nucleus impacted on the expression of vestibular-related spatial navigation behaviors.-
dc.languageengen_US
dc.publisherHKSN & BPHK.-
dc.relation.ispartofProgram Book of the Joint Scientific Meetingen_US
dc.titleNeonatal perturbation of vestibular GABAergic transmission alters spatial navigation behaviors in a rat model of dead reckoningen_US
dc.typeConference_Paperen_US
dc.identifier.emailChen, W: chenwq@hku.hken_US
dc.identifier.emailMa, CW: cwma2010@hku.hken_US
dc.identifier.emailLai, CH: chlaib@hku.hken_US
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.authorityLai, CH=rp00396en_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros200063en_US
dc.identifier.hkuros209400-
dc.identifier.spage68-
dc.identifier.epage69-
dc.publisher.placeHong Kong-

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