File Download
Supplementary

Conference Paper: A novel biodegradable injectable polycaprolactone-magnesium hybrid for orthopaedic implantation

TitleA novel biodegradable injectable polycaprolactone-magnesium hybrid for orthopaedic implantation
Authors
Issue Date2011
PublisherInternational Society of Orthopaedic Surgery and Traumatology
Citation
The 25th Triennial World Congress (SICOT 2011), Prague, Czech Republic, 6-9 September 2011. In Abstract Book of 25th Triennial World Congress, SICOT 2011, p. abstract no. 29670 How to Cite?
AbstractCurrently developed injectable materials such as calcium-based bone cements have tried to replace the conventional PMMA. However, their brittleness affects their stability and may cause another fracture. Hence, our group has recently fabricated an injectable biodegradable polycaprolactone (PCL) - magnesium (Mg) hybrids to solve the problems. A wide range of mechanical properties was obtained by altering the PCL and Mg composition. And the rapid degradation of Mg was suppressed by the silane coupling agent surface treatment. This study aims to investigate the mechanical and in-vitro properties of the newly developed hybrid. Four types of PCL-Mg hybrids were prepared by incorporating 0.1g and 0.6g Mg beads with and without silane treatment into 1g PCL, respectively. Compression test was conducted to evaluate the mechanical properties of the hybrids. Green fluorescent protein osteoblasts (GFPOB) were cultured on the hybrids for 1 and 3 day(s) to evaluate their cell attachment and proliferation. 1-fold and 3-fold higher compressive moduli were found on the 0.1g and 0.6g Mg-PCL hybrids with and without silane treatment than pure PCL, respectively, indicating that the mechanical property of pure PCL was enhanced by incorporating Mg beads. GFPOBs grew well on the hybrids except the untreated 0.6g Mg-PCL. This was probably due to the large release of Mg which may cause toxic effect. Hence, the results suggested that the silane treatment was able to slow down the degradation of Mg. Further osteogenic properties and in-vivo studies are required for validating this material for clinical use.
DescriptionSession: Research ‐ Miscellaneous I
Oral Presentation
Persistent Identifierhttp://hdl.handle.net/10722/165519

 

DC FieldValueLanguage
dc.contributor.authorWong, HMen_US
dc.contributor.authorYeung, Ken_US
dc.contributor.authorChu, Pen_US
dc.contributor.authorLuk, Ken_US
dc.contributor.authorCheung, Ken_US
dc.date.accessioned2012-09-20T08:19:19Z-
dc.date.available2012-09-20T08:19:19Z-
dc.date.issued2011en_US
dc.identifier.citationThe 25th Triennial World Congress (SICOT 2011), Prague, Czech Republic, 6-9 September 2011. In Abstract Book of 25th Triennial World Congress, SICOT 2011, p. abstract no. 29670en_US
dc.identifier.urihttp://hdl.handle.net/10722/165519-
dc.descriptionSession: Research ‐ Miscellaneous I-
dc.descriptionOral Presentation-
dc.description.abstractCurrently developed injectable materials such as calcium-based bone cements have tried to replace the conventional PMMA. However, their brittleness affects their stability and may cause another fracture. Hence, our group has recently fabricated an injectable biodegradable polycaprolactone (PCL) - magnesium (Mg) hybrids to solve the problems. A wide range of mechanical properties was obtained by altering the PCL and Mg composition. And the rapid degradation of Mg was suppressed by the silane coupling agent surface treatment. This study aims to investigate the mechanical and in-vitro properties of the newly developed hybrid. Four types of PCL-Mg hybrids were prepared by incorporating 0.1g and 0.6g Mg beads with and without silane treatment into 1g PCL, respectively. Compression test was conducted to evaluate the mechanical properties of the hybrids. Green fluorescent protein osteoblasts (GFPOB) were cultured on the hybrids for 1 and 3 day(s) to evaluate their cell attachment and proliferation. 1-fold and 3-fold higher compressive moduli were found on the 0.1g and 0.6g Mg-PCL hybrids with and without silane treatment than pure PCL, respectively, indicating that the mechanical property of pure PCL was enhanced by incorporating Mg beads. GFPOBs grew well on the hybrids except the untreated 0.6g Mg-PCL. This was probably due to the large release of Mg which may cause toxic effect. Hence, the results suggested that the silane treatment was able to slow down the degradation of Mg. Further osteogenic properties and in-vivo studies are required for validating this material for clinical use.-
dc.languageengen_US
dc.publisherInternational Society of Orthopaedic Surgery and Traumatology-
dc.relation.ispartofAbstract Book of 25th Triennial World Congress, SICOT 2011en_US
dc.titleA novel biodegradable injectable polycaprolactone-magnesium hybrid for orthopaedic implantationen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, HM: khmwong@hku.hken_US
dc.identifier.emailYeung, K: wkkyeung@hku.hken_US
dc.identifier.emailLuk, K: hcm21000@hku.hken_US
dc.identifier.emailCheung, K: cheungmc@hku.hken_US
dc.identifier.authorityYeung, K=rp00309en_US
dc.identifier.authorityLuk, K=rp00333en_US
dc.identifier.authorityCheung, K=rp00387en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros208424en_US
dc.identifier.hkuros204552-
dc.publisher.placeFrance-
dc.customcontrol.immutablesml 130514-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats