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Article: Left ventricular mechanical dyssynchrony impairs exercise capacity in patients with coronary artery disease with preserved left ventricular systolic function and a QRS duration ≤120 ms
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TitleLeft ventricular mechanical dyssynchrony impairs exercise capacity in patients with coronary artery disease with preserved left ventricular systolic function and a QRS duration ≤120 ms
 
AuthorsWang, M2 1
Yan, GH2
Yue, WS2
Siu, CW2 1
Yiu, KH2
Lee, SWL2
Lau, CP2
Tse, HF2 1
 
KeywordsCoronary Artery Disease
Exercise Capacity
Left Ventricular Dyssynchrony
Myocardial Infarction
Regional Wall Motion Abnormality
 
Issue Date2012
 
PublisherJapanese Circulation Society. The Journal's web site is located at http://www.j-circ.or.jp/english/publications/
 
CitationCirculation Journal, 2012, v. 76 n. 3, p. 682-688 [How to Cite?]
DOI: http://dx.doi.org/10.1253/circj.CJ-11-0735
 
AbstractBackground: Left ventricular (LV) mechanical dyssynchrony can lead to impairment of LV function and is associated with adverse clinical outcomes in coronary artery disease (CAD) patients. The impact of LV dyssynchrony on exercise capacity (EC) in patients with CAD was investigated. Methods and Results: An echocardiographic examination with tissue Doppler imaging and exercise treadmill testing in 151 CAD patients with normal LV ejection fraction was performed. LV intra- and inter-ventricular dyssynchrony were defined by the standard deviation of time interval between LV 6 basal segments (Ts-SD), and the time interval from the right ventricular (RV) free wall to LV lateral wall (Ts-RV) respectively, and EC was measured as metabolic equivalents (METs) on the treadmill. Patients with impaired EC (defined by a METs ≤8, which is the mean MET of the study population) were older (71±7 vs. 62±2 years, P<0.01), however, there were no differences in gender and clinical status such as prevalence of prior myocardial infarction (MI), regional wall motion abnormality (RWMA), and coronary revascularization between patients with (n=90) or without (n=61) impaired EC. Univariate analysis showed that age, body mass index, LV systolic and diastolic volume, mitral inflow A velocity, and Ts-SD were all significantly associated with METs (all P<0.05). However, multivariate regression analysis revealed that old age (odd ratio [OR]: 1.136, 95% confidence interval [CI]: 1.080-1.196, P<0.001), and Ts-SD (OR: 1.026, 95%CI: 1.003-1.049, P=0.027) only were independent predictors for impaired EC. Conclusions: In patients with CAD, LV systolic dyssynchrony predicts impaired EC independently of history of previous MI or RWMA.
 
ISSN1346-9843
2012 Impact Factor: 3.578
2012 SCImago Journal Rankings: 1.337
 
DOIhttp://dx.doi.org/10.1253/circj.CJ-11-0735
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWang, M
 
dc.contributor.authorYan, GH
 
dc.contributor.authorYue, WS
 
dc.contributor.authorSiu, CW
 
dc.contributor.authorYiu, KH
 
dc.contributor.authorLee, SWL
 
dc.contributor.authorLau, CP
 
dc.contributor.authorTse, HF
 
dc.date.accessioned2012-09-05T05:32:43Z
 
dc.date.available2012-09-05T05:32:43Z
 
dc.date.issued2012
 
dc.description.abstractBackground: Left ventricular (LV) mechanical dyssynchrony can lead to impairment of LV function and is associated with adverse clinical outcomes in coronary artery disease (CAD) patients. The impact of LV dyssynchrony on exercise capacity (EC) in patients with CAD was investigated. Methods and Results: An echocardiographic examination with tissue Doppler imaging and exercise treadmill testing in 151 CAD patients with normal LV ejection fraction was performed. LV intra- and inter-ventricular dyssynchrony were defined by the standard deviation of time interval between LV 6 basal segments (Ts-SD), and the time interval from the right ventricular (RV) free wall to LV lateral wall (Ts-RV) respectively, and EC was measured as metabolic equivalents (METs) on the treadmill. Patients with impaired EC (defined by a METs ≤8, which is the mean MET of the study population) were older (71±7 vs. 62±2 years, P<0.01), however, there were no differences in gender and clinical status such as prevalence of prior myocardial infarction (MI), regional wall motion abnormality (RWMA), and coronary revascularization between patients with (n=90) or without (n=61) impaired EC. Univariate analysis showed that age, body mass index, LV systolic and diastolic volume, mitral inflow A velocity, and Ts-SD were all significantly associated with METs (all P<0.05). However, multivariate regression analysis revealed that old age (odd ratio [OR]: 1.136, 95% confidence interval [CI]: 1.080-1.196, P<0.001), and Ts-SD (OR: 1.026, 95%CI: 1.003-1.049, P=0.027) only were independent predictors for impaired EC. Conclusions: In patients with CAD, LV systolic dyssynchrony predicts impaired EC independently of history of previous MI or RWMA.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCirculation Journal, 2012, v. 76 n. 3, p. 682-688 [How to Cite?]
DOI: http://dx.doi.org/10.1253/circj.CJ-11-0735
 
dc.identifier.doihttp://dx.doi.org/10.1253/circj.CJ-11-0735
 
dc.identifier.epage688
 
dc.identifier.issn1346-9843
2012 Impact Factor: 3.578
2012 SCImago Journal Rankings: 1.337
 
dc.identifier.issue3
 
dc.identifier.pmid22240594
 
dc.identifier.scopuseid_2-s2.0-84863254532
 
dc.identifier.spage682
 
dc.identifier.urihttp://hdl.handle.net/10722/163506
 
dc.identifier.volume76
 
dc.languageeng
 
dc.publisherJapanese Circulation Society. The Journal's web site is located at http://www.j-circ.or.jp/english/publications/
 
dc.publisher.placeJapan
 
dc.relation.ispartofCirculation Journal
 
dc.relation.referencesReferences in Scopus
 
dc.subjectCoronary Artery Disease
 
dc.subjectExercise Capacity
 
dc.subjectLeft Ventricular Dyssynchrony
 
dc.subjectMyocardial Infarction
 
dc.subjectRegional Wall Motion Abnormality
 
dc.titleLeft ventricular mechanical dyssynchrony impairs exercise capacity in patients with coronary artery disease with preserved left ventricular systolic function and a QRS duration ≤120 ms
 
dc.typeArticle
 
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<contributor.author>Yue, WS</contributor.author>
<contributor.author>Siu, CW</contributor.author>
<contributor.author>Yiu, KH</contributor.author>
<contributor.author>Lee, SWL</contributor.author>
<contributor.author>Lau, CP</contributor.author>
<contributor.author>Tse, HF</contributor.author>
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<description.abstract>Background: Left ventricular (LV) mechanical dyssynchrony can lead to impairment of LV function and is associated with adverse clinical outcomes in coronary artery disease (CAD) patients. The impact of LV dyssynchrony on exercise capacity (EC) in patients with CAD was investigated. Methods and Results: An echocardiographic examination with tissue Doppler imaging and exercise treadmill testing in 151 CAD patients with normal LV ejection fraction was performed. LV intra- and inter-ventricular dyssynchrony were defined by the standard deviation of time interval between LV 6 basal segments (Ts-SD), and the time interval from the right ventricular (RV) free wall to LV lateral wall (Ts-RV) respectively, and EC was measured as metabolic equivalents (METs) on the treadmill. Patients with impaired EC (defined by a METs &#8804;8, which is the mean MET of the study population) were older (71&#177;7 vs. 62&#177;2 years, P&lt;0.01), however, there were no differences in gender and clinical status such as prevalence of prior myocardial infarction (MI), regional wall motion abnormality (RWMA), and coronary revascularization between patients with (n=90) or without (n=61) impaired EC. Univariate analysis showed that age, body mass index, LV systolic and diastolic volume, mitral inflow A velocity, and Ts-SD were all significantly associated with METs (all P&lt;0.05). However, multivariate regression analysis revealed that old age (odd ratio [OR]: 1.136, 95% confidence interval [CI]: 1.080-1.196, P&lt;0.001), and Ts-SD (OR: 1.026, 95%CI: 1.003-1.049, P=0.027) only were independent predictors for impaired EC. Conclusions: In patients with CAD, LV systolic dyssynchrony predicts impaired EC independently of history of previous MI or RWMA.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Queen Mary Hospital Hong Kong