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Conference Paper: Metabolic changes in hippocampus and thalamus after sleep deprivation: an experimental proton MRS study

TitleMetabolic changes in hippocampus and thalamus after sleep deprivation: an experimental proton MRS study
Authors
Zhou, IYDing, AYLee, FYHWu, EX
Issue Date2012
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3093 How to Cite?
AbstractIn this study, in vivo 1H MRS was employed to investigate the metabolic changes induced by sleep deprivation (SD) in hippocampus and thalamus of a rat model. Reduced NAA:Cr was found in hippocampus, indicating neuronal loss and cellular dysfunction. The reduction of glutamate observed in hippocampus can reflect reduced cellular excitability. In thalamus, lactate was found to decrease in thalamus after SD, as a result of glucose metabolism decrease. Our finding of Glu:Cr increase in thalamus possibly arises from increased glutamine synthetase. The results of this study provide neurochemical evidence of the behavioral deficits associated with sleep deprivation.
DescriptionTheme: Adapting MR in a Changing World
Electronic Poster Session - Neuro A - Animal Models of Brain Disease & Neurovascular: no. 3093 (computer no. 12)
Persistent Identifierhttp://hdl.handle.net/10722/165187

 

DC FieldValueLanguage
dc.contributor.authorZhou, IYen_US
dc.contributor.authorDing, AYen_US
dc.contributor.authorLee, FYHen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2012-09-20T08:16:07Z-
dc.date.available2012-09-20T08:16:07Z-
dc.date.issued2012en_US
dc.identifier.citationThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3093en_US
dc.identifier.urihttp://hdl.handle.net/10722/165187-
dc.descriptionTheme: Adapting MR in a Changing World-
dc.descriptionElectronic Poster Session - Neuro A - Animal Models of Brain Disease & Neurovascular: no. 3093 (computer no. 12)-
dc.description.abstractIn this study, in vivo 1H MRS was employed to investigate the metabolic changes induced by sleep deprivation (SD) in hippocampus and thalamus of a rat model. Reduced NAA:Cr was found in hippocampus, indicating neuronal loss and cellular dysfunction. The reduction of glutamate observed in hippocampus can reflect reduced cellular excitability. In thalamus, lactate was found to decrease in thalamus after SD, as a result of glucose metabolism decrease. Our finding of Glu:Cr increase in thalamus possibly arises from increased glutamine synthetase. The results of this study provide neurochemical evidence of the behavioral deficits associated with sleep deprivation.-
dc.languageengen_US
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine, ISMRM 2012en_US
dc.titleMetabolic changes in hippocampus and thalamus after sleep deprivation: an experimental proton MRS studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailZhou, IY: iriszhou@eee.hku.hken_US
dc.identifier.emailLee, FYH: frankyhlee@gmail.com-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros207307en_US
dc.publisher.placeAustralia-
dc.description.otherThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of the 20th ISMRM, 2012, no. 3093-

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