Conference Paper: 1H-MRS investigation of IMCL storage during resting in skeletal muscle: obese versus normal rats
| Title | 1H-MRS investigation of IMCL storage during resting in skeletal muscle: obese versus normal rats |
|---|---|
| Authors | Qiao, Z Cao, P Wang, AM Xie, VB Fan, S Wu, EX |
| Issue Date | 2012 |
| Publisher | International Society of Magnetic Resonance in Medicine. |
| Citation | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0062 [How to Cite?] |
| Abstract | In this study, we hypothesized that the gradual IMCL storage occurs in skeletal muscle during resting, and such storage at resting state would alter in obesity. Specifically, we investigated the IMCL storage at resting state in obese rats by quantifying the rates of IMCL accumulation using continuous and dynamic 1H-MRS. We demonstrated that dynamic 1H-MRS could quantify the IMCL accumulation at resting state in individual muscles. Our preliminary results revealed that the disorder of lipid metabolism in obesity is associated with not only an increased IMCL content, but also the alterations in the rates of IMCL storage at resting state in both slow-oxidative muscle and fast-oxidative glycolytic muscles. |
| Description | Theme: Adapting MR in a Changing World Oral Presentation - Session 06: MRS of Disease, Injury & Pathology in the Body & MSK: no. 0062 |
| dc.contributor.author | Qiao, Z |
|---|---|
| dc.contributor.author | Cao, P |
| dc.contributor.author | Wang, AM |
| dc.contributor.author | Xie, VB |
| dc.contributor.author | Fan, S |
| dc.contributor.author | Wu, EX |
| dc.date.accessioned | 2012-09-20T08:16:15Z |
| dc.date.available | 2012-09-20T08:16:15Z |
| dc.date.issued | 2012 |
| dc.description.abstract | In this study, we hypothesized that the gradual IMCL storage occurs in skeletal muscle during resting, and such storage at resting state would alter in obesity. Specifically, we investigated the IMCL storage at resting state in obese rats by quantifying the rates of IMCL accumulation using continuous and dynamic 1H-MRS. We demonstrated that dynamic 1H-MRS could quantify the IMCL accumulation at resting state in individual muscles. Our preliminary results revealed that the disorder of lipid metabolism in obesity is associated with not only an increased IMCL content, but also the alterations in the rates of IMCL storage at resting state in both slow-oxidative muscle and fast-oxidative glycolytic muscles. |
| dc.description.nature | link_to_OA_fulltext |
| dc.description | Theme: Adapting MR in a Changing World |
| dc.description | Oral Presentation - Session 06: MRS of Disease, Injury & Pathology in the Body & MSK: no. 0062 |
| dc.description.other | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0062 |
| dc.identifier.citation | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0062 [How to Cite?] |
| dc.identifier.hkuros | 207500 |
| dc.identifier.uri | http://hdl.handle.net/10722/165206 |
| dc.language | eng |
| dc.publisher | International Society of Magnetic Resonance in Medicine. |
| dc.publisher.place | Australia |
| dc.relation.ispartof | Proceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012 |
| dc.title | 1H-MRS investigation of IMCL storage during resting in skeletal muscle: obese versus normal rats |
| dc.type | Conference_Paper |