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Article: Arterial endothelial cells: still the craftsmen of regenerated endothelium

TitleArterial endothelial cells: still the craftsmen of regenerated endothelium
Authors
KeywordsEndothelial progenitor cells
Endothelial cell
Atherosclerosis
Allograft vasculopathy
Mechanical injury
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://cardiovascres.oxfordjournals.org
Citation
Cardiovascular Research, 2012, v. 95 n. 3, p. 281-289 How to Cite?
AbstractFor more than a decade, a prevailing hypothesis in research related to arterial disease has been that circulating endothelial progenitor cells (EPCs) provide protection by their innate ability to replace dysfunctional or damaged endothelium. This paradigm has led to extensive investigation of EPCs in the hope of finding therapeutic targets to control their homing and differentiation. However, from the very beginning, the nomenclature and the phenotype of EPCs have been subject to controversy and there are currently no specific markers that can unambiguously identify these cells. Moreover, many of the initial observations that EPCs differentiate to endothelial cells in the course of arterial disease have been criticized for methodological problems. The present review discusses the contrasting experimental evidence as to the role of EPCs in contributing to relining of the endothelium and highlights some of the methodological pitfalls and terminological ambiguities that confuse the field.
Persistent Identifierhttp://hdl.handle.net/10722/164492
ISSN
2015 Impact Factor: 5.465
2015 SCImago Journal Rankings: 2.897
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHagensen, MKen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorBentzon, JFen_US
dc.date.accessioned2012-09-20T08:00:21Z-
dc.date.available2012-09-20T08:00:21Z-
dc.date.issued2012en_US
dc.identifier.citationCardiovascular Research, 2012, v. 95 n. 3, p. 281-289en_US
dc.identifier.issn0008-6363-
dc.identifier.urihttp://hdl.handle.net/10722/164492-
dc.description.abstractFor more than a decade, a prevailing hypothesis in research related to arterial disease has been that circulating endothelial progenitor cells (EPCs) provide protection by their innate ability to replace dysfunctional or damaged endothelium. This paradigm has led to extensive investigation of EPCs in the hope of finding therapeutic targets to control their homing and differentiation. However, from the very beginning, the nomenclature and the phenotype of EPCs have been subject to controversy and there are currently no specific markers that can unambiguously identify these cells. Moreover, many of the initial observations that EPCs differentiate to endothelial cells in the course of arterial disease have been criticized for methodological problems. The present review discusses the contrasting experimental evidence as to the role of EPCs in contributing to relining of the endothelium and highlights some of the methodological pitfalls and terminological ambiguities that confuse the field.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://cardiovascres.oxfordjournals.org-
dc.relation.ispartofCardiovascular Researchen_US
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Cardiovascular Research following peer review. The definitive publisher-authenticated version Cardiovascular Research, 2012, v. 95 n. 3, p. 281-289 is available online at: http://cardiovascres.oxfordjournals.org/content/95/3/281-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectEndothelial progenitor cells-
dc.subjectEndothelial cell-
dc.subjectAtherosclerosis-
dc.subjectAllograft vasculopathy-
dc.subjectMechanical injury-
dc.titleArterial endothelial cells: still the craftsmen of regenerated endotheliumen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PMGR=rp00238en_US
dc.description.naturepostprint-
dc.identifier.doi10.1093/cvr/cvs182-
dc.identifier.pmid22652005-
dc.identifier.hkuros210031en_US
dc.identifier.volume95en_US
dc.identifier.issue3-
dc.identifier.spage281en_US
dc.identifier.epage289en_US
dc.identifier.isiWOS:000306685800005-
dc.publisher.placeUnited Kingdom-
dc.identifier.citeulike11850530-

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