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Conference Paper: Diffusion investigation of intramyocellular lipid droplet changes in skeletal muscle under fasting condition

TitleDiffusion investigation of intramyocellular lipid droplet changes in skeletal muscle under fasting condition
Authors
Issue Date2012
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0063 How to Cite?
Abstract
Biophysical properties of intramyocellular lipid (IMCL) such as droplet size may reflect the balance between droplet synthesis and degradation. In this study, we hypothesized that characterizing the restricted diffusion of IMCL protons could serve as a sensitive marker for monitoring IMCL droplet dynamics during metabolic intervention/abnormality. Our experimental results demonstrated that in vivo IMCL diffusion characteristics are sensitive to metabolic manipulation by fasting. During the 60-hr fasting, IMCL level increased but exhibited more restricted diffusion, largely in agreement with our histological observation of more droplets but of smaller sizes. Such IMCL diffusion characterization may serve as a sensitive marker to probe the IMCL droplet dynamics in vivo.
DescriptionTheme: Adapting MR in a Changing World
Persistent Identifierhttp://hdl.handle.net/10722/165203

 

DC FieldValueLanguage
dc.contributor.authorCao, Pen_US
dc.contributor.authorQiao, Zen_US
dc.contributor.authorWang, AMen_US
dc.contributor.authorFan, Sen_US
dc.contributor.authorXie, VBen_US
dc.contributor.authorYang, Jen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2012-09-20T08:16:14Z-
dc.date.available2012-09-20T08:16:14Z-
dc.date.issued2012en_US
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0063en_US
dc.identifier.urihttp://hdl.handle.net/10722/165203-
dc.descriptionTheme: Adapting MR in a Changing World-
dc.descriptionOral Presentation - Session 06: MRS of Disease, Injury & Pathology in the Body & MSK: no. 0063-
dc.descriptionSumma Cum Laude Merit Award-
dc.description.abstractBiophysical properties of intramyocellular lipid (IMCL) such as droplet size may reflect the balance between droplet synthesis and degradation. In this study, we hypothesized that characterizing the restricted diffusion of IMCL protons could serve as a sensitive marker for monitoring IMCL droplet dynamics during metabolic intervention/abnormality. Our experimental results demonstrated that in vivo IMCL diffusion characteristics are sensitive to metabolic manipulation by fasting. During the 60-hr fasting, IMCL level increased but exhibited more restricted diffusion, largely in agreement with our histological observation of more droplets but of smaller sizes. Such IMCL diffusion characterization may serve as a sensitive marker to probe the IMCL droplet dynamics in vivo.-
dc.languageengen_US
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012en_US
dc.titleDiffusion investigation of intramyocellular lipid droplet changes in skeletal muscle under fasting conditionen_US
dc.typeConference_Paperen_US
dc.identifier.emailQiao, Z: zwqiao@hku.hken_US
dc.identifier.emailFan, S: fanshj08@hkucc.hku.hk-
dc.identifier.emailYang, J: yj1118@hkucc.hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros207496en_US
dc.publisher.placeAustralia-
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0063-

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