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Conference Paper: The variation of white matter tract in neonates with mild hypoxic-ischemic injury:a diffusion tensor image analysis by tract-based spatial statistics (TBSS)
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TitleThe variation of white matter tract in neonates with mild hypoxic-ischemic injury:a diffusion tensor image analysis by tract-based spatial statistics (TBSS)
 
AuthorsGao, J
Li, X
Hou, X
Sun, Q
Yu, B
Wu, EX
Wan, M
Yang, J
 
Issue Date2012
 
PublisherInternational Society of Magnetic Resonance in Medicine.
 
CitationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0251 [How to Cite?]
 
AbstractThe aim of this study is to use tract-based spatial statistics (TBSS) to test the voxel-wise differences in fractional anisotropy (FA), 1, 2, 3 between normal and mild hypoxic-ischemic (HI) neonatal brains. 41 full term neonates (17 neonates with mild HI injury, 24 neonates as normal control,) and 31 preterm neonates (11 neonates with mild HI injury, 20 neonates as normal control) underwent T1 weighted images (T1WIs), T2 weighted images (T2WIs) and diffusion tensor image (DTI) within 28 days after birth. The results of TBSS mainly showed significantly decreased FA and increased 2, 3 in multiple white matter tracts (p<0.05). These differences of DTI indexes between the mild HI and normal neonates were mainly located in cerebral peduncle (CP), posterior limb of internal capsule (PLIC) and corona radiata (CR) both in full term and preterm groups. Moreover, the additional regions with above changes of DTI indexes in full term neonates were exhibited in external capsule (EC) and splenium of the corpus callosum (SCC) mainly. This is the first study to explore white matter injury in both preterm and term neonatal brains with mild HI injury by using TBSS for DTI data analyzing. TBSS, as an objective and sensitive method, can reveal multiple white matter microstructural abnormalities in mild HI neonatal brains.
 
DescriptionTheme: Adapting MR in a Changing World
Oral Presentation - Session 25: Advanced Imaging of Prenatal/Neonatal Brain Injury: no. 0251
 
DC FieldValue
dc.contributor.authorGao, J
 
dc.contributor.authorLi, X
 
dc.contributor.authorHou, X
 
dc.contributor.authorSun, Q
 
dc.contributor.authorYu, B
 
dc.contributor.authorWu, EX
 
dc.contributor.authorWan, M
 
dc.contributor.authorYang, J
 
dc.date.accessioned2012-09-20T08:16:09Z
 
dc.date.available2012-09-20T08:16:09Z
 
dc.date.issued2012
 
dc.description.abstractThe aim of this study is to use tract-based spatial statistics (TBSS) to test the voxel-wise differences in fractional anisotropy (FA), 1, 2, 3 between normal and mild hypoxic-ischemic (HI) neonatal brains. 41 full term neonates (17 neonates with mild HI injury, 24 neonates as normal control,) and 31 preterm neonates (11 neonates with mild HI injury, 20 neonates as normal control) underwent T1 weighted images (T1WIs), T2 weighted images (T2WIs) and diffusion tensor image (DTI) within 28 days after birth. The results of TBSS mainly showed significantly decreased FA and increased 2, 3 in multiple white matter tracts (p<0.05). These differences of DTI indexes between the mild HI and normal neonates were mainly located in cerebral peduncle (CP), posterior limb of internal capsule (PLIC) and corona radiata (CR) both in full term and preterm groups. Moreover, the additional regions with above changes of DTI indexes in full term neonates were exhibited in external capsule (EC) and splenium of the corpus callosum (SCC) mainly. This is the first study to explore white matter injury in both preterm and term neonatal brains with mild HI injury by using TBSS for DTI data analyzing. TBSS, as an objective and sensitive method, can reveal multiple white matter microstructural abnormalities in mild HI neonatal brains.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionTheme: Adapting MR in a Changing World
 
dc.descriptionOral Presentation - Session 25: Advanced Imaging of Prenatal/Neonatal Brain Injury: no. 0251
 
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0251
 
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 0251 [How to Cite?]
 
dc.identifier.hkuros207476
 
dc.identifier.urihttp://hdl.handle.net/10722/165190
 
dc.languageeng
 
dc.publisherInternational Society of Magnetic Resonance in Medicine.
 
dc.publisher.placeAustralia
 
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012
 
dc.titleThe variation of white matter tract in neonates with mild hypoxic-ischemic injury:a diffusion tensor image analysis by tract-based spatial statistics (TBSS)
 
dc.typeConference_Paper
 
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<contributor.author>Li, X</contributor.author>
<contributor.author>Hou, X</contributor.author>
<contributor.author>Sun, Q</contributor.author>
<contributor.author>Yu, B</contributor.author>
<contributor.author>Wu, EX</contributor.author>
<contributor.author>Wan, M</contributor.author>
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