Article: White matter development in adolescence: diffusion tensor imaging and meta-analytic results

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TitleWhite matter development in adolescence: diffusion tensor imaging and meta-analytic results
AuthorsPeters, BD4 7
Szeszko, PR4 7
Radua, J1 2
Ikuta, T4 7
Gruner, P4 7
DeRosse, P4 7
Zhang, JP4 7
Giorgio, A10 11
Qiu, D3 5
Tapert, SF9
Brauer, J6
Asato, MR8
Khong, PL5
James, AC11
Gallego, JA4 7
Malhotra, AK4 7
KeywordsControlled study
Diffusion tensor imaging
Medial longitudinal fasciculus
Meta analysis (topic)
Normal human
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
CitationSchizophrenia Bulletin, 2012, v. 38 n. 6, p. 1308-1317 [How to Cite?]
DOI: http://dx.doi.org/10.1093/schbul/sbs054
AbstractBackground In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fractional anisotropy (FA), a putative measure of WM integrity, from childhood into adolescence. However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence. Methods DTI was performed in 78 healthy subjects aged 8-21 years, and voxel-wise analysis conducted using tract-based spatial statistics (TBSS). In addition, we performed the first meta-analysis of TBSS studies on WM development in adolescence. Results In our sample, we observed bilateral increases in FA with age, which were most significant in the left superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and anterior thalamic radiation. These findings were confirmed by the meta-analysis, and FA increase in the bilateral SLF was the most consistent finding across studies. Moreover, in our sample, FA of the bilateral SLF showed a positive association with verbal working memory performance and partially mediated increases in verbal fluency as a function of increasing age. Conclusions These data highlight increasing connectivity in the SLF during adolescence. In light of evidence for compromised SLF integrity in high-risk and first-episode patients, these data suggest that abnormal maturation of the SLF during adolescence may be a key target in the neurodevelopment of schizophrenia.
ISSN0586-7614
2011 Impact Factor: 8.8
2011 SCImago Journal Rankings: 0.444
DOIhttp://dx.doi.org/10.1093/schbul/sbs054
PubMed Central IDPMC3494037
DC Field
Value
dc.contributor.authorPeters, BD
dc.contributor.authorSzeszko, PR
dc.contributor.authorRadua, J
dc.contributor.authorIkuta, T
dc.contributor.authorGruner, P
dc.contributor.authorDeRosse, P
dc.contributor.authorZhang, JP
dc.contributor.authorGiorgio, A
dc.contributor.authorQiu, D
dc.contributor.authorTapert, SF
dc.contributor.authorBrauer, J
dc.contributor.authorAsato, MR
dc.contributor.authorKhong, PL
dc.contributor.authorJames, AC
dc.contributor.authorGallego, JA
dc.contributor.authorMalhotra, AK
dc.date.accessioned2012-09-20T07:53:35Z
dc.date.available2012-09-20T07:53:35Z
dc.date.issued2012
dc.description.abstractBackground In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fractional anisotropy (FA), a putative measure of WM integrity, from childhood into adolescence. However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence. Methods DTI was performed in 78 healthy subjects aged 8-21 years, and voxel-wise analysis conducted using tract-based spatial statistics (TBSS). In addition, we performed the first meta-analysis of TBSS studies on WM development in adolescence. Results In our sample, we observed bilateral increases in FA with age, which were most significant in the left superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and anterior thalamic radiation. These findings were confirmed by the meta-analysis, and FA increase in the bilateral SLF was the most consistent finding across studies. Moreover, in our sample, FA of the bilateral SLF showed a positive association with verbal working memory performance and partially mediated increases in verbal fluency as a function of increasing age. Conclusions These data highlight increasing connectivity in the SLF during adolescence. In light of evidence for compromised SLF integrity in high-risk and first-episode patients, these data suggest that abnormal maturation of the SLF during adolescence may be a key target in the neurodevelopment of schizophrenia.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationSchizophrenia Bulletin, 2012, v. 38 n. 6, p. 1308-1317 [How to Cite?]
DOI: http://dx.doi.org/10.1093/schbul/sbs054
dc.identifier.doihttp://dx.doi.org/10.1093/schbul/sbs054
dc.identifier.epage1317
dc.identifier.hkuros206713
dc.identifier.issn0586-7614
2011 Impact Factor: 8.8
2011 SCImago Journal Rankings: 0.444
dc.identifier.issue6
dc.identifier.pmcidPMC3494037
dc.identifier.pmid22499780
dc.identifier.scopuseid_2-s2.0-84869021660
dc.identifier.spage1308
dc.identifier.urihttp://hdl.handle.net/10722/163938
dc.identifier.volume38
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofSchizophrenia Bulletin
dc.subjectControlled study
dc.subjectDiffusion tensor imaging
dc.subjectMedial longitudinal fasciculus
dc.subjectMeta analysis (topic)
dc.subjectNormal human
dc.titleWhite matter development in adolescence: diffusion tensor imaging and meta-analytic results
dc.typeArticle
Author Affiliations
  1. FIDMAG
  2. King's College London
  3. Stanford University
  4. Feinstein Institute for Medical Research
  5. The University of Hong Kong
  6. Max-Planck-Institut für Kognitions- und Neurowissenschaften
  7. The Zucker Hillside Hospital
  8. University of Pittsburgh
  9. University of California, San Diego
  10. Università degli Studi di Siena
  11. University of Oxford