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Article: The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9

TitleThe t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
Authors
Issue Date1996
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 1996, v. 12 n. 2, p. 159-167 How to Cite?
AbstractThe t(7;11)(p15;p15) translocation is a recurrent chromosomal abnormality associated primarily with acute myeloid leukaemia (FAB M2 and M4). We present here the molecular definition of this translocation. On chromosome 7 positional cloning revealed the consistent rearrangement of the HOXA9 gene, which encodes a class I homeodomain protein potentially involved in myeloid differentiation. On chromosome 11 the translocation targets the human homologue of NUP98, a member of the GLFG nucleoporin family. Chimaeric messages spliced over the breakpoint fuse the GLFG repeat domains of NUP98 in-frame to the HOXA9 homeobox. The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport.
Persistent Identifierhttp://hdl.handle.net/10722/163520
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBorrow, Jen_US
dc.contributor.authorShearman, AMen_US
dc.contributor.authorStanton Jr, VPen_US
dc.contributor.authorBecher, Ren_US
dc.contributor.authorCollins, Ten_US
dc.contributor.authorWilliams, AJen_US
dc.contributor.authorDubé, Ien_US
dc.contributor.authorKatz, Fen_US
dc.contributor.authorKwong, YLen_US
dc.contributor.authorMorris, Cen_US
dc.contributor.authorOhyashiki, Ken_US
dc.contributor.authorToyama, Ken_US
dc.contributor.authorRowley, Jen_US
dc.contributor.authorHousman, DEen_US
dc.date.accessioned2012-09-05T05:33:03Z-
dc.date.available2012-09-05T05:33:03Z-
dc.date.issued1996en_US
dc.identifier.citationNature Genetics, 1996, v. 12 n. 2, p. 159-167en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttp://hdl.handle.net/10722/163520-
dc.description.abstractThe t(7;11)(p15;p15) translocation is a recurrent chromosomal abnormality associated primarily with acute myeloid leukaemia (FAB M2 and M4). We present here the molecular definition of this translocation. On chromosome 7 positional cloning revealed the consistent rearrangement of the HOXA9 gene, which encodes a class I homeodomain protein potentially involved in myeloid differentiation. On chromosome 11 the translocation targets the human homologue of NUP98, a member of the GLFG nucleoporin family. Chimaeric messages spliced over the breakpoint fuse the GLFG repeat domains of NUP98 in-frame to the HOXA9 homeobox. The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_US
dc.relation.ispartofNature Geneticsen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 11en_US
dc.subject.meshChromosomes, Human, Pair 7en_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshHomeodomain Proteins - Genetics - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myelomonocytic, Acute - Geneticsen_US
dc.subject.meshMembrane Proteins - Geneticsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNuclear Pore Complex Proteinsen_US
dc.subject.meshNuclear Proteins - Geneticsen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshRna, Neoplasm - Geneticsen_US
dc.subject.meshRepetitive Sequences, Nucleic Acid - Geneticsen_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleThe t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9en_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ng0296-159en_US
dc.identifier.pmid8563754-
dc.identifier.scopuseid_2-s2.0-9044249724en_US
dc.identifier.hkuros13463-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9044249724&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue2en_US
dc.identifier.spage159en_US
dc.identifier.epage167en_US
dc.identifier.isiWOS:A1996TU07900016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBorrow, J=7004496644en_US
dc.identifier.scopusauthoridShearman, AM=6602645935en_US
dc.identifier.scopusauthoridStanton Jr, VP=6604018137en_US
dc.identifier.scopusauthoridBecher, R=35419922900en_US
dc.identifier.scopusauthoridCollins, T=7201800851en_US
dc.identifier.scopusauthoridWilliams, AJ=7405835220en_US
dc.identifier.scopusauthoridDubé, I=7005148762en_US
dc.identifier.scopusauthoridKatz, F=35419872700en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridMorris, C=7401472993en_US
dc.identifier.scopusauthoridOhyashiki, K=35379337200en_US
dc.identifier.scopusauthoridToyama, K=35370179600en_US
dc.identifier.scopusauthoridRowley, J=7201756491en_US
dc.identifier.scopusauthoridHousman, DE=7102570207en_US

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