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Article: Prevalence and extent of subclinical atherosclerosis in patients with psoriasis

TitlePrevalence and extent of subclinical atherosclerosis in patients with psoriasis
Authors
Issue Date2013
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0954-6820
Citation
Journal of Internal Medicine: from genes and molecules to patients, 2013, v. 273 n. 3, p. 273-282 How to Cite?
AbstractOBJECTIVE: Patients with psoriasis are prone to premature atherosclerosis and increased risk of cardiovascular disease events. However, the prevalence and extent of atherosclerosis in patients with psoriasis are unknown. DESIGN: A cross-sectional study. SETTING AND SUBJECTS: The prevalence and extent of coronary and carotid atherosclerosis were compared in 70 patients with psoriasis (46 +/- 9 years, 71% male) without known cardiovascular disease or joint involvement and 51 age- and gender-matched healthy control subjects (45 +/- 7 years, 71% male). Systemic inflammation was assessed by the level of high-sensitivity C-reactive protein (hs-CRP). Coronary atherosclerosis was determined by the coronary calcification score (CCS) measured by multi-detector computed tomography. Carotid atherosclerosis was assessed by high-resolution ultrasound-derived carotid intima-media thickness (cIMT). RESULTS: Patients with psoriasis had a higher prevalence of coronary atherosclerosis (CCS > 0; 28.6% vs. 3.9%, P < 0.01), and a higher degree of coronary atherosclerosis estimated by the mean CCS (67.4 +/- 349.2 vs. 0.5 +/- 3.0, P < 0.05) compared with controls. Similarly, cIMT was significantly greater in patients with psoriasis than in control subjects (0.73 +/- 0.11 mm vs. 0.67 +/- 0.08 mm, P < 0.01). Multiple logistic regression revealed that psoriasis [odd ratio (OR): 10.54, 95% confidence interval (CI) 1.89-58.67, P < 0.01] and serum total cholesterol level (OR 2.10, 95% CI 1.01-4.37) were associated with the presence of coronary atherosclerosis (CCS > 0). By contrast, only age was independently associated with increased cIMT. Amongst participants with no traditional cardiovascular disease risk factors, hs-CRP level was higher in patients with psoriasis than in controls. CONCLUSION: The present results demonstrate early-onset, diffuse arterial atherosclerosis in coronary and carotid arteries in patients with psoriasis, but not in age- and gender-matched control subjects. Low-grade inflammation could explain the presence of premature atherosclerosis in patients with psoriasis.
Persistent Identifierhttp://hdl.handle.net/10722/164272
ISSN
2015 Impact Factor: 7.803
2015 SCImago Journal Rankings: 3.315
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYiu, KHen_US
dc.contributor.authorYeung, CKen_US
dc.contributor.authorZhao, CTen_US
dc.contributor.authorChan, JCYen_US
dc.contributor.authorSiu, DCWen_US
dc.contributor.authorTam, Sen_US
dc.contributor.authorWong, CSen_US
dc.contributor.authorYan, GHen_US
dc.contributor.authorYue, WSen_US
dc.contributor.authorKhong, PLen_US
dc.contributor.authorChan, HHen_US
dc.contributor.authorTse, HFen_US
dc.date.accessioned2012-09-20T07:57:30Z-
dc.date.available2012-09-20T07:57:30Z-
dc.date.issued2013en_US
dc.identifier.citationJournal of Internal Medicine: from genes and molecules to patients, 2013, v. 273 n. 3, p. 273-282en_US
dc.identifier.issn0954-6820-
dc.identifier.urihttp://hdl.handle.net/10722/164272-
dc.description.abstractOBJECTIVE: Patients with psoriasis are prone to premature atherosclerosis and increased risk of cardiovascular disease events. However, the prevalence and extent of atherosclerosis in patients with psoriasis are unknown. DESIGN: A cross-sectional study. SETTING AND SUBJECTS: The prevalence and extent of coronary and carotid atherosclerosis were compared in 70 patients with psoriasis (46 +/- 9 years, 71% male) without known cardiovascular disease or joint involvement and 51 age- and gender-matched healthy control subjects (45 +/- 7 years, 71% male). Systemic inflammation was assessed by the level of high-sensitivity C-reactive protein (hs-CRP). Coronary atherosclerosis was determined by the coronary calcification score (CCS) measured by multi-detector computed tomography. Carotid atherosclerosis was assessed by high-resolution ultrasound-derived carotid intima-media thickness (cIMT). RESULTS: Patients with psoriasis had a higher prevalence of coronary atherosclerosis (CCS > 0; 28.6% vs. 3.9%, P < 0.01), and a higher degree of coronary atherosclerosis estimated by the mean CCS (67.4 +/- 349.2 vs. 0.5 +/- 3.0, P < 0.05) compared with controls. Similarly, cIMT was significantly greater in patients with psoriasis than in control subjects (0.73 +/- 0.11 mm vs. 0.67 +/- 0.08 mm, P < 0.01). Multiple logistic regression revealed that psoriasis [odd ratio (OR): 10.54, 95% confidence interval (CI) 1.89-58.67, P < 0.01] and serum total cholesterol level (OR 2.10, 95% CI 1.01-4.37) were associated with the presence of coronary atherosclerosis (CCS > 0). By contrast, only age was independently associated with increased cIMT. Amongst participants with no traditional cardiovascular disease risk factors, hs-CRP level was higher in patients with psoriasis than in controls. CONCLUSION: The present results demonstrate early-onset, diffuse arterial atherosclerosis in coronary and carotid arteries in patients with psoriasis, but not in age- and gender-matched control subjects. Low-grade inflammation could explain the presence of premature atherosclerosis in patients with psoriasis.-
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0954-6820-
dc.relation.ispartofJournal of Internal Medicine: from genes and molecules to patientsen_US
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subject.meshCarotid Artery Diseases - epidemiology - ultrasonography-
dc.subject.meshCoronary Artery Disease - epidemiology - radiography-
dc.subject.meshCross-Sectional Studies-
dc.subject.meshMultidetector Computed Tomography-
dc.subject.meshPsoriasis - epidemiology-
dc.titlePrevalence and extent of subclinical atherosclerosis in patients with psoriasisen_US
dc.typeArticleen_US
dc.identifier.emailYiu, KH: khkyiu@hku.hken_US
dc.identifier.emailYeung, CK: drcyeung@hku.hken_US
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hken_US
dc.identifier.emailWong, CS: drcswong@hku.hken_US
dc.identifier.emailYan, GH: guohui@hkucc.hku.hk-
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.authorityYiu, KH=rp01490en_US
dc.identifier.authorityChan, JCY=rp01737en_US
dc.identifier.authoritySiu, DCW=rp00534en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/joim.12002-
dc.identifier.pmid23003220-
dc.identifier.scopuseid_2-s2.0-84873991348-
dc.identifier.hkuros214839-
dc.identifier.hkuros237595-
dc.identifier.volume273-
dc.identifier.issue3-
dc.identifier.spage273-
dc.identifier.epage282-
dc.identifier.isiWOS:000315098100007-
dc.publisher.placeUnited Kingdom-

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