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Article: Subclinical left ventricular dysfunction revealed by circumferential 2D strain imaging in patients with coronary artery disease and fragmented QRS complex

TitleSubclinical left ventricular dysfunction revealed by circumferential 2D strain imaging in patients with coronary artery disease and fragmented QRS complex
Authors
KeywordsCoronary Artery Disease
Fragmented Qrs
Strain
Strain Rate
Issue Date2012
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/heartrhythmjournal
Citation
Heart Rhythm, 2012, v. 9 n. 6, p. 928-935 How to Cite?
AbstractBackground: Fragmented QRS (fQRS) complexes on a routine 12-lead electrocardiogram were associated with adverse cardiac events, including sudden death in patients with coronary artery disease (CAD). Objective: To investigate the relationship between the fQRS complex and global and regional left ventricular (LV) functions in patients with CAD. Methods: The study consisted of 176 patients (68 ± 9 years; 145 [82%] men) with CAD with narrow QRS duration and preserved LV ejection fraction (>45%). All patients underwent detailed 2-dimensional speckle-tracking echocardiography to determine global and segmental (basal, middle, and apical) LV strains and strain rates and were prospectively followed-up in the outpatient clinic. Results: Fifty-five patients (31%) had fQRS complexes. Global, middle, and apical LV longitudinal, radial, and circumferential strains and strain rates were significantly lower in the fQRS group than in the non-fQRS group (all P <.05). Multivariate logistic regression analysis revealed that the fQRS complex was associated with decreased global circumferential strain (odds ratio 1.19; 95% confidence interval 1.06-1.33; P =.003) and multivessel disease (odds ratio 3.69; 95% confidence interval 1.35-10.08; P =.011). Kaplan-Meier analysis revealed that event-free survival for cardiac events was significantly lower in the fQRS group than in the non-fQRS group (P =.036). Conclusions: Our results demonstrated that the fQRS complex in patients with CAD with preserved LV ejection fraction was associated with subclinical global and regional LV dysfunctions as detected by 2-dimensional speckle-tracking imaging, and the results also predicted adverse cardiac events. © 2012 Heart Rhythm Society. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163501
ISSN
2014 Impact Factor: 5.076
2014 SCImago Journal Rankings: 2.612
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYan, GHen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorYiu, KHen_US
dc.contributor.authorLau, CPen_US
dc.contributor.authorZhi, Gen_US
dc.contributor.authorLee, SWLen_US
dc.contributor.authorSiu, CWen_US
dc.contributor.authorTse, HFen_US
dc.date.accessioned2012-09-05T05:32:24Z-
dc.date.available2012-09-05T05:32:24Z-
dc.date.issued2012en_US
dc.identifier.citationHeart Rhythm, 2012, v. 9 n. 6, p. 928-935en_US
dc.identifier.issn1547-5271en_US
dc.identifier.urihttp://hdl.handle.net/10722/163501-
dc.description.abstractBackground: Fragmented QRS (fQRS) complexes on a routine 12-lead electrocardiogram were associated with adverse cardiac events, including sudden death in patients with coronary artery disease (CAD). Objective: To investigate the relationship between the fQRS complex and global and regional left ventricular (LV) functions in patients with CAD. Methods: The study consisted of 176 patients (68 ± 9 years; 145 [82%] men) with CAD with narrow QRS duration and preserved LV ejection fraction (>45%). All patients underwent detailed 2-dimensional speckle-tracking echocardiography to determine global and segmental (basal, middle, and apical) LV strains and strain rates and were prospectively followed-up in the outpatient clinic. Results: Fifty-five patients (31%) had fQRS complexes. Global, middle, and apical LV longitudinal, radial, and circumferential strains and strain rates were significantly lower in the fQRS group than in the non-fQRS group (all P <.05). Multivariate logistic regression analysis revealed that the fQRS complex was associated with decreased global circumferential strain (odds ratio 1.19; 95% confidence interval 1.06-1.33; P =.003) and multivessel disease (odds ratio 3.69; 95% confidence interval 1.35-10.08; P =.011). Kaplan-Meier analysis revealed that event-free survival for cardiac events was significantly lower in the fQRS group than in the non-fQRS group (P =.036). Conclusions: Our results demonstrated that the fQRS complex in patients with CAD with preserved LV ejection fraction was associated with subclinical global and regional LV dysfunctions as detected by 2-dimensional speckle-tracking imaging, and the results also predicted adverse cardiac events. © 2012 Heart Rhythm Society. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/heartrhythmjournalen_US
dc.relation.ispartofHeart Rhythmen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectFragmented Qrsen_US
dc.subjectStrainen_US
dc.subjectStrain Rateen_US
dc.titleSubclinical left ventricular dysfunction revealed by circumferential 2D strain imaging in patients with coronary artery disease and fragmented QRS complexen_US
dc.typeArticleen_US
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_US
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_US
dc.identifier.authoritySiu, CW=rp00534en_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.hrthm.2012.01.007en_US
dc.identifier.pmid22245798-
dc.identifier.scopuseid_2-s2.0-84862777690en_US
dc.identifier.hkuros218478-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862777690&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume9en_US
dc.identifier.issue6en_US
dc.identifier.spage928en_US
dc.identifier.epage935en_US
dc.identifier.isiWOS:000304242900019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYan, GH=36544693600en_US
dc.identifier.scopusauthoridWang, M=55032544200en_US
dc.identifier.scopusauthoridYiu, KH=55035807600en_US
dc.identifier.scopusauthoridLau, CP=35275317200en_US
dc.identifier.scopusauthoridZhi, G=7003672763en_US
dc.identifier.scopusauthoridLee, SWL=7601396808en_US
dc.identifier.scopusauthoridSiu, CW=7006550690en_US
dc.identifier.scopusauthoridTse, HF=7006070805en_US

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