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Conference Paper: Investigation of restricted diffusion behaviour of intramyocellular lipids in skeletal muscle
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TitleInvestigation of restricted diffusion behaviour of intramyocellular lipids in skeletal muscle
 
AuthorsCao, P
Qiao, Z
Wang, AM
Fan, S
Xie, VB
Yang, J
Wu, EX
 
Issue Date2012
 
PublisherInternational Society of Magnetic Resonance in Medicine.
 
CitationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3259 [How to Cite?]
 
AbstractIn skeletal muscle, lipids are stored as intramyocellular lipid (IMCL) inside muscle cells and extramyocellular lipid (EMCL) in large adipocytes. IMCL exists in form of small spherical droplets that are often found next to mitochondria. In this study, we aimed to characterize the lipid diffusion within IMCL droplet. Our experimental results demonstrated that small IMCL microstructure leads to highly restricted lipid diffusion in IMCL droplet. Such IMCL diffusion characterization may provide a sensitive maker to probe the IMCL droplet microstructure, leading to a potentially valuable tool for investigating IMCL droplet dynamics and metabolism in vivo.
 
DescriptionTheme: Adapting MR in a Changing World
Electronic Poster Session - Musculoskeletal - Muscle: no. 3259 (computer no. 11)
Magna Cum Laude Merit Award
 
DC FieldValue
dc.contributor.authorCao, P
 
dc.contributor.authorQiao, Z
 
dc.contributor.authorWang, AM
 
dc.contributor.authorFan, S
 
dc.contributor.authorXie, VB
 
dc.contributor.authorYang, J
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2012-09-20T08:16:14Z
 
dc.date.available2012-09-20T08:16:14Z
 
dc.date.issued2012
 
dc.description.abstractIn skeletal muscle, lipids are stored as intramyocellular lipid (IMCL) inside muscle cells and extramyocellular lipid (EMCL) in large adipocytes. IMCL exists in form of small spherical droplets that are often found next to mitochondria. In this study, we aimed to characterize the lipid diffusion within IMCL droplet. Our experimental results demonstrated that small IMCL microstructure leads to highly restricted lipid diffusion in IMCL droplet. Such IMCL diffusion characterization may provide a sensitive maker to probe the IMCL droplet microstructure, leading to a potentially valuable tool for investigating IMCL droplet dynamics and metabolism in vivo.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionTheme: Adapting MR in a Changing World
 
dc.descriptionElectronic Poster Session - Musculoskeletal - Muscle: no. 3259 (computer no. 11)
 
dc.descriptionMagna Cum Laude Merit Award
 
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3259
 
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3259 [How to Cite?]
 
dc.identifier.hkuros207497
 
dc.identifier.urihttp://hdl.handle.net/10722/165204
 
dc.languageeng
 
dc.publisherInternational Society of Magnetic Resonance in Medicine.
 
dc.publisher.placeAustralia
 
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012
 
dc.titleInvestigation of restricted diffusion behaviour of intramyocellular lipids in skeletal muscle
 
dc.typeConference_Paper
 
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<contributor.author>Xie, VB</contributor.author>
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<description>Magna Cum Laude Merit Award</description>
<description.abstract>In skeletal muscle, lipids are stored as intramyocellular lipid (IMCL) inside muscle cells and extramyocellular lipid (EMCL) in large adipocytes. IMCL exists in form of small spherical droplets that are often found next to mitochondria. In this study, we aimed to characterize the lipid diffusion within IMCL droplet. Our experimental results demonstrated that small IMCL microstructure leads to highly restricted lipid diffusion in IMCL droplet. Such IMCL diffusion characterization may provide a sensitive maker to probe the IMCL droplet microstructure, leading to a potentially valuable tool for investigating IMCL droplet dynamics and metabolism in vivo.</description.abstract>
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