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Article: Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential

TitleQuaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential
Authors
KeywordsAntimicrobial
Organic modified silicate
Quaternary ammonium
Self-repair
Sol-gel technique
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
Citation
Acta Biomaterialia, 2012, v. 8 n. 9, p. 3270-3282 How to Cite?
AbstractThe design of antimicrobial polymers to address healthcare issues and minimize environmental problems is an important endeavor with both fundamental and practical implications. Quaternary ammonium silane-functionalized methacrylate (QAMS) represents an example of antimicrobial macromonomers synthesized by a sol-gel chemical route; these compounds possess flexible Si-O-Si bonds. In present work, a partially hydrolyzed QAMS co-polymerized with 2,2-[4(2-hydroxy 3-methacryloxypropoxy)-phenyl]propane is introduced. This methacrylate resin was shown to possess desirable mechanical properties with both a high degree of conversion and minimal polymerization shrinkage. The kill-on-contact microbiocidal activities of this resin were demonstrated using single-species biofilms of Streptococcus mutans (ATCC 36558), Actinomyces naeslundii (ATCC 12104) and Candida albicans (ATCC 90028). Improved mechanical properties after hydration provided the proof-of-concept that QAMS-incorporated resin exhibits self-repair potential via water-induced condensation of organic modified silicate (ormosil) phases within the polymerized resin matrix. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163744
ISSN
2015 Impact Factor: 6.008
2015 SCImago Journal Rankings: 2.020
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGong, SQen_US
dc.contributor.authorNiu, LNen_US
dc.contributor.authorKemp, LKen_US
dc.contributor.authorYiu, CKYen_US
dc.contributor.authorRyou, Hen_US
dc.contributor.authorQI, YPen_US
dc.contributor.authorBlizzard, JDen_US
dc.contributor.authorNikonov, Sen_US
dc.contributor.authorBrackett, MGen_US
dc.contributor.authorMesser, RLWen_US
dc.contributor.authorWu, CDen_US
dc.contributor.authorMao, Len_US
dc.contributor.authorBrister, LBen_US
dc.contributor.authorRueggeberg, FAen_US
dc.contributor.authorArola, DDen_US
dc.contributor.authorPashley, DHen_US
dc.contributor.authorTay, FRen_US
dc.date.accessioned2012-09-20T07:50:37Z-
dc.date.available2012-09-20T07:50:37Z-
dc.date.issued2012en_US
dc.identifier.citationActa Biomaterialia, 2012, v. 8 n. 9, p. 3270-3282en_US
dc.identifier.issn1742-7061-
dc.identifier.urihttp://hdl.handle.net/10722/163744-
dc.description.abstractThe design of antimicrobial polymers to address healthcare issues and minimize environmental problems is an important endeavor with both fundamental and practical implications. Quaternary ammonium silane-functionalized methacrylate (QAMS) represents an example of antimicrobial macromonomers synthesized by a sol-gel chemical route; these compounds possess flexible Si-O-Si bonds. In present work, a partially hydrolyzed QAMS co-polymerized with 2,2-[4(2-hydroxy 3-methacryloxypropoxy)-phenyl]propane is introduced. This methacrylate resin was shown to possess desirable mechanical properties with both a high degree of conversion and minimal polymerization shrinkage. The kill-on-contact microbiocidal activities of this resin were demonstrated using single-species biofilms of Streptococcus mutans (ATCC 36558), Actinomyces naeslundii (ATCC 12104) and Candida albicans (ATCC 90028). Improved mechanical properties after hydration provided the proof-of-concept that QAMS-incorporated resin exhibits self-repair potential via water-induced condensation of organic modified silicate (ormosil) phases within the polymerized resin matrix. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.-
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat-
dc.relation.ispartofActa Biomaterialiaen_US
dc.subjectAntimicrobial-
dc.subjectOrganic modified silicate-
dc.subjectQuaternary ammonium-
dc.subjectSelf-repair-
dc.subjectSol-gel technique-
dc.titleQuaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potentialen_US
dc.typeArticleen_US
dc.identifier.emailYiu, CKY: ckyyiu@hkucc.hku.hken_US
dc.identifier.emailTay, FR: ftay@georgiahealth.edu-
dc.identifier.authorityYiu, CKY=rp00018en_US
dc.identifier.doi10.1016/j.actbio.2012.05.031-
dc.identifier.pmid22659173-
dc.identifier.scopuseid_2-s2.0-84864405615-
dc.identifier.hkuros210269en_US
dc.identifier.volume8en_US
dc.identifier.issue9-
dc.identifier.spage3270en_US
dc.identifier.epage3282en_US
dc.identifier.isiWOS:000307625900009-
dc.publisher.placeNetherlands-

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