Conference Paper: Diffusion investigation of intramyocellular lipid droplet changes in skeletal muscle under fasting condition
| Title | Diffusion investigation of intramyocellular lipid droplet changes in skeletal muscle under fasting condition |
|---|---|
| Authors | Cao, P Qiao, Z Wang, AM Fan, S Xie, VB Yang, J Wu, EX |
| Issue Date | 2012 |
| Publisher | International Society of Magnetic Resonance in Medicine. |
| Citation | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0063 [How to Cite?] |
| Abstract | Biophysical properties of intramyocellular lipid (IMCL) such as droplet size may reflect the balance between droplet synthesis and degradation. In this study, we hypothesized that characterizing the restricted diffusion of IMCL protons could serve as a sensitive marker for monitoring IMCL droplet dynamics during metabolic intervention/abnormality. Our experimental results demonstrated that in vivo IMCL diffusion characteristics are sensitive to metabolic manipulation by fasting. During the 60-hr fasting, IMCL level increased but exhibited more restricted diffusion, largely in agreement with our histological observation of more droplets but of smaller sizes. Such IMCL diffusion characterization may serve as a sensitive marker to probe the IMCL droplet dynamics in vivo. |
| Description | Theme: Adapting MR in a Changing World Oral Presentation - Session 06: MRS of Disease, Injury & Pathology in the Body & MSK: no. 0063 Summa Cum Laude Merit Award |
| dc.contributor.author | Cao, P |
|---|---|
| dc.contributor.author | Qiao, Z |
| dc.contributor.author | Wang, AM |
| dc.contributor.author | Fan, S |
| dc.contributor.author | Xie, VB |
| dc.contributor.author | Yang, J |
| dc.contributor.author | Wu, EX |
| dc.date.accessioned | 2012-09-20T08:16:14Z |
| dc.date.available | 2012-09-20T08:16:14Z |
| dc.date.issued | 2012 |
| dc.description.abstract | Biophysical properties of intramyocellular lipid (IMCL) such as droplet size may reflect the balance between droplet synthesis and degradation. In this study, we hypothesized that characterizing the restricted diffusion of IMCL protons could serve as a sensitive marker for monitoring IMCL droplet dynamics during metabolic intervention/abnormality. Our experimental results demonstrated that in vivo IMCL diffusion characteristics are sensitive to metabolic manipulation by fasting. During the 60-hr fasting, IMCL level increased but exhibited more restricted diffusion, largely in agreement with our histological observation of more droplets but of smaller sizes. Such IMCL diffusion characterization may serve as a sensitive marker to probe the IMCL droplet dynamics in vivo. |
| dc.description.nature | link_to_OA_fulltext |
| dc.description | Theme: Adapting MR in a Changing World |
| dc.description | Oral Presentation - Session 06: MRS of Disease, Injury & Pathology in the Body & MSK: no. 0063 |
| dc.description | Summa Cum Laude Merit Award |
| dc.description.other | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0063 |
| dc.identifier.citation | The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0063 [How to Cite?] |
| dc.identifier.hkuros | 207496 |
| dc.identifier.uri | http://hdl.handle.net/10722/165203 |
| dc.language | eng |
| dc.publisher | International Society of Magnetic Resonance in Medicine. |
| dc.publisher.place | Australia |
| dc.relation.ispartof | Proceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012 |
| dc.title | Diffusion investigation of intramyocellular lipid droplet changes in skeletal muscle under fasting condition |
| dc.type | Conference_Paper |