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Conference Paper: Differentiation of primary and secondary degeneration in the visual pathway using in vivo Mn-enhanced MRI

TitleDifferentiation of primary and secondary degeneration in the visual pathway using in vivo Mn-enhanced MRI
Authors
Issue Date2012
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In proceedings of the 20th ISMRM, 2012, no. 0949 How to Cite?
Abstract
This study explores the capability of high-resolution Mn-enhanced MRI (MEMRI) for in vivo, longitudinal evaluation of primary and secondary degeneration along the retinocollicular projections after partial transection of right superior optic nerve in rats. At 1 week and 6 weeks after partial optic nerve injury, a consistent T1W hypointensity by about 28% was observed in the left lateral superior colliculus (SC) relative to the contralateral hemisphere, reflective of primary loss of topological connections and Mn2+ transport in the retinocollicular projections. The left medial SC had a reduced T1W signal intensity by 11% compared to the right medial SC at Week 1. Such reduction further increased to 16% at Week 6, indicative of secondary loss of retinal ganglion cells and axons projecting through the uninjured, inferior optic nerve. The results of this study demonstrated the feasibility of in vivo, high-resolution MEMRI for assessing the primary and secondary degeneration topologically and longitudinally along the visual pathway. Future MEMRI studies are envisioned that measure the secondary changes in topological connections in various neurodegenerative diseases and injuries and upon therapeutic interventions in longitudinal studies.
DescriptionTheme: Adapting MR in a Changing World
Persistent Identifierhttp://hdl.handle.net/10722/165194

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorZhou, IYen_US
dc.contributor.authorKau, Pen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2012-09-20T08:16:11Z-
dc.date.available2012-09-20T08:16:11Z-
dc.date.issued2012en_US
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In proceedings of the 20th ISMRM, 2012, no. 0949en_US
dc.identifier.urihttp://hdl.handle.net/10722/165194-
dc.descriptionTheme: Adapting MR in a Changing World-
dc.descriptionTraditional Poster Session - Neuro B: Manganese Enhanced MRI (MEMRI): no. 0949-
dc.description.abstractThis study explores the capability of high-resolution Mn-enhanced MRI (MEMRI) for in vivo, longitudinal evaluation of primary and secondary degeneration along the retinocollicular projections after partial transection of right superior optic nerve in rats. At 1 week and 6 weeks after partial optic nerve injury, a consistent T1W hypointensity by about 28% was observed in the left lateral superior colliculus (SC) relative to the contralateral hemisphere, reflective of primary loss of topological connections and Mn2+ transport in the retinocollicular projections. The left medial SC had a reduced T1W signal intensity by 11% compared to the right medial SC at Week 1. Such reduction further increased to 16% at Week 6, indicative of secondary loss of retinal ganglion cells and axons projecting through the uninjured, inferior optic nerve. The results of this study demonstrated the feasibility of in vivo, high-resolution MEMRI for assessing the primary and secondary degeneration topologically and longitudinally along the visual pathway. Future MEMRI studies are envisioned that measure the secondary changes in topological connections in various neurodegenerative diseases and injuries and upon therapeutic interventions in longitudinal studies.-
dc.languageengen_US
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012en_US
dc.titleDifferentiation of primary and secondary degeneration in the visual pathway using in vivo Mn-enhanced MRIen_US
dc.typeConference_Paperen_US
dc.identifier.emailLi, J: lijiang@fmmu.edu.cnen_US
dc.identifier.emailZhou, IY: iriszhou@eee.hku.hk-
dc.identifier.emailKau, P: kwflui@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros207483en_US
dc.publisher.placeAustralia-
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In proceedings of the 20th ISMRM, 2012, no. 0949-

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