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Conference Paper: Differentiation of primary and secondary degeneration in the visual pathway using in vivo Mn-enhanced MRI
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TitleDifferentiation of primary and secondary degeneration in the visual pathway using in vivo Mn-enhanced MRI
 
AuthorsChan, KC
Li, J
Zhou, IY
Kau, P
So, KF
Wu, EX
 
Issue Date2012
 
PublisherInternational Society of Magnetic Resonance in Medicine.
 
CitationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In proceedings of the 20th ISMRM, 2012, no. 0949 [How to Cite?]
 
AbstractThis study explores the capability of high-resolution Mn-enhanced MRI (MEMRI) for in vivo, longitudinal evaluation of primary and secondary degeneration along the retinocollicular projections after partial transection of right superior optic nerve in rats. At 1 week and 6 weeks after partial optic nerve injury, a consistent T1W hypointensity by about 28% was observed in the left lateral superior colliculus (SC) relative to the contralateral hemisphere, reflective of primary loss of topological connections and Mn2+ transport in the retinocollicular projections. The left medial SC had a reduced T1W signal intensity by 11% compared to the right medial SC at Week 1. Such reduction further increased to 16% at Week 6, indicative of secondary loss of retinal ganglion cells and axons projecting through the uninjured, inferior optic nerve. The results of this study demonstrated the feasibility of in vivo, high-resolution MEMRI for assessing the primary and secondary degeneration topologically and longitudinally along the visual pathway. Future MEMRI studies are envisioned that measure the secondary changes in topological connections in various neurodegenerative diseases and injuries and upon therapeutic interventions in longitudinal studies.
 
DescriptionTheme: Adapting MR in a Changing World
Traditional Poster Session - Neuro B: Manganese Enhanced MRI (MEMRI): no. 0949
 
DC FieldValue
dc.contributor.authorChan, KC
 
dc.contributor.authorLi, J
 
dc.contributor.authorZhou, IY
 
dc.contributor.authorKau, P
 
dc.contributor.authorSo, KF
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2012-09-20T08:16:11Z
 
dc.date.available2012-09-20T08:16:11Z
 
dc.date.issued2012
 
dc.description.abstractThis study explores the capability of high-resolution Mn-enhanced MRI (MEMRI) for in vivo, longitudinal evaluation of primary and secondary degeneration along the retinocollicular projections after partial transection of right superior optic nerve in rats. At 1 week and 6 weeks after partial optic nerve injury, a consistent T1W hypointensity by about 28% was observed in the left lateral superior colliculus (SC) relative to the contralateral hemisphere, reflective of primary loss of topological connections and Mn2+ transport in the retinocollicular projections. The left medial SC had a reduced T1W signal intensity by 11% compared to the right medial SC at Week 1. Such reduction further increased to 16% at Week 6, indicative of secondary loss of retinal ganglion cells and axons projecting through the uninjured, inferior optic nerve. The results of this study demonstrated the feasibility of in vivo, high-resolution MEMRI for assessing the primary and secondary degeneration topologically and longitudinally along the visual pathway. Future MEMRI studies are envisioned that measure the secondary changes in topological connections in various neurodegenerative diseases and injuries and upon therapeutic interventions in longitudinal studies.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionTheme: Adapting MR in a Changing World
 
dc.descriptionTraditional Poster Session - Neuro B: Manganese Enhanced MRI (MEMRI): no. 0949
 
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In proceedings of the 20th ISMRM, 2012, no. 0949
 
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In proceedings of the 20th ISMRM, 2012, no. 0949 [How to Cite?]
 
dc.identifier.hkuros207483
 
dc.identifier.urihttp://hdl.handle.net/10722/165194
 
dc.languageeng
 
dc.publisherInternational Society of Magnetic Resonance in Medicine.
 
dc.publisher.placeAustralia
 
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012
 
dc.titleDifferentiation of primary and secondary degeneration in the visual pathway using in vivo Mn-enhanced MRI
 
dc.typeConference_Paper
 
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<item><contributor.author>Chan, KC</contributor.author>
<contributor.author>Li, J</contributor.author>
<contributor.author>Zhou, IY</contributor.author>
<contributor.author>Kau, P</contributor.author>
<contributor.author>So, KF</contributor.author>
<contributor.author>Wu, EX</contributor.author>
<date.accessioned>2012-09-20T08:16:11Z</date.accessioned>
<date.available>2012-09-20T08:16:11Z</date.available>
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<description.abstract>This study explores the capability of high-resolution Mn-enhanced MRI (MEMRI) for in vivo, longitudinal evaluation of primary and secondary degeneration along the retinocollicular projections after partial transection of right superior optic nerve in rats. At 1 week and 6 weeks after partial optic nerve injury, a consistent T1W hypointensity by about 28% was observed in the left lateral superior colliculus (SC) relative to the contralateral hemisphere, reflective of primary loss of topological connections and Mn2+ transport in the retinocollicular projections. The left medial SC had a reduced T1W signal intensity by 11% compared to the right medial SC at Week 1. Such reduction further increased to 16% at Week 6, indicative of secondary loss of retinal ganglion cells and axons projecting through the uninjured, inferior optic nerve. The results of this study demonstrated the feasibility of in vivo, high-resolution MEMRI for assessing the primary and secondary degeneration topologically and longitudinally along the visual pathway. Future MEMRI studies are envisioned that measure the secondary changes in topological connections in various neurodegenerative diseases and injuries and upon therapeutic interventions in longitudinal studies.</description.abstract>
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