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Conference Paper: Emulsion electrospinning of nanofibrous delivery vehicles for the controlled release of biomolecules and the in vitro release behaviour of biomolecules

TitleEmulsion electrospinning of nanofibrous delivery vehicles for the controlled release of biomolecules and the in vitro release behaviour of biomolecules
Authors
KeywordsControlled-release
Core-shell structure
Emulsion electrospinning
Nano-fiber
Issue Date2011
PublisherTrans Tech Publications Ltd.. The Journal's web site is located at http://www.scitec.ch/1022-6680/
Citation
The 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM 2011), Hong Kong, 15-18 December 2011. In Advanced Materials Research, 2011, v. 410, p. 98-101 How to Cite?
AbstractElectrospinning is a popular technique for constructing nanofibrous tissue engineering scaffolds. Electrospinning is also amenable to the incorporation of drugs or biomolecules in fibers, which can provide local and sustained delivery of biological signals, such as growth factors, for the seeded cells. Drugs can normally be dissolved in polymer solutions for electrospinning, forming nanofibrous drug delivery systems. However, simply blending biomolecules in polymer solutions can result in denaturation of biomolecules and large initial burst release. Therefore, emulsion electrospinning, which can provide protection for biomolecules during electrospinning, is of great interest. In this investigation, biomolecule-containing scaffolds were emulsion electrospun using bovine serum albumin (BSA) as the model protein. Two polymers, poly (lactic-co-glycolic acid) and poly (D,L-lactic acid), were used due to their different degradation characteristics. Nanofibers with core-shell structures were electrospun from water-in-oil emulsions formulated by polymer solution, BSA-containing deionized water and a surfactant. By changing the polymer concentration and water phase volume, the fiber diameter and core-shell structure were varied. With different polymers and different fiber structures, the in vitro BSA release behaviours from fibrous scaffolds were different.
DescriptionThis series vol. has title: Processing and Fabrication of Advanced Materials: selected, peer reviewed papers from the 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM XX)
Persistent Identifierhttp://hdl.handle.net/10722/165377
ISBN
ISSN
2015 SCImago Journal Rankings: 0.115

 

DC FieldValueLanguage
dc.contributor.authorWang, Cen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-09-20T08:17:47Z-
dc.date.available2012-09-20T08:17:47Z-
dc.date.issued2011en_US
dc.identifier.citationThe 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM 2011), Hong Kong, 15-18 December 2011. In Advanced Materials Research, 2011, v. 410, p. 98-101en_US
dc.identifier.isbn978-3-03785-316-0-
dc.identifier.issn1022-6680-
dc.identifier.urihttp://hdl.handle.net/10722/165377-
dc.descriptionThis series vol. has title: Processing and Fabrication of Advanced Materials: selected, peer reviewed papers from the 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM XX)-
dc.description.abstractElectrospinning is a popular technique for constructing nanofibrous tissue engineering scaffolds. Electrospinning is also amenable to the incorporation of drugs or biomolecules in fibers, which can provide local and sustained delivery of biological signals, such as growth factors, for the seeded cells. Drugs can normally be dissolved in polymer solutions for electrospinning, forming nanofibrous drug delivery systems. However, simply blending biomolecules in polymer solutions can result in denaturation of biomolecules and large initial burst release. Therefore, emulsion electrospinning, which can provide protection for biomolecules during electrospinning, is of great interest. In this investigation, biomolecule-containing scaffolds were emulsion electrospun using bovine serum albumin (BSA) as the model protein. Two polymers, poly (lactic-co-glycolic acid) and poly (D,L-lactic acid), were used due to their different degradation characteristics. Nanofibers with core-shell structures were electrospun from water-in-oil emulsions formulated by polymer solution, BSA-containing deionized water and a surfactant. By changing the polymer concentration and water phase volume, the fiber diameter and core-shell structure were varied. With different polymers and different fiber structures, the in vitro BSA release behaviours from fibrous scaffolds were different.-
dc.languageengen_US
dc.publisherTrans Tech Publications Ltd.. The Journal's web site is located at http://www.scitec.ch/1022-6680/-
dc.relation.ispartofAdvanced Materials Researchen_US
dc.subjectControlled-release-
dc.subjectCore-shell structure-
dc.subjectEmulsion electrospinning-
dc.subjectNano-fiber-
dc.titleEmulsion electrospinning of nanofibrous delivery vehicles for the controlled release of biomolecules and the in vitro release behaviour of biomoleculesen_US
dc.typeConference_Paperen_US
dc.identifier.emailWang, C: mecwang@hku.hken_US
dc.identifier.emailWang, M: memwang@hku.hk-
dc.identifier.authorityWang, M=rp00185en_US
dc.identifier.doi10.4028/www.scientific.net/AMR.410.98-
dc.identifier.scopuseid_2-s2.0-84255195643-
dc.identifier.hkuros207475en_US
dc.identifier.hkuros207616-
dc.identifier.volume410-
dc.identifier.spage98en_US
dc.identifier.epage101en_US
dc.publisher.placeSwitzerland-
dc.description.otherThe 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM 2011), Hong Kong, 15-18 December 2011. In Advanced Materials Research, 2011, v. 410, p. 98-101-

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