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Conference Paper: The role of the intervertebral disc niche on embryonic stem cell differentiation and intervertebral disc regeneration

TitleThe role of the intervertebral disc niche on embryonic stem cell differentiation and intervertebral disc regeneration
Authors
Issue Date2011
Citation
The 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011. How to Cite?
AbstractThe intervertebral disc (IVD) is a highly specialised environment, where cell, water and proteoglycan decrease is strongly associated with disc degeneration, which can lead to back pain. We postulate that the IVD niche is a major factor for IVD cell development and maintenance, and can play a role in progenitor differentiation to become disc cells. The understanding of how stem/progenitor cells develop into IVD cells could potentially facilitate the development of regenerative therapies for degenerated IVD. Here, we aim to introduce human embryonic stem cells (ESCs) into the IVD environment using a model of decellularised bovine disc, and examine how the IVD niche impacts on phenotypic changes in vitro using …
DescriptionDMM 2011 entitled: Re-engineering Regenerative Medicine
Poster Session - Orthopedic Regeneration: no. 91
Persistent Identifierhttp://hdl.handle.net/10722/165552

 

DC FieldValueLanguage
dc.contributor.authorTam, Ven_US
dc.contributor.authorLeung, Ven_US
dc.contributor.authorCheung, Ken_US
dc.date.accessioned2012-09-20T08:19:30Z-
dc.date.available2012-09-20T08:19:30Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/165552-
dc.descriptionDMM 2011 entitled: Re-engineering Regenerative Medicine-
dc.descriptionPoster Session - Orthopedic Regeneration: no. 91-
dc.description.abstractThe intervertebral disc (IVD) is a highly specialised environment, where cell, water and proteoglycan decrease is strongly associated with disc degeneration, which can lead to back pain. We postulate that the IVD niche is a major factor for IVD cell development and maintenance, and can play a role in progenitor differentiation to become disc cells. The understanding of how stem/progenitor cells develop into IVD cells could potentially facilitate the development of regenerative therapies for degenerated IVD. Here, we aim to introduce human embryonic stem cells (ESCs) into the IVD environment using a model of decellularised bovine disc, and examine how the IVD niche impacts on phenotypic changes in vitro using …-
dc.languageengen_US
dc.relation.ispartofDay of Molecular Medicine, DMM 2011en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleThe role of the intervertebral disc niche on embryonic stem cell differentiation and intervertebral disc regenerationen_US
dc.typeConference_Paperen_US
dc.identifier.emailTam, V: vivtam@hku.hken_US
dc.identifier.emailLeung, V: vicleung@hku.hken_US
dc.identifier.emailCheung, K: cheungmc@hku.hken_US
dc.identifier.authorityLeung, V=rp01764en_US
dc.description.naturepostprint-
dc.identifier.hkuros210237en_US

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