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Article: Frequent premature atrial complexes predict new occurrence of atrial fibrillation and adverse cardiovascular events
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TitleFrequent premature atrial complexes predict new occurrence of atrial fibrillation and adverse cardiovascular events
 
AuthorsChong, BH2 1
Pong, V2 1
Lam, KF2
Liu, S2 1
Zuo, ML2 1
Lau, YF2 1
Lau, CP2 1
Tse, HF2 1
Siu, CW2 1
 
KeywordsAtrial Fibrillation And Stroke
Premature Atrial Complexes
 
Issue Date2012
 
PublisherOxford University Press. The Journal's web site is located at http://europace.oxfordjournals.org/
 
CitationEuropace, 2012, v. 14 n. 7, p. 942-947 [How to Cite?]
DOI: http://dx.doi.org/10.1093/europace/eur389
 
AbstractAimsTo investigate the relation between baseline frequency of premature atrial complexes (PACs) and new atrial fibrillation (AF) and adverse cardiovascular events.Method and resultsFour hundred and twenty-eight patients without AF or structural heart disease undergoing 24 h electrocardiography monitoring for palpitations, dizziness, or syncope were recruited. One hundred and seven patients with number of PACs at the top quartile (i.e. >100PACs/day) were defined to have frequent PACs. After 6.1-year follow-up, 31 patients (29) with frequent PACs developed AF compared with 29 patients (9) with PACs ≤100/day (P< 0.01). Cox regression analysis revealed that frequent PACs [hazard ratio (HR): 3.22 (95 confidence interval (CI): 1.95.5; P< 0.001)], age >75 years (HR: 2.3; 95 CI: 1.33.9; P 0.004), and coronary artery disease (HR: 2.5; 95 CI: 1.44.4; P 0.002) were independent predictors for new AF. Concerning the composite endpoint (ischaemic stroke, heart failure, and death), patients with frequent PACs were more at risk than those without (34.5 vs. 19.3) (HR: 1.95; 95 CI: 1.373.50; P 0.001). Cox regression analysis showed that age >75 years (HR: 2.2; 95 CI: 1.473.41; P< 0.001), coronary artery disease (HR: 2.2, 95 CI: 1.423.44, P< 0.001), and frequent PACs (HR: 1.6; 95 CI: 1.042.44; P 0.03) were independent predictors for the secondary composite endpoint.ConclusionFrequent PACs predict new AF and adverse cardiovascular events. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011.2011 © Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011.
 
ISSN1099-5129
2012 Impact Factor: 2.765
2012 SCImago Journal Rankings: 1.264
 
DOIhttp://dx.doi.org/10.1093/europace/eur389
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChong, BH
 
dc.contributor.authorPong, V
 
dc.contributor.authorLam, KF
 
dc.contributor.authorLiu, S
 
dc.contributor.authorZuo, ML
 
dc.contributor.authorLau, YF
 
dc.contributor.authorLau, CP
 
dc.contributor.authorTse, HF
 
dc.contributor.authorSiu, CW
 
dc.date.accessioned2012-09-05T05:32:41Z
 
dc.date.available2012-09-05T05:32:41Z
 
dc.date.issued2012
 
dc.description.abstractAimsTo investigate the relation between baseline frequency of premature atrial complexes (PACs) and new atrial fibrillation (AF) and adverse cardiovascular events.Method and resultsFour hundred and twenty-eight patients without AF or structural heart disease undergoing 24 h electrocardiography monitoring for palpitations, dizziness, or syncope were recruited. One hundred and seven patients with number of PACs at the top quartile (i.e. >100PACs/day) were defined to have frequent PACs. After 6.1-year follow-up, 31 patients (29) with frequent PACs developed AF compared with 29 patients (9) with PACs ≤100/day (P< 0.01). Cox regression analysis revealed that frequent PACs [hazard ratio (HR): 3.22 (95 confidence interval (CI): 1.95.5; P< 0.001)], age >75 years (HR: 2.3; 95 CI: 1.33.9; P 0.004), and coronary artery disease (HR: 2.5; 95 CI: 1.44.4; P 0.002) were independent predictors for new AF. Concerning the composite endpoint (ischaemic stroke, heart failure, and death), patients with frequent PACs were more at risk than those without (34.5 vs. 19.3) (HR: 1.95; 95 CI: 1.373.50; P 0.001). Cox regression analysis showed that age >75 years (HR: 2.2; 95 CI: 1.473.41; P< 0.001), coronary artery disease (HR: 2.2, 95 CI: 1.423.44, P< 0.001), and frequent PACs (HR: 1.6; 95 CI: 1.042.44; P 0.03) were independent predictors for the secondary composite endpoint.ConclusionFrequent PACs predict new AF and adverse cardiovascular events. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011.2011 © Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationEuropace, 2012, v. 14 n. 7, p. 942-947 [How to Cite?]
DOI: http://dx.doi.org/10.1093/europace/eur389
 
dc.identifier.doihttp://dx.doi.org/10.1093/europace/eur389
 
dc.identifier.epage947
 
dc.identifier.hkuros222724
 
dc.identifier.issn1099-5129
2012 Impact Factor: 2.765
2012 SCImago Journal Rankings: 1.264
 
dc.identifier.issue7
 
dc.identifier.pmid22183750
 
dc.identifier.scopuseid_2-s2.0-84862979101
 
dc.identifier.spage942
 
dc.identifier.urihttp://hdl.handle.net/10722/163505
 
dc.identifier.volume14
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://europace.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofEuropace
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAtrial Fibrillation And Stroke
 
dc.subjectPremature Atrial Complexes
 
dc.titleFrequent premature atrial complexes predict new occurrence of atrial fibrillation and adverse cardiovascular events
 
dc.typeArticle
 
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<contributor.author>Pong, V</contributor.author>
<contributor.author>Lam, KF</contributor.author>
<contributor.author>Liu, S</contributor.author>
<contributor.author>Zuo, ML</contributor.author>
<contributor.author>Lau, YF</contributor.author>
<contributor.author>Lau, CP</contributor.author>
<contributor.author>Tse, HF</contributor.author>
<contributor.author>Siu, CW</contributor.author>
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<description.abstract>AimsTo investigate the relation between baseline frequency of premature atrial complexes (PACs) and new atrial fibrillation (AF) and adverse cardiovascular events.Method and resultsFour hundred and twenty-eight patients without AF or structural heart disease undergoing 24 h electrocardiography monitoring for palpitations, dizziness, or syncope were recruited. One hundred and seven patients with number of PACs at the top quartile (i.e. &gt;100PACs/day) were defined to have frequent PACs. After 6.1-year follow-up, 31 patients (29) with frequent PACs developed AF compared with 29 patients (9) with PACs &#8804;100/day (P&lt; 0.01). Cox regression analysis revealed that frequent PACs [hazard ratio (HR): 3.22 (95 confidence interval (CI): 1.95.5; P&lt; 0.001)], age &gt;75 years (HR: 2.3; 95 CI: 1.33.9; P 0.004), and coronary artery disease (HR: 2.5; 95 CI: 1.44.4; P 0.002) were independent predictors for new AF. Concerning the composite endpoint (ischaemic stroke, heart failure, and death), patients with frequent PACs were more at risk than those without (34.5 vs. 19.3) (HR: 1.95; 95 CI: 1.373.50; P 0.001). Cox regression analysis showed that age &gt;75 years (HR: 2.2; 95 CI: 1.473.41; P&lt; 0.001), coronary artery disease (HR: 2.2, 95 CI: 1.423.44, P&lt; 0.001), and frequent PACs (HR: 1.6; 95 CI: 1.042.44; P 0.03) were independent predictors for the secondary composite endpoint.ConclusionFrequent PACs predict new AF and adverse cardiovascular events. Published on behalf of the European Society of Cardiology. All rights reserved. &#169; The Author 2011.2011 &#169; Published on behalf of the European Society of Cardiology. All rights reserved. &#169; The Author 2011.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong