Conference Paper: The genetic landscape of immune-competent and HIV lymphoma

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TitleThe genetic landscape of immune-competent and HIV lymphoma
AuthorsZhang, J
Grubor, V
Love, CL
Banerjee, A
Richards, KL
Miezcowski, P
Dunphy, CH
Choi, WWL
Au, WY
Srivastava, G
Lugar, PL
Rizzieri, DA
Lagoo, AS
Bernal-Mizrachi, L
Mann, KP
Flowers, CR
Naresh, KN
Evens, AM
Gordon, LI
Czader, MB
Gill, JI
Hsi, ED
Liu, Q
Fan, A
Walsh, K
Jima, DD
Luftig, M
Ni, T
Zhu, J
Chadburn, A
Levy, S
Dunson, DB
Dave, SS
Issue Date2011
PublisherBioMed Central. The Journal's web site is located at http://www.infectagentscancer.com/home
CitationThe 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICAMAOI), Bethesda, MD., 7-8 November 2011. In Infectious Agents and Cancer, 2011, v. 7 suppl. 1, article no. O1 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1750-9378-7-S1-O1
AbstractBurkitt lymphoma (BL) and diffuse large B cell lymphoma (DLBCL) are aggressive forms of lymphoma in adults and demonstrate overlapping morphology, immunophenotype and clinical behavior. The risk of developing these tumors increases ten to hundred-fold in the setting of HIV infection. The genetic causes and the role of specific mutations, especially in the setting of HIV, are largely unknown. The decoding of the human genome and the advent of high-throughput sequencing have provided rich opportunities for the comprehensive identification of the genetic causes of cancer. In order to comprehensively identify genes that are recurrently mutated in immune-competent DLBCL and BL, we obtained a total of 92 cases of DLBCLs and 40 cases of BL. These cases were compared to a set of 5 DLBCLs and BL tumors derived from patients with HIV. The DLBCL cases were divided into a discovery set (N=34) and …
DescriptionThis journal supplement is Proceedings of the 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)
Open Access Journal
ISSN1750-9378
2011 SCImago Journal Rankings: 0.225
DOIhttp://dx.doi.org/10.1186/1750-9378-7-S1-O1
PubMed Central IDPMC3330083
DC Field
Value
dc.contributor.authorZhang, J
dc.contributor.authorGrubor, V
dc.contributor.authorLove, CL
dc.contributor.authorBanerjee, A
dc.contributor.authorRichards, KL
dc.contributor.authorMiezcowski, P
dc.contributor.authorDunphy, CH
dc.contributor.authorChoi, WWL
dc.contributor.authorAu, WY
dc.contributor.authorSrivastava, G
dc.contributor.authorLugar, PL
dc.contributor.authorRizzieri, DA
dc.contributor.authorLagoo, AS
dc.contributor.authorBernal-Mizrachi, L
dc.contributor.authorMann, KP
dc.contributor.authorFlowers, CR
dc.contributor.authorNaresh, KN
dc.contributor.authorEvens, AM
dc.contributor.authorGordon, LI
dc.contributor.authorCzader, MB
dc.contributor.authorGill, JI
dc.contributor.authorHsi, ED
dc.contributor.authorLiu, Q
dc.contributor.authorFan, A
dc.contributor.authorWalsh, K
dc.contributor.authorJima, DD
dc.contributor.authorLuftig, M
dc.contributor.authorNi, T
dc.contributor.authorZhu, J
dc.contributor.authorChadburn, A
dc.contributor.authorLevy, S
dc.contributor.authorDunson, DB
dc.contributor.authorDave, SS
dc.date.accessioned2012-09-20T08:18:20Z
dc.date.available2012-09-20T08:18:20Z
dc.date.issued2011
dc.description.abstractBurkitt lymphoma (BL) and diffuse large B cell lymphoma (DLBCL) are aggressive forms of lymphoma in adults and demonstrate overlapping morphology, immunophenotype and clinical behavior. The risk of developing these tumors increases ten to hundred-fold in the setting of HIV infection. The genetic causes and the role of specific mutations, especially in the setting of HIV, are largely unknown. The decoding of the human genome and the advent of high-throughput sequencing have provided rich opportunities for the comprehensive identification of the genetic causes of cancer. In order to comprehensively identify genes that are recurrently mutated in immune-competent DLBCL and BL, we obtained a total of 92 cases of DLBCLs and 40 cases of BL. These cases were compared to a set of 5 DLBCLs and BL tumors derived from patients with HIV. The DLBCL cases were divided into a discovery set (N=34) and …
dc.description.naturelink_to_OA_fulltext
dc.descriptionThis journal supplement is Proceedings of the 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)
dc.descriptionOpen Access Journal
dc.description.otherThe 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICAMAOI), Bethesda, MD., 7-8 November 2011. In Infectious Agents and Cancer, 2011, v. 7 suppl. 1, article no. O1
dc.identifier.citationThe 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICAMAOI), Bethesda, MD., 7-8 November 2011. In Infectious Agents and Cancer, 2011, v. 7 suppl. 1, article no. O1 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1750-9378-7-S1-O1
dc.identifier.doihttp://dx.doi.org/10.1186/1750-9378-7-S1-O1
dc.identifier.hkuros210936
dc.identifier.hkuros213480
dc.identifier.issn1750-9378
2011 SCImago Journal Rankings: 0.225
dc.identifier.issuesuppl. 1
dc.identifier.pmcidPMC3330083
dc.identifier.urihttp://hdl.handle.net/10722/165453
dc.identifier.volume7
dc.languageeng
dc.publisherBioMed Central. The Journal's web site is located at http://www.infectagentscancer.com/home
dc.publisher.placeUnited Kingdom
dc.relation.ispartofInfectious Agents and Cancer
dc.rightsInfectious Agents and Cancer. Copyright © BioMed Central.
dc.titleThe genetic landscape of immune-competent and HIV lymphoma
dc.typeConference_Paper