File Download
Supplementary

Conference Paper: Pathogenic level estimation of cervical myelopathy based on diffusion tensor imaging

TitlePathogenic level estimation of cervical myelopathy based on diffusion tensor imaging
Authors
Issue Date2011
PublisherSICOT 2011
Citation
The 25th Triennial World Congress (SICOT 2011), Prague, Czech Republic, 6-9 September 2011. In Abstract Book of 25th Triennial World Congress, SICOT 2011 How to Cite?
AbstractPURPOSE: The insidious onset and variety of clinical symptoms of cervical myelopathy (CM) pose a big challenge to clinician for early diagnosis and precise prognostication. The gross morphological and signal changes in T2-weighted magnetic resonance images (MRI) did not necessarily correlate with the severity of chronic compressive injuries of spinal cord. In the present study, we aimed to employ a relatively novel index in diffusion MR imaging directional entropy (DE) to investigate the potential pathogenic levels in CM patients. METHODS: Subjects Total 22 volunteers were recruited in this study with informed consent, including 8 CM patients (64±20yrs) and 14 healthy subjects (46±16yrs). Diffusion MR Imaging MR imaging were performed with a 3T MR system (Philips, Netherlands), by using pulsed gradient, spin-echo-echo-planar imaging sequence (data acquisition parameters: TR/TS=5000/60 ms; 13 slices (7mm slice thickness, 2.2mm gap); field of view= 80 (RL) ×36 (AP) mm; matrix size =128×128; non-collinear diffusion encoding directions=16, b=600s/mm2; reconstruction resolution= 0.63×0.63×7.0mm3). RESULTS: It was revealed the DE value in the myelopathy cord was significantly higher than healthy cord (p<0.05) at compression level (DE(0): 0.91±0.03) and adjacent three levels towards both rostral (DE(-3): 0.74±0.05; DE(-2): 0.82±0.05; DE(-1): 0.85±0.03) and caudal directions (DE(1): 0.83±0.05; DE(2): 0.81±0.06; DE(3): 0.79±0.05). The pathogenic probability was estimated in a multilevel case by extracted increment (C34: 31.6%; C45: 5.3%; C56: 40.5%; C67: 22.6%). CONCLUSION: The directional entropy successfully described and quantitatively measured the microstructural disorganization in the cervical myelopathy. It might be a novel approach for the pathogenic level estimation.
DescriptionFree Papers: Research ‐ Clinical II: abstract no. 28959
Persistent Identifierhttp://hdl.handle.net/10722/165515

 

DC FieldValueLanguage
dc.contributor.authorLuk, KDKen_US
dc.contributor.authorCui, Jen_US
dc.contributor.authorWen, Cen_US
dc.contributor.authorHu, Yen_US
dc.date.accessioned2012-09-20T08:19:18Z-
dc.date.available2012-09-20T08:19:18Z-
dc.date.issued2011en_US
dc.identifier.citationThe 25th Triennial World Congress (SICOT 2011), Prague, Czech Republic, 6-9 September 2011. In Abstract Book of 25th Triennial World Congress, SICOT 2011en_US
dc.identifier.urihttp://hdl.handle.net/10722/165515-
dc.descriptionFree Papers: Research ‐ Clinical II: abstract no. 28959-
dc.description.abstractPURPOSE: The insidious onset and variety of clinical symptoms of cervical myelopathy (CM) pose a big challenge to clinician for early diagnosis and precise prognostication. The gross morphological and signal changes in T2-weighted magnetic resonance images (MRI) did not necessarily correlate with the severity of chronic compressive injuries of spinal cord. In the present study, we aimed to employ a relatively novel index in diffusion MR imaging directional entropy (DE) to investigate the potential pathogenic levels in CM patients. METHODS: Subjects Total 22 volunteers were recruited in this study with informed consent, including 8 CM patients (64±20yrs) and 14 healthy subjects (46±16yrs). Diffusion MR Imaging MR imaging were performed with a 3T MR system (Philips, Netherlands), by using pulsed gradient, spin-echo-echo-planar imaging sequence (data acquisition parameters: TR/TS=5000/60 ms; 13 slices (7mm slice thickness, 2.2mm gap); field of view= 80 (RL) ×36 (AP) mm; matrix size =128×128; non-collinear diffusion encoding directions=16, b=600s/mm2; reconstruction resolution= 0.63×0.63×7.0mm3). RESULTS: It was revealed the DE value in the myelopathy cord was significantly higher than healthy cord (p<0.05) at compression level (DE(0): 0.91±0.03) and adjacent three levels towards both rostral (DE(-3): 0.74±0.05; DE(-2): 0.82±0.05; DE(-1): 0.85±0.03) and caudal directions (DE(1): 0.83±0.05; DE(2): 0.81±0.06; DE(3): 0.79±0.05). The pathogenic probability was estimated in a multilevel case by extracted increment (C34: 31.6%; C45: 5.3%; C56: 40.5%; C67: 22.6%). CONCLUSION: The directional entropy successfully described and quantitatively measured the microstructural disorganization in the cervical myelopathy. It might be a novel approach for the pathogenic level estimation.-
dc.languageengen_US
dc.publisherSICOT 2011-
dc.relation.ispartofAbstract Book of 25th Triennial World Congress, SICOT 2011en_US
dc.titlePathogenic level estimation of cervical myelopathy based on diffusion tensor imagingen_US
dc.typeConference_Paperen_US
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_US
dc.identifier.emailWen, C: paulwen@hku.hken_US
dc.identifier.emailHu, Y: yhud@hku.hken_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.identifier.authorityHu, Y=rp00432en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros208419en_US
dc.customcontrol.immutablesml 130514-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats