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Article: Adjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescripton study (2001-2008)

TitleAdjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescripton study (2001-2008)
Authors
Issue Date2011
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PNP
Citation
International Journal of Neuropsychopharmacology, 2011, v. 14 n. 9, p. 1157-1164 How to Cite?
AbstractRecent studies indicate relatively high international rates of adjunctive psychotropic medication, including mood stabilizers, for patients with schizophrenia. Since such treatments are little studied in Asia, we examined the frequency of mood-stabilizer use and its clinical correlates among hospitalized Asian patients diagnosed with schizophrenia in 2001-2008. We evaluated usage rates of mood stabilizers with antipsychotic drugs, and associated factors, for in-patients diagnosed with DSM-IV schizophrenia in 2001, 2004 and 2008 in nine Asian regions: China, Hong Kong, India, Korea, Japan, Malaysia, Taiwan, Thailand, and Singapore. Overall, mood stabilizers were given to 20.4% (n=1377/6761) of hospitalized schizophrenia patients, with increased usage over time. Mood-stabilizer use was significantly and independently associated in multivariate logistic modeling with: aggressive behaviour, disorganized speech, year sampled (2008 vs. earlier), multiple hospitalizations, less negative symptoms, younger age, with regional variation (Japan, Hong Kong, Singapore>Taiwan or China). Co-prescription of adjunctive mood stabilizers with antipsychotics for hospitalized Asian schizophrenia patients increased over the past decade, and was associated with specific clinical characteristics. This practice parallels findings in other countries and illustrates ongoing tension between evidence-based practice vs. individualized, empirical treatment of psychotic disorders.
Persistent Identifierhttp://hdl.handle.net/10722/164561
ISSN
2015 Impact Factor: 4.333
2015 SCImago Journal Rankings: 1.690
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSim, Ken_US
dc.contributor.authorYong, KHen_US
dc.contributor.authorChan, YHen_US
dc.contributor.authorTor, PCen_US
dc.contributor.authorXiang, YTen_US
dc.contributor.authorWang, CYen_US
dc.contributor.authorLee, EHMen_US
dc.contributor.authorFujii, Sen_US
dc.contributor.authorYang, SYen_US
dc.contributor.authorChong, MYen_US
dc.contributor.authorUngvari, GSen_US
dc.contributor.authorSi, Ten_US
dc.contributor.authorHe, YLen_US
dc.contributor.authorChung, EKen_US
dc.contributor.authorChee, KYen_US
dc.contributor.authorTrivedi, Jen_US
dc.contributor.authorUdomratn, Pen_US
dc.contributor.authorShinfuku, Nen_US
dc.contributor.authorKua, EHen_US
dc.contributor.authorTan, CHen_US
dc.contributor.authorSartorius, Nen_US
dc.contributor.authorBaldessarini, RJen_US
dc.date.accessioned2012-09-20T08:06:00Z-
dc.date.available2012-09-20T08:06:00Z-
dc.date.issued2011en_US
dc.identifier.citationInternational Journal of Neuropsychopharmacology, 2011, v. 14 n. 9, p. 1157-1164en_US
dc.identifier.issn1461-1457-
dc.identifier.urihttp://hdl.handle.net/10722/164561-
dc.description.abstractRecent studies indicate relatively high international rates of adjunctive psychotropic medication, including mood stabilizers, for patients with schizophrenia. Since such treatments are little studied in Asia, we examined the frequency of mood-stabilizer use and its clinical correlates among hospitalized Asian patients diagnosed with schizophrenia in 2001-2008. We evaluated usage rates of mood stabilizers with antipsychotic drugs, and associated factors, for in-patients diagnosed with DSM-IV schizophrenia in 2001, 2004 and 2008 in nine Asian regions: China, Hong Kong, India, Korea, Japan, Malaysia, Taiwan, Thailand, and Singapore. Overall, mood stabilizers were given to 20.4% (n=1377/6761) of hospitalized schizophrenia patients, with increased usage over time. Mood-stabilizer use was significantly and independently associated in multivariate logistic modeling with: aggressive behaviour, disorganized speech, year sampled (2008 vs. earlier), multiple hospitalizations, less negative symptoms, younger age, with regional variation (Japan, Hong Kong, Singapore>Taiwan or China). Co-prescription of adjunctive mood stabilizers with antipsychotics for hospitalized Asian schizophrenia patients increased over the past decade, and was associated with specific clinical characteristics. This practice parallels findings in other countries and illustrates ongoing tension between evidence-based practice vs. individualized, empirical treatment of psychotic disorders.-
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PNP-
dc.relation.ispartofInternational Journal of Neuropsychopharmacologyen_US
dc.rightsInternational Journal of Neuropsychopharmacology. Copyright © Cambridge University Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAntimanic Agents - administration and dosage - therapeutic use-
dc.subject.meshAntipsychotic Agents - administration and dosage - therapeutic use-
dc.subject.meshPhysician's Practice Patterns - trends-
dc.subject.meshSchizophrenia - drug therapy - physiopathology-
dc.subject.meshDiagnostic and Statistical Manual of Mental Disorders-
dc.titleAdjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescripton study (2001-2008)en_US
dc.typeArticleen_US
dc.identifier.emailLee, EHM: edwinlhm@hku.hken_US
dc.identifier.authorityLee, EHM=rp01575en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1017/S1461145711000563-
dc.identifier.pmid21557883-
dc.identifier.scopuseid_2-s2.0-84863011026-
dc.identifier.hkuros206328en_US
dc.identifier.volume14en_US
dc.identifier.issue9en_US
dc.identifier.spage1157en_US
dc.identifier.epage1164en_US
dc.identifier.isiWOS:000295434600002-
dc.publisher.placeUnited Kingdom-

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