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Conference Paper: Investigation of restricted diffusion behaviour of intramyocellular lipids in skeletal muscle

TitleInvestigation of restricted diffusion behaviour of intramyocellular lipids in skeletal muscle
Authors
Issue Date2012
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3259 How to Cite?
Abstract
In skeletal muscle, lipids are stored as intramyocellular lipid (IMCL) inside muscle cells and extramyocellular lipid (EMCL) in large adipocytes. IMCL exists in form of small spherical droplets that are often found next to mitochondria. In this study, we aimed to characterize the lipid diffusion within IMCL droplet. Our experimental results demonstrated that small IMCL microstructure leads to highly restricted lipid diffusion in IMCL droplet. Such IMCL diffusion characterization may provide a sensitive maker to probe the IMCL droplet microstructure, leading to a potentially valuable tool for investigating IMCL droplet dynamics and metabolism in vivo.
DescriptionTheme: Adapting MR in a Changing World
Persistent Identifierhttp://hdl.handle.net/10722/165204

 

DC FieldValueLanguage
dc.contributor.authorCao, Pen_US
dc.contributor.authorQiao, Zen_US
dc.contributor.authorWang, AMen_US
dc.contributor.authorFan, Sen_US
dc.contributor.authorXie, VBen_US
dc.contributor.authorYang, Jen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2012-09-20T08:16:14Z-
dc.date.available2012-09-20T08:16:14Z-
dc.date.issued2012en_US
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3259en_US
dc.identifier.urihttp://hdl.handle.net/10722/165204-
dc.descriptionTheme: Adapting MR in a Changing World-
dc.descriptionElectronic Poster Session - Musculoskeletal - Muscle: no. 3259 (computer no. 11)-
dc.descriptionMagna Cum Laude Merit Award-
dc.description.abstractIn skeletal muscle, lipids are stored as intramyocellular lipid (IMCL) inside muscle cells and extramyocellular lipid (EMCL) in large adipocytes. IMCL exists in form of small spherical droplets that are often found next to mitochondria. In this study, we aimed to characterize the lipid diffusion within IMCL droplet. Our experimental results demonstrated that small IMCL microstructure leads to highly restricted lipid diffusion in IMCL droplet. Such IMCL diffusion characterization may provide a sensitive maker to probe the IMCL droplet microstructure, leading to a potentially valuable tool for investigating IMCL droplet dynamics and metabolism in vivo.-
dc.languageengen_US
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012en_US
dc.titleInvestigation of restricted diffusion behaviour of intramyocellular lipids in skeletal muscleen_US
dc.typeConference_Paperen_US
dc.identifier.emailQiao, Z: zwqiao@hku.hken_US
dc.identifier.emailFan, S: fanshj08@hkucc.hku.hk-
dc.identifier.emailYang, J: yj1118@hkucc.hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros207497en_US
dc.publisher.placeAustralia-
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3259-

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