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Conference Paper: Diffusion investigation of intramyocellular lipid droplet changes in skeletal muscle under fasting condition
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TitleDiffusion investigation of intramyocellular lipid droplet changes in skeletal muscle under fasting condition
 
AuthorsCao, P
Qiao, Z
Wang, AM
Fan, S
Xie, VB
Yang, J
Wu, EX
 
Issue Date2012
 
PublisherInternational Society of Magnetic Resonance in Medicine.
 
CitationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0063 [How to Cite?]
 
AbstractBiophysical properties of intramyocellular lipid (IMCL) such as droplet size may reflect the balance between droplet synthesis and degradation. In this study, we hypothesized that characterizing the restricted diffusion of IMCL protons could serve as a sensitive marker for monitoring IMCL droplet dynamics during metabolic intervention/abnormality. Our experimental results demonstrated that in vivo IMCL diffusion characteristics are sensitive to metabolic manipulation by fasting. During the 60-hr fasting, IMCL level increased but exhibited more restricted diffusion, largely in agreement with our histological observation of more droplets but of smaller sizes. Such IMCL diffusion characterization may serve as a sensitive marker to probe the IMCL droplet dynamics in vivo.
 
DescriptionTheme: Adapting MR in a Changing World
Oral Presentation - Session 06: MRS of Disease, Injury & Pathology in the Body & MSK: no. 0063
Summa Cum Laude Merit Award
 
DC FieldValue
dc.contributor.authorCao, P
 
dc.contributor.authorQiao, Z
 
dc.contributor.authorWang, AM
 
dc.contributor.authorFan, S
 
dc.contributor.authorXie, VB
 
dc.contributor.authorYang, J
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2012-09-20T08:16:14Z
 
dc.date.available2012-09-20T08:16:14Z
 
dc.date.issued2012
 
dc.description.abstractBiophysical properties of intramyocellular lipid (IMCL) such as droplet size may reflect the balance between droplet synthesis and degradation. In this study, we hypothesized that characterizing the restricted diffusion of IMCL protons could serve as a sensitive marker for monitoring IMCL droplet dynamics during metabolic intervention/abnormality. Our experimental results demonstrated that in vivo IMCL diffusion characteristics are sensitive to metabolic manipulation by fasting. During the 60-hr fasting, IMCL level increased but exhibited more restricted diffusion, largely in agreement with our histological observation of more droplets but of smaller sizes. Such IMCL diffusion characterization may serve as a sensitive marker to probe the IMCL droplet dynamics in vivo.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionTheme: Adapting MR in a Changing World
 
dc.descriptionOral Presentation - Session 06: MRS of Disease, Injury & Pathology in the Body & MSK: no. 0063
 
dc.descriptionSumma Cum Laude Merit Award
 
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0063
 
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0063 [How to Cite?]
 
dc.identifier.hkuros207496
 
dc.identifier.urihttp://hdl.handle.net/10722/165203
 
dc.languageeng
 
dc.publisherInternational Society of Magnetic Resonance in Medicine.
 
dc.publisher.placeAustralia
 
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012
 
dc.titleDiffusion investigation of intramyocellular lipid droplet changes in skeletal muscle under fasting condition
 
dc.typeConference_Paper
 
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