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Conference Paper: Helicobacter pylori infection and gastric cancer

TitleHelicobacter pylori infection and gastric cancer
Authors
Issue Date2001
PublisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
Citation
Asian Journal Of Surgery, 2001, v. 24 n. 3, p. 217-221 How to Cite?
AbstractGastric cancer is the second most common fatal malignancy in the world. Prospective case-control studies have shown that subjects with H. pylori infection have an increased (by 2 to 4 folds) risk of development of gastric cancer. Animal studies have confirmed that infection with H. pylori results in the development of gastric cancer in Mongolian gerbils. H. pylori infection leads to changes of many factors that are important in the pathogenesis of gastric cancer, such as decrease in the ascorbic acid (vitamin C) level in gastric juice, increase in reactive oxygen metabolites, and imbalance between epithelial cell proliferation and apoptosis. Specific virulent strain and host factors may both contribute to the carcinogenesis of gastric cancer. Eradication of H. pylori infection may provide a powerful strategy in the prevention of gastric cancer. Whereas studies of patients with precancerous lesions have produced conflicting results regarding whether these lesions are reversible after eradication of the infection, chemoprevention trials on asymptomatic subjects are cautiously carried out in high risk populations. Vaccination may be proven to be the optimal strategy in humans in the management of H. pylori infection and thus prevention of gastric cancer.
Persistent Identifierhttp://hdl.handle.net/10722/163551
ISSN
2015 Impact Factor: 0.912
2015 SCImago Journal Rankings: 0.427
References

 

DC FieldValueLanguage
dc.contributor.authorXia, HHXen_US
dc.contributor.authorWong, BCYen_US
dc.contributor.authorLam, SKen_US
dc.date.accessioned2012-09-05T05:37:21Z-
dc.date.available2012-09-05T05:37:21Z-
dc.date.issued2001en_US
dc.identifier.citationAsian Journal Of Surgery, 2001, v. 24 n. 3, p. 217-221en_US
dc.identifier.issn1015-9584en_US
dc.identifier.urihttp://hdl.handle.net/10722/163551-
dc.description.abstractGastric cancer is the second most common fatal malignancy in the world. Prospective case-control studies have shown that subjects with H. pylori infection have an increased (by 2 to 4 folds) risk of development of gastric cancer. Animal studies have confirmed that infection with H. pylori results in the development of gastric cancer in Mongolian gerbils. H. pylori infection leads to changes of many factors that are important in the pathogenesis of gastric cancer, such as decrease in the ascorbic acid (vitamin C) level in gastric juice, increase in reactive oxygen metabolites, and imbalance between epithelial cell proliferation and apoptosis. Specific virulent strain and host factors may both contribute to the carcinogenesis of gastric cancer. Eradication of H. pylori infection may provide a powerful strategy in the prevention of gastric cancer. Whereas studies of patients with precancerous lesions have produced conflicting results regarding whether these lesions are reversible after eradication of the infection, chemoprevention trials on asymptomatic subjects are cautiously carried out in high risk populations. Vaccination may be proven to be the optimal strategy in humans in the management of H. pylori infection and thus prevention of gastric cancer.en_US
dc.languageengen_US
dc.publisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#descriptionen_US
dc.relation.ispartofAsian Journal of Surgeryen_US
dc.titleHelicobacter pylori infection and gastric canceren_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0034852896en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034852896&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue3en_US
dc.identifier.spage217en_US
dc.identifier.epage221en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridXia, HHX=8757161400en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US

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