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- Publisher Website: 10.1093/cvr/cvs182
- Scopus: eid_2-s2.0-84866952061
- PMID: 22652005
- WOS: WOS:000306685800005
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Article: Arterial endothelial cells: still the craftsmen of regenerated endothelium
Title | Arterial endothelial cells: still the craftsmen of regenerated endothelium |
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Authors | |
Keywords | Endothelial progenitor cells Endothelial cell Atherosclerosis Allograft vasculopathy Mechanical injury |
Issue Date | 2012 |
Publisher | Oxford University Press. The Journal's web site is located at http://cardiovascres.oxfordjournals.org |
Citation | Cardiovascular Research, 2012, v. 95 n. 3, p. 281-289 How to Cite? |
Abstract | For more than a decade, a prevailing hypothesis in research related to arterial disease has been that circulating endothelial progenitor cells (EPCs) provide protection by their innate ability to replace dysfunctional or damaged endothelium. This paradigm has led to extensive investigation of EPCs in the hope of finding therapeutic targets to control their homing and differentiation. However, from the very beginning, the nomenclature and the phenotype of EPCs have been subject to controversy and there are currently no specific markers that can unambiguously identify these cells. Moreover, many of the initial observations that EPCs differentiate to endothelial cells in the course of arterial disease have been criticized for methodological problems. The present review discusses the contrasting experimental evidence as to the role of EPCs in contributing to relining of the endothelium and highlights some of the methodological pitfalls and terminological ambiguities that confuse the field. |
Persistent Identifier | http://hdl.handle.net/10722/164492 |
ISSN | 2023 Impact Factor: 10.2 2023 SCImago Journal Rankings: 2.809 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Hagensen, MK | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Bentzon, JF | en_US |
dc.date.accessioned | 2012-09-20T08:00:21Z | - |
dc.date.available | 2012-09-20T08:00:21Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Cardiovascular Research, 2012, v. 95 n. 3, p. 281-289 | en_US |
dc.identifier.issn | 0008-6363 | - |
dc.identifier.uri | http://hdl.handle.net/10722/164492 | - |
dc.description.abstract | For more than a decade, a prevailing hypothesis in research related to arterial disease has been that circulating endothelial progenitor cells (EPCs) provide protection by their innate ability to replace dysfunctional or damaged endothelium. This paradigm has led to extensive investigation of EPCs in the hope of finding therapeutic targets to control their homing and differentiation. However, from the very beginning, the nomenclature and the phenotype of EPCs have been subject to controversy and there are currently no specific markers that can unambiguously identify these cells. Moreover, many of the initial observations that EPCs differentiate to endothelial cells in the course of arterial disease have been criticized for methodological problems. The present review discusses the contrasting experimental evidence as to the role of EPCs in contributing to relining of the endothelium and highlights some of the methodological pitfalls and terminological ambiguities that confuse the field. | - |
dc.language | eng | en_US |
dc.publisher | Oxford University Press. The Journal's web site is located at http://cardiovascres.oxfordjournals.org | - |
dc.relation.ispartof | Cardiovascular Research | en_US |
dc.rights | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Cardiovascular Research following peer review. The definitive publisher-authenticated version Cardiovascular Research, 2012, v. 95 n. 3, p. 281-289 is available online at: http://cardiovascres.oxfordjournals.org/content/95/3/281 | - |
dc.subject | Endothelial progenitor cells | - |
dc.subject | Endothelial cell | - |
dc.subject | Atherosclerosis | - |
dc.subject | Allograft vasculopathy | - |
dc.subject | Mechanical injury | - |
dc.title | Arterial endothelial cells: still the craftsmen of regenerated endothelium | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM: vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PMGR=rp00238 | en_US |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1093/cvr/cvs182 | - |
dc.identifier.pmid | 22652005 | - |
dc.identifier.scopus | eid_2-s2.0-84866952061 | - |
dc.identifier.hkuros | 210031 | en_US |
dc.identifier.volume | 95 | en_US |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 281 | en_US |
dc.identifier.epage | 289 | en_US |
dc.identifier.isi | WOS:000306685800005 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.citeulike | 11850530 | - |
dc.identifier.issnl | 0008-6363 | - |