File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: White matter development in adolescence: diffusion tensor imaging and meta-analytic results
  • Basic View
  • Metadata View
  • XML View
TitleWhite matter development in adolescence: diffusion tensor imaging and meta-analytic results
 
AuthorsPeters, BD7 4
Szeszko, PR7 4
Radua, J2 1
Ikuta, T7 4
Gruner, P7 4
DeRosse, P7 4
Zhang, JP7 4
Giorgio, A11 10
Qiu, D6 3
Tapert, SF9
Brauer, J5
Asato, MR8
Khong, PL6
James, AC11
Gallego, JA7 4
Malhotra, AK7 4
 
KeywordsControlled study
Diffusion tensor imaging
Medial longitudinal fasciculus
Meta analysis (topic)
Normal human
 
Issue Date2012
 
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
 
CitationSchizophrenia Bulletin, 2012, v. 38 n. 6, p. 1308-1317 [How to Cite?]
DOI: http://dx.doi.org/10.1093/schbul/sbs054
 
AbstractBackground In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fractional anisotropy (FA), a putative measure of WM integrity, from childhood into adolescence. However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence. Methods DTI was performed in 78 healthy subjects aged 8-21 years, and voxel-wise analysis conducted using tract-based spatial statistics (TBSS). In addition, we performed the first meta-analysis of TBSS studies on WM development in adolescence. Results In our sample, we observed bilateral increases in FA with age, which were most significant in the left superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and anterior thalamic radiation. These findings were confirmed by the meta-analysis, and FA increase in the bilateral SLF was the most consistent finding across studies. Moreover, in our sample, FA of the bilateral SLF showed a positive association with verbal working memory performance and partially mediated increases in verbal fluency as a function of increasing age. Conclusions These data highlight increasing connectivity in the SLF during adolescence. In light of evidence for compromised SLF integrity in high-risk and first-episode patients, these data suggest that abnormal maturation of the SLF during adolescence may be a key target in the neurodevelopment of schizophrenia.
 
ISSN0586-7614
2013 Impact Factor: 8.607
 
DOIhttp://dx.doi.org/10.1093/schbul/sbs054
 
PubMed Central IDPMC3494037
 
ISI Accession Number IDWOS:000310944500026
 
DC FieldValue
dc.contributor.authorPeters, BD
 
dc.contributor.authorSzeszko, PR
 
dc.contributor.authorRadua, J
 
dc.contributor.authorIkuta, T
 
dc.contributor.authorGruner, P
 
dc.contributor.authorDeRosse, P
 
dc.contributor.authorZhang, JP
 
dc.contributor.authorGiorgio, A
 
dc.contributor.authorQiu, D
 
dc.contributor.authorTapert, SF
 
dc.contributor.authorBrauer, J
 
dc.contributor.authorAsato, MR
 
dc.contributor.authorKhong, PL
 
dc.contributor.authorJames, AC
 
dc.contributor.authorGallego, JA
 
dc.contributor.authorMalhotra, AK
 
dc.date.accessioned2012-09-20T07:53:35Z
 
dc.date.available2012-09-20T07:53:35Z
 
dc.date.issued2012
 
dc.description.abstractBackground In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fractional anisotropy (FA), a putative measure of WM integrity, from childhood into adolescence. However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence. Methods DTI was performed in 78 healthy subjects aged 8-21 years, and voxel-wise analysis conducted using tract-based spatial statistics (TBSS). In addition, we performed the first meta-analysis of TBSS studies on WM development in adolescence. Results In our sample, we observed bilateral increases in FA with age, which were most significant in the left superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and anterior thalamic radiation. These findings were confirmed by the meta-analysis, and FA increase in the bilateral SLF was the most consistent finding across studies. Moreover, in our sample, FA of the bilateral SLF showed a positive association with verbal working memory performance and partially mediated increases in verbal fluency as a function of increasing age. Conclusions These data highlight increasing connectivity in the SLF during adolescence. In light of evidence for compromised SLF integrity in high-risk and first-episode patients, these data suggest that abnormal maturation of the SLF during adolescence may be a key target in the neurodevelopment of schizophrenia.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationSchizophrenia Bulletin, 2012, v. 38 n. 6, p. 1308-1317 [How to Cite?]
DOI: http://dx.doi.org/10.1093/schbul/sbs054
 
dc.identifier.doihttp://dx.doi.org/10.1093/schbul/sbs054
 
dc.identifier.epage1317
 
dc.identifier.hkuros206713
 
dc.identifier.isiWOS:000310944500026
 
dc.identifier.issn0586-7614
2013 Impact Factor: 8.607
 
dc.identifier.issue6
 
dc.identifier.pmcidPMC3494037
 
dc.identifier.pmid22499780
 
dc.identifier.scopuseid_2-s2.0-84869021660
 
dc.identifier.spage1308
 
dc.identifier.urihttp://hdl.handle.net/10722/163938
 
dc.identifier.volume38
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofSchizophrenia Bulletin
 
dc.subjectControlled study
 
dc.subjectDiffusion tensor imaging
 
dc.subjectMedial longitudinal fasciculus
 
dc.subjectMeta analysis (topic)
 
dc.subjectNormal human
 
dc.titleWhite matter development in adolescence: diffusion tensor imaging and meta-analytic results
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Peters, BD</contributor.author>
<contributor.author>Szeszko, PR</contributor.author>
<contributor.author>Radua, J</contributor.author>
<contributor.author>Ikuta, T</contributor.author>
<contributor.author>Gruner, P</contributor.author>
<contributor.author>DeRosse, P</contributor.author>
<contributor.author>Zhang, JP</contributor.author>
<contributor.author>Giorgio, A</contributor.author>
<contributor.author>Qiu, D</contributor.author>
<contributor.author>Tapert, SF</contributor.author>
<contributor.author>Brauer, J</contributor.author>
<contributor.author>Asato, MR</contributor.author>
<contributor.author>Khong, PL</contributor.author>
<contributor.author>James, AC</contributor.author>
<contributor.author>Gallego, JA</contributor.author>
<contributor.author>Malhotra, AK</contributor.author>
<date.accessioned>2012-09-20T07:53:35Z</date.accessioned>
<date.available>2012-09-20T07:53:35Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Schizophrenia Bulletin, 2012, v. 38 n. 6, p. 1308-1317</identifier.citation>
<identifier.issn>0586-7614</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/163938</identifier.uri>
<description.abstract>Background In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fractional anisotropy (FA), a putative measure of WM integrity, from childhood into adolescence. However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence. Methods DTI was performed in 78 healthy subjects aged 8-21 years, and voxel-wise analysis conducted using tract-based spatial statistics (TBSS). In addition, we performed the first meta-analysis of TBSS studies on WM development in adolescence. Results In our sample, we observed bilateral increases in FA with age, which were most significant in the left superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and anterior thalamic radiation. These findings were confirmed by the meta-analysis, and FA increase in the bilateral SLF was the most consistent finding across studies. Moreover, in our sample, FA of the bilateral SLF showed a positive association with verbal working memory performance and partially mediated increases in verbal fluency as a function of increasing age. Conclusions These data highlight increasing connectivity in the SLF during adolescence. In light of evidence for compromised SLF integrity in high-risk and first-episode patients, these data suggest that abnormal maturation of the SLF during adolescence may be a key target in the neurodevelopment of schizophrenia.</description.abstract>
<language>eng</language>
<publisher>Oxford University Press. The Journal&apos;s web site is located at http://schizophreniabulletin.oxfordjournals.org/</publisher>
<relation.ispartof>Schizophrenia Bulletin</relation.ispartof>
<subject>Controlled study</subject>
<subject>Diffusion tensor imaging</subject>
<subject>Medial longitudinal fasciculus</subject>
<subject>Meta analysis (topic)</subject>
<subject>Normal human</subject>
<title>White matter development in adolescence: diffusion tensor imaging and meta-analytic results</title>
<type>Article</type>
<description.nature>link_to_OA_fulltext</description.nature>
<identifier.doi>10.1093/schbul/sbs054</identifier.doi>
<identifier.pmid>22499780</identifier.pmid>
<identifier.pmcid>PMC3494037</identifier.pmcid>
<identifier.scopus>eid_2-s2.0-84869021660</identifier.scopus>
<identifier.hkuros>206713</identifier.hkuros>
<identifier.volume>38</identifier.volume>
<identifier.issue>6</identifier.issue>
<identifier.spage>1308</identifier.spage>
<identifier.epage>1317</identifier.epage>
<identifier.isi>WOS:000310944500026</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
<bitstream.url>http://hub.hku.hk/bitstream/10722/163938/1/re01.htm</bitstream.url>
</item>
Author Affiliations
  1. FIDMAG
  2. King's College London
  3. Stanford University
  4. Feinstein Institute for Medical Research
  5. Max-Planck-Institut für Kognitions- und Neurowissenschaften
  6. The University of Hong Kong
  7. The Zucker Hillside Hospital
  8. University of Pittsburgh
  9. University of California, San Diego
  10. Università degli Studi di Siena
  11. University of Oxford