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Conference Paper: Novel electrospun bicomponent scaffolds for bone tissue engineering: Fabrication, characterization and sustained release of growth factor
Title | Novel electrospun bicomponent scaffolds for bone tissue engineering: Fabrication, characterization and sustained release of growth factor |
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Authors | |
Keywords | Biological tissues Bone apatite Bone tissue engineering Burst release Cellular behaviors |
Issue Date | 2011 |
Publisher | Materials Research Society. The Journal's web site is located at http://www.mrs.org/publications/epubs/proceedings/spring2004/index.html |
Citation | The 2011 Fall Meeting & Exhibit of the Materials Research Society, Boston, MA., 28 November-2 December 2011. In Materials Research Society Symposium Proceedings, 2012, v. 1418, p. 151-162 How to Cite? |
Abstract | Electrospinning is a versatile technique for fabricating three-dimensional (3D) nanofibrous scaffolds and the scaffolds have been found to elicit desirable cellular behavior for tissue regeneration because the nanofibrous structures mimic the nanofibrous extracellular matrix (ECM) of biological tissues. From the material point of view, the ECM of bone is a nanofibrous nanocomposite consisting of an organic matrix (mainly collagen) and inorganic bone apatite nanoparticles. Therefore, for bone tissue engineering scaffolds, it is natural to construct nanofibrous nanocomposites having a biodegradable polymer matrix and nanosized bioactive bioceramics. Our previous studies demonstrated: (1) electrospun nanocomposite fiber loaded with calcium phosphate (Ca-P) were osteoconductive and could promote osteoblastic cell proliferation and differentiation better than pure polymer fibers; (2) The controlled release of recombinant human bone morphogenetic protein (rhBMP-2) from scaffolds provided the scaffolds with desired osteoinductivity. In the current investigation, novel bicomponent scaffolds for bone tissue engineering were produced using our established dual-source dual-power electrospinning technique to achieve both osteoconductivity and osteoinductivity. In the bicomponent scaffolds, one fibrous component was electrospun Ca-P/PLGA nanocomposite fibers and the other component was emulsion electrospun PDLLA nanofibers incorporated with rhBMP-2. Through electrospinning optimization, both fibers were evenly distributed in bicomponent scaffolds. The mass ratio of rhBMP-2/PDLLA fibers to Ca-P/PLGA fibers in bicomponent scaffolds could be controlled using multiple syringes. The structure and morphology of mono- and bicomponent scaffolds were examined. The in vitro release of rhBMP-2 from mono- and bicomponent scaffolds showed different release amount but similar release profile, exhibiting an initial burst release. Blending PDLLA with polyethylene glycol (PEG) could reduce the initial burst release of rhBMP-2. © 2012 Materials Research Society. |
Description | Gels and Biomedical Materials Symposium, Gels and Biomedical Materials |
Persistent Identifier | http://hdl.handle.net/10722/165362 |
ISBN | |
ISSN | 2019 SCImago Journal Rankings: 0.114 |
DC Field | Value | Language |
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dc.contributor.author | Wang, C | en_US |
dc.contributor.author | Wang, M | - |
dc.contributor.author | Yuan, XY | - |
dc.date.accessioned | 2012-09-20T08:17:44Z | - |
dc.date.available | 2012-09-20T08:17:44Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | The 2011 Fall Meeting & Exhibit of the Materials Research Society, Boston, MA., 28 November-2 December 2011. In Materials Research Society Symposium Proceedings, 2012, v. 1418, p. 151-162 | en_US |
dc.identifier.isbn | 978-160511395-1 | - |
dc.identifier.issn | 0272-9172 | - |
dc.identifier.uri | http://hdl.handle.net/10722/165362 | - |
dc.description | Gels and Biomedical Materials | - |
dc.description | Symposium, Gels and Biomedical Materials | - |
dc.description.abstract | Electrospinning is a versatile technique for fabricating three-dimensional (3D) nanofibrous scaffolds and the scaffolds have been found to elicit desirable cellular behavior for tissue regeneration because the nanofibrous structures mimic the nanofibrous extracellular matrix (ECM) of biological tissues. From the material point of view, the ECM of bone is a nanofibrous nanocomposite consisting of an organic matrix (mainly collagen) and inorganic bone apatite nanoparticles. Therefore, for bone tissue engineering scaffolds, it is natural to construct nanofibrous nanocomposites having a biodegradable polymer matrix and nanosized bioactive bioceramics. Our previous studies demonstrated: (1) electrospun nanocomposite fiber loaded with calcium phosphate (Ca-P) were osteoconductive and could promote osteoblastic cell proliferation and differentiation better than pure polymer fibers; (2) The controlled release of recombinant human bone morphogenetic protein (rhBMP-2) from scaffolds provided the scaffolds with desired osteoinductivity. In the current investigation, novel bicomponent scaffolds for bone tissue engineering were produced using our established dual-source dual-power electrospinning technique to achieve both osteoconductivity and osteoinductivity. In the bicomponent scaffolds, one fibrous component was electrospun Ca-P/PLGA nanocomposite fibers and the other component was emulsion electrospun PDLLA nanofibers incorporated with rhBMP-2. Through electrospinning optimization, both fibers were evenly distributed in bicomponent scaffolds. The mass ratio of rhBMP-2/PDLLA fibers to Ca-P/PLGA fibers in bicomponent scaffolds could be controlled using multiple syringes. The structure and morphology of mono- and bicomponent scaffolds were examined. The in vitro release of rhBMP-2 from mono- and bicomponent scaffolds showed different release amount but similar release profile, exhibiting an initial burst release. Blending PDLLA with polyethylene glycol (PEG) could reduce the initial burst release of rhBMP-2. © 2012 Materials Research Society. | - |
dc.language | eng | en_US |
dc.publisher | Materials Research Society. The Journal's web site is located at http://www.mrs.org/publications/epubs/proceedings/spring2004/index.html | - |
dc.relation.ispartof | Materials Research Society Symposium Proceedings | en_US |
dc.rights | Materials Research Society Symposium Proceedings. Copyright © Materials Research Society. | - |
dc.subject | Biological tissues | - |
dc.subject | Bone apatite | - |
dc.subject | Bone tissue engineering | - |
dc.subject | Burst release | - |
dc.subject | Cellular behaviors | - |
dc.title | Novel electrospun bicomponent scaffolds for bone tissue engineering: Fabrication, characterization and sustained release of growth factor | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wang, M: memwang@hku.hk | en_US |
dc.identifier.authority | Wang, M=rp00185 | en_US |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1557/opl.2012.395 | - |
dc.identifier.scopus | eid_2-s2.0-84865006697 | - |
dc.identifier.hkuros | 207569 | en_US |
dc.identifier.volume | 1418 | - |
dc.identifier.spage | 151 | en_US |
dc.identifier.epage | 162 | en_US |
dc.publisher.place | United States | - |
dc.customcontrol.immutable | sml 130918 | - |
dc.identifier.issnl | 0272-9172 | - |