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Article: Role of label-retaining cells in estrogen-induced endometrial regeneration

TitleRole of label-retaining cells in estrogen-induced endometrial regeneration
Authors
Issue Date2012
PublisherSage Publications, Inc. The Journal's web site is located at http://rsx.sagepub.com
Citation
Reproductive Sciences, 2012, v. 19 n. 1, p. 102-114 How to Cite?
AbstractCandidate stem/progenitor cells have been identified in mouse endometrium as label-retaining cells (LRCs). The role of endometrial stem/progenitor cells in initiating estrogen-stimulated endometrial growth in prepubertal and cycling mice was investigated following a single 17beta-estradiol (E2) injection in bromodeoxyuridine (BrdU)-labeled and -chased (LRC), ovariectomised mice. Proliferating (BrdU(+)/Ki-67(+)) and mitotic (BrdU(+)/PH3(+)) epithelial LRCs were first detected in prepubertal mice 8 hours following E2 treatment, initiating the proliferative response. In contrast, all epithelial LRCs and 16% of epithelial cells in cycling mice proliferated within 2 hours. In cycling mice, 12% of stromal LRCs initiated a proliferative response 8 hours after E2. Proliferating epithelial LRCs and most stromal LRCs (85%) lacked estrogen receptor-alpha (ESR1). These findings suggest that endometrial epithelial LRCs function as stem/progenitor cells by receiving proliferative signals from neighboring ESR1(+) niche cells to initiate the growth of the epithelium during development, while mature epithelial cells may undergo self-replication in cycling endometrium.
Persistent Identifierhttp://hdl.handle.net/10722/164809
ISSN
2014 Impact Factor: 2.230
2014 SCImago Journal Rankings: 0.820
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, RWSen_US
dc.contributor.authorKaitu'u-Lino, Ten_US
dc.contributor.authorGargett, CEen_US
dc.date.accessioned2012-09-20T08:10:04Z-
dc.date.available2012-09-20T08:10:04Z-
dc.date.issued2012en_US
dc.identifier.citationReproductive Sciences, 2012, v. 19 n. 1, p. 102-114en_US
dc.identifier.issn1933-7191-
dc.identifier.urihttp://hdl.handle.net/10722/164809-
dc.description.abstractCandidate stem/progenitor cells have been identified in mouse endometrium as label-retaining cells (LRCs). The role of endometrial stem/progenitor cells in initiating estrogen-stimulated endometrial growth in prepubertal and cycling mice was investigated following a single 17beta-estradiol (E2) injection in bromodeoxyuridine (BrdU)-labeled and -chased (LRC), ovariectomised mice. Proliferating (BrdU(+)/Ki-67(+)) and mitotic (BrdU(+)/PH3(+)) epithelial LRCs were first detected in prepubertal mice 8 hours following E2 treatment, initiating the proliferative response. In contrast, all epithelial LRCs and 16% of epithelial cells in cycling mice proliferated within 2 hours. In cycling mice, 12% of stromal LRCs initiated a proliferative response 8 hours after E2. Proliferating epithelial LRCs and most stromal LRCs (85%) lacked estrogen receptor-alpha (ESR1). These findings suggest that endometrial epithelial LRCs function as stem/progenitor cells by receiving proliferative signals from neighboring ESR1(+) niche cells to initiate the growth of the epithelium during development, while mature epithelial cells may undergo self-replication in cycling endometrium.-
dc.languageengen_US
dc.publisherSage Publications, Inc. The Journal's web site is located at http://rsx.sagepub.com-
dc.relation.ispartofReproductive Sciencesen_US
dc.rightsReproductive Sciences. Copyright © Sage Publications, Inc.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCell Proliferation - drug effects-
dc.subject.meshEndometrium - cytology - drug effects-
dc.subject.meshEstrogens - pharmacology-
dc.subject.meshRegeneration - drug effects-
dc.subject.meshStem Cells - drug effects-
dc.titleRole of label-retaining cells in estrogen-induced endometrial regenerationen_US
dc.typeArticleen_US
dc.identifier.emailChan, RWS: rwschan@hku.hken_US
dc.identifier.emailGargett, CE: caroline.gargett@monash.edu-
dc.description.naturepostprint-
dc.identifier.doi10.1177/1933719111414207-
dc.identifier.pmid22064386-
dc.identifier.scopuseid_2-s2.0-84855501315-
dc.identifier.hkuros206846en_US
dc.identifier.volume19en_US
dc.identifier.issue1-
dc.identifier.spage102en_US
dc.identifier.epage114en_US
dc.identifier.isiWOS:000298855000012-
dc.publisher.placeUnited States-
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