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Article: White matter development in adolescence: diffusion tensor imaging and meta-analytic results

TitleWhite matter development in adolescence: diffusion tensor imaging and meta-analytic results
Authors
KeywordsControlled study
Diffusion tensor imaging
Medial longitudinal fasciculus
Meta analysis (topic)
Normal human
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
Schizophrenia Bulletin, 2012, v. 38 n. 6, p. 1308-1317 How to Cite?
AbstractBackground In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fractional anisotropy (FA), a putative measure of WM integrity, from childhood into adolescence. However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence. Methods DTI was performed in 78 healthy subjects aged 8-21 years, and voxel-wise analysis conducted using tract-based spatial statistics (TBSS). In addition, we performed the first meta-analysis of TBSS studies on WM development in adolescence. Results In our sample, we observed bilateral increases in FA with age, which were most significant in the left superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and anterior thalamic radiation. These findings were confirmed by the meta-analysis, and FA increase in the bilateral SLF was the most consistent finding across studies. Moreover, in our sample, FA of the bilateral SLF showed a positive association with verbal working memory performance and partially mediated increases in verbal fluency as a function of increasing age. Conclusions These data highlight increasing connectivity in the SLF during adolescence. In light of evidence for compromised SLF integrity in high-risk and first-episode patients, these data suggest that abnormal maturation of the SLF during adolescence may be a key target in the neurodevelopment of schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/163938
ISSN
2014 Impact Factor: 8.450
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPeters, BDen_US
dc.contributor.authorSzeszko, PRen_US
dc.contributor.authorRadua, Jen_US
dc.contributor.authorIkuta, Ten_US
dc.contributor.authorGruner, Pen_US
dc.contributor.authorDeRosse, Pen_US
dc.contributor.authorZhang, JPen_US
dc.contributor.authorGiorgio, Aen_US
dc.contributor.authorQiu, Den_US
dc.contributor.authorTapert, SFen_US
dc.contributor.authorBrauer, Jen_US
dc.contributor.authorAsato, MRen_US
dc.contributor.authorKhong, PLen_US
dc.contributor.authorJames, ACen_US
dc.contributor.authorGallego, JAen_US
dc.contributor.authorMalhotra, AKen_US
dc.date.accessioned2012-09-20T07:53:35Z-
dc.date.available2012-09-20T07:53:35Z-
dc.date.issued2012en_US
dc.identifier.citationSchizophrenia Bulletin, 2012, v. 38 n. 6, p. 1308-1317en_US
dc.identifier.issn0586-7614-
dc.identifier.urihttp://hdl.handle.net/10722/163938-
dc.description.abstractBackground In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fractional anisotropy (FA), a putative measure of WM integrity, from childhood into adolescence. However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence. Methods DTI was performed in 78 healthy subjects aged 8-21 years, and voxel-wise analysis conducted using tract-based spatial statistics (TBSS). In addition, we performed the first meta-analysis of TBSS studies on WM development in adolescence. Results In our sample, we observed bilateral increases in FA with age, which were most significant in the left superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and anterior thalamic radiation. These findings were confirmed by the meta-analysis, and FA increase in the bilateral SLF was the most consistent finding across studies. Moreover, in our sample, FA of the bilateral SLF showed a positive association with verbal working memory performance and partially mediated increases in verbal fluency as a function of increasing age. Conclusions These data highlight increasing connectivity in the SLF during adolescence. In light of evidence for compromised SLF integrity in high-risk and first-episode patients, these data suggest that abnormal maturation of the SLF during adolescence may be a key target in the neurodevelopment of schizophrenia.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/-
dc.relation.ispartofSchizophrenia Bulletinen_US
dc.subjectControlled study-
dc.subjectDiffusion tensor imaging-
dc.subjectMedial longitudinal fasciculus-
dc.subjectMeta analysis (topic)-
dc.subjectNormal human-
dc.titleWhite matter development in adolescence: diffusion tensor imaging and meta-analytic resultsen_US
dc.typeArticleen_US
dc.identifier.emailPeters, BD: BPeters1@NSHS.eduen_US
dc.identifier.emailQiu, D: dgiu@hku.hken_US
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hk-
dc.identifier.authorityKhong, PL=rp00467en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/schbul/sbs054-
dc.identifier.pmid22499780-
dc.identifier.pmcidPMC3494037-
dc.identifier.scopuseid_2-s2.0-84869021660-
dc.identifier.hkuros206713en_US
dc.identifier.volume38-
dc.identifier.issue6-
dc.identifier.spage1308-
dc.identifier.epage1317-
dc.identifier.isiWOS:000310944500026-
dc.publisher.placeUnited Kingdom-

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