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Article: Frequent premature atrial complexes predict new occurrence of atrial fibrillation and adverse cardiovascular events

TitleFrequent premature atrial complexes predict new occurrence of atrial fibrillation and adverse cardiovascular events
Authors
KeywordsAtrial Fibrillation And Stroke
Premature Atrial Complexes
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://europace.oxfordjournals.org/
Citation
Europace, 2012, v. 14 n. 7, p. 942-947 How to Cite?
Abstract
AimsTo investigate the relation between baseline frequency of premature atrial complexes (PACs) and new atrial fibrillation (AF) and adverse cardiovascular events.Method and resultsFour hundred and twenty-eight patients without AF or structural heart disease undergoing 24 h electrocardiography monitoring for palpitations, dizziness, or syncope were recruited. One hundred and seven patients with number of PACs at the top quartile (i.e. >100PACs/day) were defined to have frequent PACs. After 6.1-year follow-up, 31 patients (29) with frequent PACs developed AF compared with 29 patients (9) with PACs ≤100/day (P< 0.01). Cox regression analysis revealed that frequent PACs [hazard ratio (HR): 3.22 (95 confidence interval (CI): 1.95.5; P< 0.001)], age >75 years (HR: 2.3; 95 CI: 1.33.9; P 0.004), and coronary artery disease (HR: 2.5; 95 CI: 1.44.4; P 0.002) were independent predictors for new AF. Concerning the composite endpoint (ischaemic stroke, heart failure, and death), patients with frequent PACs were more at risk than those without (34.5 vs. 19.3) (HR: 1.95; 95 CI: 1.373.50; P 0.001). Cox regression analysis showed that age >75 years (HR: 2.2; 95 CI: 1.473.41; P< 0.001), coronary artery disease (HR: 2.2, 95 CI: 1.423.44, P< 0.001), and frequent PACs (HR: 1.6; 95 CI: 1.042.44; P 0.03) were independent predictors for the secondary composite endpoint.ConclusionFrequent PACs predict new AF and adverse cardiovascular events. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011.2011 © Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011.
Persistent Identifierhttp://hdl.handle.net/10722/163505
ISSN
2013 Impact Factor: 3.050
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChong, BHen_US
dc.contributor.authorPong, Ven_US
dc.contributor.authorLam, KFen_US
dc.contributor.authorLiu, Sen_US
dc.contributor.authorZuo, MLen_US
dc.contributor.authorLau, YFen_US
dc.contributor.authorLau, CPen_US
dc.contributor.authorTse, HFen_US
dc.contributor.authorSiu, CWen_US
dc.date.accessioned2012-09-05T05:32:41Z-
dc.date.available2012-09-05T05:32:41Z-
dc.date.issued2012en_US
dc.identifier.citationEuropace, 2012, v. 14 n. 7, p. 942-947en_US
dc.identifier.issn1099-5129en_US
dc.identifier.urihttp://hdl.handle.net/10722/163505-
dc.description.abstractAimsTo investigate the relation between baseline frequency of premature atrial complexes (PACs) and new atrial fibrillation (AF) and adverse cardiovascular events.Method and resultsFour hundred and twenty-eight patients without AF or structural heart disease undergoing 24 h electrocardiography monitoring for palpitations, dizziness, or syncope were recruited. One hundred and seven patients with number of PACs at the top quartile (i.e. >100PACs/day) were defined to have frequent PACs. After 6.1-year follow-up, 31 patients (29) with frequent PACs developed AF compared with 29 patients (9) with PACs ≤100/day (P< 0.01). Cox regression analysis revealed that frequent PACs [hazard ratio (HR): 3.22 (95 confidence interval (CI): 1.95.5; P< 0.001)], age >75 years (HR: 2.3; 95 CI: 1.33.9; P 0.004), and coronary artery disease (HR: 2.5; 95 CI: 1.44.4; P 0.002) were independent predictors for new AF. Concerning the composite endpoint (ischaemic stroke, heart failure, and death), patients with frequent PACs were more at risk than those without (34.5 vs. 19.3) (HR: 1.95; 95 CI: 1.373.50; P 0.001). Cox regression analysis showed that age >75 years (HR: 2.2; 95 CI: 1.473.41; P< 0.001), coronary artery disease (HR: 2.2, 95 CI: 1.423.44, P< 0.001), and frequent PACs (HR: 1.6; 95 CI: 1.042.44; P 0.03) were independent predictors for the secondary composite endpoint.ConclusionFrequent PACs predict new AF and adverse cardiovascular events. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011.2011 © Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://europace.oxfordjournals.org/en_US
dc.relation.ispartofEuropaceen_US
dc.subjectAtrial Fibrillation And Strokeen_US
dc.subjectPremature Atrial Complexesen_US
dc.titleFrequent premature atrial complexes predict new occurrence of atrial fibrillation and adverse cardiovascular eventsen_US
dc.typeArticleen_US
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_US
dc.identifier.authoritySiu, CW=rp00534en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1093/europace/eur389en_US
dc.identifier.pmid22183750-
dc.identifier.scopuseid_2-s2.0-84862979101en_US
dc.identifier.hkuros222724-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862979101&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue7en_US
dc.identifier.spage942en_US
dc.identifier.epage947en_US
dc.identifier.isiWOS:000305621000006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChong, BH=53263288800en_US
dc.identifier.scopusauthoridPong, V=26025247300en_US
dc.identifier.scopusauthoridLam, KF=55265945800en_US
dc.identifier.scopusauthoridLiu, S=55266582100en_US
dc.identifier.scopusauthoridZuo, ML=54958367700en_US
dc.identifier.scopusauthoridLau, YF=55266245900en_US
dc.identifier.scopusauthoridLau, CP=35275317200en_US
dc.identifier.scopusauthoridTse, HF=54886126900en_US
dc.identifier.scopusauthoridSiu, CW=7006550690en_US

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