Conference Paper: Effect of b-value on DTI sensitivity in revealing myocardial structure degradation in rabbit models with acute myocardium infarction

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Title	Effect of b-value on DTI sensitivity in revealing myocardial structure degradation in rabbit models with acute myocardium infarction
Authors	Wu, Y Zou, C Liu, W Liao, WQ Wu, EX
Issue Date	2012
Publisher	International Society of Magnetic Resonance in Medicine.
Citation	The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 1858 [How to Cite?]
Abstract	The free Gaussian process of water diffusion assumed in conventional DTI was found to not apply with increase of diffusion strength. In this study, effect of b-value on detecting myocardial structural alteration was assessed in infarcted rabbit models. Non-monoexponential diffusion manner was confirmed in both infarct and control groups. FA and radial diffusivity were found to alter significantly in infarct and/or adjacent regions, and the sensitivity to detect their statistical differences among all the groups were b-value dependent with the greatest total number of statistical significances occurred at b-values of 750 to 2000 s/mm2. The study demonstrated the important effect of diffusion strength on DTI index characterization and emphasized the necessity of optimizing b-value for better monitoring and detecting myocardial structural degradation.
Description	Theme: Adapting MR in a Changing World Traditional Poster Session - Diffusion & Perfusion - Body Diffusion: no. 1858

DC Field	Value
dc.contributor.author	Wu, Y
dc.contributor.author	Zou, C
dc.contributor.author	Liu, W
dc.contributor.author	Liao, WQ
dc.contributor.author	Wu, EX
dc.date.accessioned	2012-09-20T08:16:12Z
dc.date.available	2012-09-20T08:16:12Z
dc.date.issued	2012
dc.description.abstract	The free Gaussian process of water diffusion assumed in conventional DTI was found to not apply with increase of diffusion strength. In this study, effect of b-value on detecting myocardial structural alteration was assessed in infarcted rabbit models. Non-monoexponential diffusion manner was confirmed in both infarct and control groups. FA and radial diffusivity were found to alter significantly in infarct and/or adjacent regions, and the sensitivity to detect their statistical differences among all the groups were b-value dependent with the greatest total number of statistical significances occurred at b-values of 750 to 2000 s/mm2. The study demonstrated the important effect of diffusion strength on DTI index characterization and emphasized the necessity of optimizing b-value for better monitoring and detecting myocardial structural degradation.
dc.description.nature	link_to_OA_fulltext
dc.description	Theme: Adapting MR in a Changing World
dc.description	Traditional Poster Session - Diffusion & Perfusion - Body Diffusion: no. 1858
dc.description.other	The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 1858
dc.identifier.citation	The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 1858 [How to Cite?]
dc.identifier.hkuros	207488
dc.identifier.uri	http://hdl.handle.net/10722/165199
dc.language	eng
dc.publisher	International Society of Magnetic Resonance in Medicine.
dc.publisher.place	Australia
dc.relation.ispartof	Proceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012
dc.title	Effect of b-value on DTI sensitivity in revealing myocardial structure degradation in rabbit models with acute myocardium infarction
dc.type	Conference_Paper

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