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Article: Pathophysiology of gastroesophageal reflux diseases in Chinese - Role of transient lower esophageal sphincter relaxation and esophageal motor dysfunction
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TitlePathophysiology of gastroesophageal reflux diseases in Chinese - Role of transient lower esophageal sphincter relaxation and esophageal motor dysfunction
 
AuthorsWong, WM1
Lai, KC1
Hui, WM1
Hu, WHC1
Huang, JQ1
Wong, NYH1
Xia, HHX1
Chan, OO1
Lam, SK1
Wong, BCY1
 
Issue Date2004
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
 
CitationAmerican Journal Of Gastroenterology, 2004, v. 99 n. 11, p. 2088-2093 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1572-0241.2004.30417.x
 
AbstractBACKGROUND: Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism for AND AIMS: gastroesophageal reflux in the Western population. The major reflux mechanism in Chinese patients with GERD has not been studied before. METHODS: Fifty-four patients with GERD and 28 controls underwent stationary baseline manometry and the 24-h ambulatory esophageal pH monitoring. TLESRs were measured before and after an 850 kcal meal in the supine position. Primary peristalsis, secondary peristalsis, and esophageal acid clearance were measured by esophageal manometry. RESULTS: Total time esophageal pH ≤ 4 (7.3 vs 1.5, p = 0.001) was significantly higher in patients with GERD when compared to controls. Majority of acid reflux episodes was due to TLESR in both patients with GERD and controls. The frequency of TLESRs after meal was similar between patients with GERD and controls (1.0 vs 1.3/h, p = 0.34). There was no difference in the distribution of reflux mechanism between patients with GERD and controls. However, patients with GERD had a significantly lower successful primary peristalsis (59% vs 70%, p = 0.043) when compared to controls. CONCLUSION: The frequency of TLESRs was similar between patients with GERD and controls during stationary manometry. Primary peristalsis was impaired in Chinese patients with GERD. Esophageal motor dysfunction may contribute to the pathophysiology of GERD in the Chinese population.
 
ISSN0002-9270
2013 Impact Factor: 9.213
 
DOIhttp://dx.doi.org/10.1111/j.1572-0241.2004.30417.x
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, WM
 
dc.contributor.authorLai, KC
 
dc.contributor.authorHui, WM
 
dc.contributor.authorHu, WHC
 
dc.contributor.authorHuang, JQ
 
dc.contributor.authorWong, NYH
 
dc.contributor.authorXia, HHX
 
dc.contributor.authorChan, OO
 
dc.contributor.authorLam, SK
 
dc.contributor.authorWong, BCY
 
dc.date.accessioned2012-09-05T05:33:00Z
 
dc.date.available2012-09-05T05:33:00Z
 
dc.date.issued2004
 
dc.description.abstractBACKGROUND: Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism for AND AIMS: gastroesophageal reflux in the Western population. The major reflux mechanism in Chinese patients with GERD has not been studied before. METHODS: Fifty-four patients with GERD and 28 controls underwent stationary baseline manometry and the 24-h ambulatory esophageal pH monitoring. TLESRs were measured before and after an 850 kcal meal in the supine position. Primary peristalsis, secondary peristalsis, and esophageal acid clearance were measured by esophageal manometry. RESULTS: Total time esophageal pH ≤ 4 (7.3 vs 1.5, p = 0.001) was significantly higher in patients with GERD when compared to controls. Majority of acid reflux episodes was due to TLESR in both patients with GERD and controls. The frequency of TLESRs after meal was similar between patients with GERD and controls (1.0 vs 1.3/h, p = 0.34). There was no difference in the distribution of reflux mechanism between patients with GERD and controls. However, patients with GERD had a significantly lower successful primary peristalsis (59% vs 70%, p = 0.043) when compared to controls. CONCLUSION: The frequency of TLESRs was similar between patients with GERD and controls during stationary manometry. Primary peristalsis was impaired in Chinese patients with GERD. Esophageal motor dysfunction may contribute to the pathophysiology of GERD in the Chinese population.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Gastroenterology, 2004, v. 99 n. 11, p. 2088-2093 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1572-0241.2004.30417.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1572-0241.2004.30417.x
 
dc.identifier.epage2093
 
dc.identifier.hkuros96447
 
dc.identifier.issn0002-9270
2013 Impact Factor: 9.213
 
dc.identifier.issue11
 
dc.identifier.pmid15554985
 
dc.identifier.scopuseid_2-s2.0-8744299479
 
dc.identifier.spage2088
 
dc.identifier.urihttp://hdl.handle.net/10722/163518
 
dc.identifier.volume99
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Gastroenterology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAsian Continental Ancestry Group
 
dc.subject.meshEsophageal Sphincter, Lower - Physiopathology
 
dc.subject.meshEsophagitis, Peptic - Ethnology - Physiopathology
 
dc.subject.meshEsophagus - Physiopathology
 
dc.subject.meshFemale
 
dc.subject.meshGastroesophageal Reflux - Ethnology - Physiopathology
 
dc.subject.meshHumans
 
dc.subject.meshHydrogen-Ion Concentration
 
dc.subject.meshMale
 
dc.subject.meshManometry
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMonitoring, Ambulatory
 
dc.subject.meshMuscle Relaxation
 
dc.subject.meshPeristalsis
 
dc.titlePathophysiology of gastroesophageal reflux diseases in Chinese - Role of transient lower esophageal sphincter relaxation and esophageal motor dysfunction
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong