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Conference Paper: Characterizing the micromechanical properties of myeloblasts from cancer patients with optical tweezers

TitleCharacterizing the micromechanical properties of myeloblasts from cancer patients with optical tweezers
Authors
KeywordsAcute myeloid leukemia
Area compressibility
Biophysical properties
Bone marrow
Cancer patients
Cell mechanics
Cell state
Hematopoietic cell
Intrinsic property
Mechanical response
Micromechanical property
Single-cell level
Stretching force
Theoretical approach
Unique features
Issue Date2010
PublisherIEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1800098
Citation
The 4th IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE NANOMED 2010), Hong Kong/Macau, China, 5-9 December 2010. In Conference Proceedings, 2010, p. 30-33 How to Cite?
AbstractCell mechanics, in particular mechanical properties, has been suggested as a new biomarker indicative of cell state and phenotype. Acute myeloid leukemia (AML) is characterized by the abnormal increase of myeloblasts in blood and bone marrow. While AML has been extensively studied from the perspectives of biochemical and genetic aspects, little is known about its cellular biophysical properties. In this study, optical tweezer technology was used to examine the micromechanical properties of myeloblasts from bone marrow of AML patients at single cell level. The myeloblasts were separately analyzed according to their expression of CD34 +, a marker of primitive hematopoietic cells. To extract the intrinsic properties from the relationship between the stretching force and the induced deformation, a theoretical approach was developed to model the mechanical responses of cells and further characterize their mechanical properties. The preliminary results show that the area compressibility modulus of CD34 + myeloblasts was significantly less than that of CD34 - cells, which indicate that micromechanical properties are unique features of myeloblasts and provide us with an insight into the cell mechanics of primitive AML cells. © 2010 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/163574
ISBN
References

 

DC FieldValueLanguage
dc.contributor.authorTan, Yen_US
dc.contributor.authorLeung, AYHen_US
dc.contributor.authorWang, Ken_US
dc.contributor.authorFung, TKen_US
dc.contributor.authorSun, Den_US
dc.date.accessioned2012-09-05T05:37:29Z-
dc.date.available2012-09-05T05:37:29Z-
dc.date.issued2010en_US
dc.identifier.citationThe 4th IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE NANOMED 2010), Hong Kong/Macau, China, 5-9 December 2010. In Conference Proceedings, 2010, p. 30-33en_US
dc.identifier.isbn978-1-61284-154-0-
dc.identifier.urihttp://hdl.handle.net/10722/163574-
dc.description.abstractCell mechanics, in particular mechanical properties, has been suggested as a new biomarker indicative of cell state and phenotype. Acute myeloid leukemia (AML) is characterized by the abnormal increase of myeloblasts in blood and bone marrow. While AML has been extensively studied from the perspectives of biochemical and genetic aspects, little is known about its cellular biophysical properties. In this study, optical tweezer technology was used to examine the micromechanical properties of myeloblasts from bone marrow of AML patients at single cell level. The myeloblasts were separately analyzed according to their expression of CD34 +, a marker of primitive hematopoietic cells. To extract the intrinsic properties from the relationship between the stretching force and the induced deformation, a theoretical approach was developed to model the mechanical responses of cells and further characterize their mechanical properties. The preliminary results show that the area compressibility modulus of CD34 + myeloblasts was significantly less than that of CD34 - cells, which indicate that micromechanical properties are unique features of myeloblasts and provide us with an insight into the cell mechanics of primitive AML cells. © 2010 IEEE.en_US
dc.languageengen_US
dc.publisherIEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1800098-
dc.relation.ispartofIEEE International Conference on Nano/Molecular Medicine and Engineering Proceedingsen_US
dc.rightsIEEE International Conference on Nano/Molecular Medicine and Engineering Proceedings. Copyright © IEEE.-
dc.rights©2010 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAcute myeloid leukemia-
dc.subjectArea compressibility-
dc.subjectBiophysical properties-
dc.subjectBone marrow-
dc.subjectCancer patients-
dc.subjectCell mechanics-
dc.subjectCell state-
dc.subjectHematopoietic cell-
dc.subjectIntrinsic property-
dc.subjectMechanical response-
dc.subjectMicromechanical property-
dc.subjectSingle-cell level-
dc.subjectStretching force-
dc.subjectTheoretical approach-
dc.subjectUnique features-
dc.titleCharacterizing the micromechanical properties of myeloblasts from cancer patients with optical tweezersen_US
dc.typeConference_Paperen_US
dc.identifier.emailLeung, AYH: ayhleung@hku.hken_US
dc.identifier.emailFung, TK: fungkan@hkucc.hku.hk-
dc.identifier.authorityLeung, AYH=rp00265en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1109/NANOMED.2010.5749800en_US
dc.identifier.scopuseid_2-s2.0-79956031895en_US
dc.identifier.hkuros223520-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956031895&selection=ref&src=s&origin=recordpageen_US
dc.identifier.spage30en_US
dc.identifier.epage33en_US
dc.publisher.placeUnited States-
dc.identifier.scopusauthoridSun, D=7403968591en_US
dc.identifier.scopusauthoridFung, TK=7102715924en_US
dc.identifier.scopusauthoridWang, K=37562173800en_US
dc.identifier.scopusauthoridLeung, AYH=7403012668en_US
dc.identifier.scopusauthoridTan, Y=26028707000en_US
dc.customcontrol.immutablesml 131031-

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