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Article: Long-term hearing results and otological complications of nasopharyngeal carcinoma patients: comparison between treatment with conventional two-dimensional radiotherapy and intensity-modulated radiotherapy

TitleLong-term hearing results and otological complications of nasopharyngeal carcinoma patients: comparison between treatment with conventional two-dimensional radiotherapy and intensity-modulated radiotherapy
Authors
KeywordsAntineoplastic agent
Aged
Bone necrosis
Cancer chemotherapy
Cancer radiotherapy
Issue Date2012
PublisherS. Karger AG.
Citation
ORL: Journal for Oto-rhino-laryngology and Its Related Specialties, 2012, v. 74 n. 4, p. 228-233 How to Cite?
AbstractOBJECTIVE: To assess the long-term audiological outcome and otological complications of nasopharyngeal carcinoma patients who have received intensity-modulated radiotherapy (IMRT) versus conventional two-dimensional radiotherapy (2 DRT). STUDY DESIGN: Prospective study on the audiological outcome and otological complications 5-9 years after radiotherapy. METHODOLOGY: Patients had pure-tone audiogram before radiotherapy and 5 years after radiotherapy. Otological examination was performed 5-9 years after radiotherapy by an otolaryngologist. RESULTS: There is a significant deterioration of the hearing threshold 5 years after radiotherapy but there is no statistically significant difference in the deterioration of hearing between IMRT and 2 DRT. Six patients in the 2 DRT group and 1 patient in the IMRT group had osteoradionecrosis of the external auditory canal (p = 0.042). CONCLUSION: There are fewer incidences of osteoradionecrosis of the external auditory canal in patients treated with IMRT. There is no difference in bone conduction threshold in patients treated with IMRT or 2 DRT.
Persistent Identifierhttp://hdl.handle.net/10722/163919
ISSN
2015 Impact Factor: 1.0
2015 SCImago Journal Rankings: 0.564
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsang, RKen_US
dc.contributor.authorKwong, DLen_US
dc.contributor.authorHo, ACen_US
dc.contributor.authorTo, VSen_US
dc.contributor.authorHo, WKen_US
dc.contributor.authorWei, WIen_US
dc.date.accessioned2012-09-20T07:53:09Z-
dc.date.available2012-09-20T07:53:09Z-
dc.date.issued2012en_US
dc.identifier.citationORL: Journal for Oto-rhino-laryngology and Its Related Specialties, 2012, v. 74 n. 4, p. 228-233en_US
dc.identifier.issn0301-1569-
dc.identifier.urihttp://hdl.handle.net/10722/163919-
dc.description.abstractOBJECTIVE: To assess the long-term audiological outcome and otological complications of nasopharyngeal carcinoma patients who have received intensity-modulated radiotherapy (IMRT) versus conventional two-dimensional radiotherapy (2 DRT). STUDY DESIGN: Prospective study on the audiological outcome and otological complications 5-9 years after radiotherapy. METHODOLOGY: Patients had pure-tone audiogram before radiotherapy and 5 years after radiotherapy. Otological examination was performed 5-9 years after radiotherapy by an otolaryngologist. RESULTS: There is a significant deterioration of the hearing threshold 5 years after radiotherapy but there is no statistically significant difference in the deterioration of hearing between IMRT and 2 DRT. Six patients in the 2 DRT group and 1 patient in the IMRT group had osteoradionecrosis of the external auditory canal (p = 0.042). CONCLUSION: There are fewer incidences of osteoradionecrosis of the external auditory canal in patients treated with IMRT. There is no difference in bone conduction threshold in patients treated with IMRT or 2 DRT.-
dc.languageengen_US
dc.publisherS. Karger AG.en_US
dc.relation.ispartofORL: Journal for Oto-rhino-laryngology and Its Related Specialtiesen_US
dc.rightsORL: Journal for Oto-rhino-laryngology and Its Related Specialties. Copyright © S. Karger AG.en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAntineoplastic agent-
dc.subjectAged-
dc.subjectBone necrosis-
dc.subjectCancer chemotherapy-
dc.subjectCancer radiotherapy-
dc.titleLong-term hearing results and otological complications of nasopharyngeal carcinoma patients: comparison between treatment with conventional two-dimensional radiotherapy and intensity-modulated radiotherapyen_US
dc.typeArticleen_US
dc.identifier.emailTsang, RK: rkytsang@hku.hken_US
dc.identifier.emailKwong, DL: dlwkwong@hku.hken_US
dc.identifier.emailHo, AC: aho1@hku.hken_US
dc.identifier.emailTo, VS: doctorto@hku.hken_US
dc.identifier.emailHo, WK: wkho@hkucc.hku.hken_US
dc.identifier.emailWei, WI: hrmswwi@hku.hken_US
dc.identifier.authorityTsang, RK=rp01386en_US
dc.identifier.authorityKwong, DL=rp00414en_US
dc.identifier.authorityTo, VS=rp01385en_US
dc.identifier.authorityWei, WI=rp00323en_US
dc.description.naturepostprint-
dc.identifier.doi10.1159/000341096-
dc.identifier.pmid22907195-
dc.identifier.scopuseid_2-s2.0-84865048392-
dc.identifier.hkuros209876en_US
dc.identifier.hkuros210070-
dc.identifier.volume74en_US
dc.identifier.issue4en_US
dc.identifier.spage228en_US
dc.identifier.epage233en_US
dc.identifier.isiWOS:000309143800008-
dc.publisher.placeSwitzerland-

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