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Conference Paper: The variation of white matter tract in neonates with mild hypoxic-ischemic injury:a diffusion tensor image analysis by tract-based spatial statistics (TBSS)

TitleThe variation of white matter tract in neonates with mild hypoxic-ischemic injury:a diffusion tensor image analysis by tract-based spatial statistics (TBSS)
Authors
Issue Date2012
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0251 How to Cite?
Abstract
The aim of this study is to use tract-based spatial statistics (TBSS) to test the voxel-wise differences in fractional anisotropy (FA), 1, 2, 3 between normal and mild hypoxic-ischemic (HI) neonatal brains. 41 full term neonates (17 neonates with mild HI injury, 24 neonates as normal control,) and 31 preterm neonates (11 neonates with mild HI injury, 20 neonates as normal control) underwent T1 weighted images (T1WIs), T2 weighted images (T2WIs) and diffusion tensor image (DTI) within 28 days after birth. The results of TBSS mainly showed significantly decreased FA and increased 2, 3 in multiple white matter tracts (p<0.05). These differences of DTI indexes between the mild HI and normal neonates were mainly located in cerebral peduncle (CP), posterior limb of internal capsule (PLIC) and corona radiata (CR) both in full term and preterm groups. Moreover, the additional regions with above changes of DTI indexes in full term neonates were exhibited in external capsule (EC) and splenium of the corpus callosum (SCC) mainly. This is the first study to explore white matter injury in both preterm and term neonatal brains with mild HI injury by using TBSS for DTI data analyzing. TBSS, as an objective and sensitive method, can reveal multiple white matter microstructural abnormalities in mild HI neonatal brains.
DescriptionTheme: Adapting MR in a Changing World
Persistent Identifierhttp://hdl.handle.net/10722/165190

 

DC FieldValueLanguage
dc.contributor.authorGao, Jen_US
dc.contributor.authorLi, Xen_US
dc.contributor.authorHou, Xen_US
dc.contributor.authorSun, Qen_US
dc.contributor.authorYu, Ben_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorWan, Men_US
dc.contributor.authorYang, Jen_US
dc.date.accessioned2012-09-20T08:16:09Z-
dc.date.available2012-09-20T08:16:09Z-
dc.date.issued2012en_US
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0251en_US
dc.identifier.urihttp://hdl.handle.net/10722/165190-
dc.descriptionTheme: Adapting MR in a Changing World-
dc.descriptionOral Presentation - Session 25: Advanced Imaging of Prenatal/Neonatal Brain Injury: no. 0251-
dc.description.abstractThe aim of this study is to use tract-based spatial statistics (TBSS) to test the voxel-wise differences in fractional anisotropy (FA), 1, 2, 3 between normal and mild hypoxic-ischemic (HI) neonatal brains. 41 full term neonates (17 neonates with mild HI injury, 24 neonates as normal control,) and 31 preterm neonates (11 neonates with mild HI injury, 20 neonates as normal control) underwent T1 weighted images (T1WIs), T2 weighted images (T2WIs) and diffusion tensor image (DTI) within 28 days after birth. The results of TBSS mainly showed significantly decreased FA and increased 2, 3 in multiple white matter tracts (p<0.05). These differences of DTI indexes between the mild HI and normal neonates were mainly located in cerebral peduncle (CP), posterior limb of internal capsule (PLIC) and corona radiata (CR) both in full term and preterm groups. Moreover, the additional regions with above changes of DTI indexes in full term neonates were exhibited in external capsule (EC) and splenium of the corpus callosum (SCC) mainly. This is the first study to explore white matter injury in both preterm and term neonatal brains with mild HI injury by using TBSS for DTI data analyzing. TBSS, as an objective and sensitive method, can reveal multiple white matter microstructural abnormalities in mild HI neonatal brains.-
dc.languageengen_US
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012en_US
dc.titleThe variation of white matter tract in neonates with mild hypoxic-ischemic injury:a diffusion tensor image analysis by tract-based spatial statistics (TBSS)en_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX: ewu@eee.hku.hken_US
dc.identifier.emailYang, J: yj1118@hkucc.hku.hk-
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros207476en_US
dc.publisher.placeAustralia-
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0251-

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