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Conference Paper: Novel electrospun bicomponent scaffolds for bone tissue engineering: Fabrication, characterization and sustained release of growth factor

TitleNovel electrospun bicomponent scaffolds for bone tissue engineering: Fabrication, characterization and sustained release of growth factor
Authors
KeywordsBiological tissues
Bone apatite
Bone tissue engineering
Burst release
Cellular behaviors
Issue Date2011
PublisherMaterials Research Society. The Journal's web site is located at http://www.mrs.org/publications/epubs/proceedings/spring2004/index.html
Citation
The 2011 Fall Meeting & Exhibit of the Materials Research Society, Boston, MA., 28 November-2 December 2011. In Materials Research Society Symposium Proceedings, 2012, v. 1418, p. 151-162 How to Cite?
AbstractElectrospinning is a versatile technique for fabricating three-dimensional (3D) nanofibrous scaffolds and the scaffolds have been found to elicit desirable cellular behavior for tissue regeneration because the nanofibrous structures mimic the nanofibrous extracellular matrix (ECM) of biological tissues. From the material point of view, the ECM of bone is a nanofibrous nanocomposite consisting of an organic matrix (mainly collagen) and inorganic bone apatite nanoparticles. Therefore, for bone tissue engineering scaffolds, it is natural to construct nanofibrous nanocomposites having a biodegradable polymer matrix and nanosized bioactive bioceramics. Our previous studies demonstrated: (1) electrospun nanocomposite fiber loaded with calcium phosphate (Ca-P) were osteoconductive and could promote osteoblastic cell proliferation and differentiation better than pure polymer fibers; (2) The controlled release of recombinant human bone morphogenetic protein (rhBMP-2) from scaffolds provided the scaffolds with desired osteoinductivity. In the current investigation, novel bicomponent scaffolds for bone tissue engineering were produced using our established dual-source dual-power electrospinning technique to achieve both osteoconductivity and osteoinductivity. In the bicomponent scaffolds, one fibrous component was electrospun Ca-P/PLGA nanocomposite fibers and the other component was emulsion electrospun PDLLA nanofibers incorporated with rhBMP-2. Through electrospinning optimization, both fibers were evenly distributed in bicomponent scaffolds. The mass ratio of rhBMP-2/PDLLA fibers to Ca-P/PLGA fibers in bicomponent scaffolds could be controlled using multiple syringes. The structure and morphology of mono- and bicomponent scaffolds were examined. The in vitro release of rhBMP-2 from mono- and bicomponent scaffolds showed different release amount but similar release profile, exhibiting an initial burst release. Blending PDLLA with polyethylene glycol (PEG) could reduce the initial burst release of rhBMP-2. © 2012 Materials Research Society.
DescriptionGels and Biomedical Materials
Symposium, Gels and Biomedical Materials
Persistent Identifierhttp://hdl.handle.net/10722/165362
ISBN
ISSN

 

DC FieldValueLanguage
dc.contributor.authorWang, Cen_US
dc.contributor.authorWang, M-
dc.contributor.authorYuan, XY-
dc.date.accessioned2012-09-20T08:17:44Z-
dc.date.available2012-09-20T08:17:44Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Fall Meeting & Exhibit of the Materials Research Society, Boston, MA., 28 November-2 December 2011. In Materials Research Society Symposium Proceedings, 2012, v. 1418, p. 151-162en_US
dc.identifier.isbn978-160511395-1-
dc.identifier.issn0272-9172-
dc.identifier.urihttp://hdl.handle.net/10722/165362-
dc.descriptionGels and Biomedical Materials-
dc.descriptionSymposium, Gels and Biomedical Materials-
dc.description.abstractElectrospinning is a versatile technique for fabricating three-dimensional (3D) nanofibrous scaffolds and the scaffolds have been found to elicit desirable cellular behavior for tissue regeneration because the nanofibrous structures mimic the nanofibrous extracellular matrix (ECM) of biological tissues. From the material point of view, the ECM of bone is a nanofibrous nanocomposite consisting of an organic matrix (mainly collagen) and inorganic bone apatite nanoparticles. Therefore, for bone tissue engineering scaffolds, it is natural to construct nanofibrous nanocomposites having a biodegradable polymer matrix and nanosized bioactive bioceramics. Our previous studies demonstrated: (1) electrospun nanocomposite fiber loaded with calcium phosphate (Ca-P) were osteoconductive and could promote osteoblastic cell proliferation and differentiation better than pure polymer fibers; (2) The controlled release of recombinant human bone morphogenetic protein (rhBMP-2) from scaffolds provided the scaffolds with desired osteoinductivity. In the current investigation, novel bicomponent scaffolds for bone tissue engineering were produced using our established dual-source dual-power electrospinning technique to achieve both osteoconductivity and osteoinductivity. In the bicomponent scaffolds, one fibrous component was electrospun Ca-P/PLGA nanocomposite fibers and the other component was emulsion electrospun PDLLA nanofibers incorporated with rhBMP-2. Through electrospinning optimization, both fibers were evenly distributed in bicomponent scaffolds. The mass ratio of rhBMP-2/PDLLA fibers to Ca-P/PLGA fibers in bicomponent scaffolds could be controlled using multiple syringes. The structure and morphology of mono- and bicomponent scaffolds were examined. The in vitro release of rhBMP-2 from mono- and bicomponent scaffolds showed different release amount but similar release profile, exhibiting an initial burst release. Blending PDLLA with polyethylene glycol (PEG) could reduce the initial burst release of rhBMP-2. © 2012 Materials Research Society.-
dc.languageengen_US
dc.publisherMaterials Research Society. The Journal's web site is located at http://www.mrs.org/publications/epubs/proceedings/spring2004/index.html-
dc.relation.ispartofMaterials Research Society Symposium Proceedingsen_US
dc.rightsMaterials Research Society Symposium Proceedings. Copyright © Materials Research Society.-
dc.subjectBiological tissues-
dc.subjectBone apatite-
dc.subjectBone tissue engineering-
dc.subjectBurst release-
dc.subjectCellular behaviors-
dc.titleNovel electrospun bicomponent scaffolds for bone tissue engineering: Fabrication, characterization and sustained release of growth factoren_US
dc.typeConference_Paperen_US
dc.identifier.emailWang, M: memwang@hku.hken_US
dc.identifier.authorityWang, M=rp00185en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1557/opl.2012.395-
dc.identifier.scopuseid_2-s2.0-84865006697-
dc.identifier.hkuros207569en_US
dc.identifier.volume1418-
dc.identifier.spage151en_US
dc.identifier.epage162en_US
dc.publisher.placeUnited States-
dc.customcontrol.immutablesml 130918-

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