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Article: Left ventricular mechanical dyssynchrony impairs exercise capacity in patients with coronary artery disease with preserved left ventricular systolic function and a QRS duration ≤120 ms

TitleLeft ventricular mechanical dyssynchrony impairs exercise capacity in patients with coronary artery disease with preserved left ventricular systolic function and a QRS duration ≤120 ms
Authors
KeywordsCoronary Artery Disease
Exercise Capacity
Left Ventricular Dyssynchrony
Myocardial Infarction
Regional Wall Motion Abnormality
Issue Date2012
PublisherJapanese Circulation Society. The Journal's web site is located at http://www.j-circ.or.jp/english/publications/
Citation
Circulation Journal, 2012, v. 76 n. 3, p. 682-688 How to Cite?
AbstractBackground: Left ventricular (LV) mechanical dyssynchrony can lead to impairment of LV function and is associated with adverse clinical outcomes in coronary artery disease (CAD) patients. The impact of LV dyssynchrony on exercise capacity (EC) in patients with CAD was investigated. Methods and Results: An echocardiographic examination with tissue Doppler imaging and exercise treadmill testing in 151 CAD patients with normal LV ejection fraction was performed. LV intra- and inter-ventricular dyssynchrony were defined by the standard deviation of time interval between LV 6 basal segments (Ts-SD), and the time interval from the right ventricular (RV) free wall to LV lateral wall (Ts-RV) respectively, and EC was measured as metabolic equivalents (METs) on the treadmill. Patients with impaired EC (defined by a METs ≤8, which is the mean MET of the study population) were older (71±7 vs. 62±2 years, P<0.01), however, there were no differences in gender and clinical status such as prevalence of prior myocardial infarction (MI), regional wall motion abnormality (RWMA), and coronary revascularization between patients with (n=90) or without (n=61) impaired EC. Univariate analysis showed that age, body mass index, LV systolic and diastolic volume, mitral inflow A velocity, and Ts-SD were all significantly associated with METs (all P<0.05). However, multivariate regression analysis revealed that old age (odd ratio [OR]: 1.136, 95% confidence interval [CI]: 1.080-1.196, P<0.001), and Ts-SD (OR: 1.026, 95%CI: 1.003-1.049, P=0.027) only were independent predictors for impaired EC. Conclusions: In patients with CAD, LV systolic dyssynchrony predicts impaired EC independently of history of previous MI or RWMA.
Persistent Identifierhttp://hdl.handle.net/10722/163506
ISSN
2014 Impact Factor: 3.940
2014 SCImago Journal Rankings: 1.416
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Men_US
dc.contributor.authorYan, GHen_US
dc.contributor.authorYue, WSen_US
dc.contributor.authorSiu, CWen_US
dc.contributor.authorYiu, KHen_US
dc.contributor.authorLee, SWLen_US
dc.contributor.authorLau, CPen_US
dc.contributor.authorTse, HFen_US
dc.date.accessioned2012-09-05T05:32:43Z-
dc.date.available2012-09-05T05:32:43Z-
dc.date.issued2012en_US
dc.identifier.citationCirculation Journal, 2012, v. 76 n. 3, p. 682-688en_US
dc.identifier.issn1346-9843en_US
dc.identifier.urihttp://hdl.handle.net/10722/163506-
dc.description.abstractBackground: Left ventricular (LV) mechanical dyssynchrony can lead to impairment of LV function and is associated with adverse clinical outcomes in coronary artery disease (CAD) patients. The impact of LV dyssynchrony on exercise capacity (EC) in patients with CAD was investigated. Methods and Results: An echocardiographic examination with tissue Doppler imaging and exercise treadmill testing in 151 CAD patients with normal LV ejection fraction was performed. LV intra- and inter-ventricular dyssynchrony were defined by the standard deviation of time interval between LV 6 basal segments (Ts-SD), and the time interval from the right ventricular (RV) free wall to LV lateral wall (Ts-RV) respectively, and EC was measured as metabolic equivalents (METs) on the treadmill. Patients with impaired EC (defined by a METs ≤8, which is the mean MET of the study population) were older (71±7 vs. 62±2 years, P<0.01), however, there were no differences in gender and clinical status such as prevalence of prior myocardial infarction (MI), regional wall motion abnormality (RWMA), and coronary revascularization between patients with (n=90) or without (n=61) impaired EC. Univariate analysis showed that age, body mass index, LV systolic and diastolic volume, mitral inflow A velocity, and Ts-SD were all significantly associated with METs (all P<0.05). However, multivariate regression analysis revealed that old age (odd ratio [OR]: 1.136, 95% confidence interval [CI]: 1.080-1.196, P<0.001), and Ts-SD (OR: 1.026, 95%CI: 1.003-1.049, P=0.027) only were independent predictors for impaired EC. Conclusions: In patients with CAD, LV systolic dyssynchrony predicts impaired EC independently of history of previous MI or RWMA.en_US
dc.languageengen_US
dc.publisherJapanese Circulation Society. The Journal's web site is located at http://www.j-circ.or.jp/english/publications/en_US
dc.relation.ispartofCirculation Journalen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectExercise Capacityen_US
dc.subjectLeft Ventricular Dyssynchronyen_US
dc.subjectMyocardial Infarctionen_US
dc.subjectRegional Wall Motion Abnormalityen_US
dc.titleLeft ventricular mechanical dyssynchrony impairs exercise capacity in patients with coronary artery disease with preserved left ventricular systolic function and a QRS duration ≤120 msen_US
dc.typeArticleen_US
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_US
dc.identifier.authorityWang, M=rp00281en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1253/circj.CJ-11-0735en_US
dc.identifier.pmid22240594-
dc.identifier.scopuseid_2-s2.0-84863254532en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863254532&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume76en_US
dc.identifier.issue3en_US
dc.identifier.spage682en_US
dc.identifier.epage688en_US
dc.identifier.isiWOS:000300922900028-
dc.publisher.placeJapanen_US
dc.identifier.scopusauthoridWang, M=7406690398en_US
dc.identifier.scopusauthoridYan, GH=36544693600en_US
dc.identifier.scopusauthoridYue, WS=36106565300en_US
dc.identifier.scopusauthoridSiu, CW=55164929800en_US
dc.identifier.scopusauthoridYiu, KH=55035807600en_US
dc.identifier.scopusauthoridLee, SWL=53881501100en_US
dc.identifier.scopusauthoridLau, CP=35275317200en_US
dc.identifier.scopusauthoridTse, HF=54886126900en_US

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