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Article: Type II enteropathy-associated T-cell lymphoma: a multicenter analysis from the Asia Lymphoma Study Group

TitleType II enteropathy-associated T-cell lymphoma: a multicenter analysis from the Asia Lymphoma Study Group
Authors
KeywordsCD3 antigen
CD4 antigen
CD56 antigen
CD8 antigen
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35105
Citation
American Journal of Hematology, 2012, v. 87 n. 7, p. 663-668 How to Cite?
AbstractEnteropathy-associated T-cell lymphoma (EATL) is a rare primary gastrointestinal T-cell lymphoma. A multicenter study from the Asia Lymphoma Study Group identified 38 EATL patients within a 19-year period. All cases were type II EATL. Men were affected twice as common as women, at a median age of 59 (23-89) years. None had a history of celiac disease. The sites of involvement were small bowel and stomach (5%), small bowel (63%), small and large bowel (16%), and large bowel (18%). Common presenting features were bowel perforation (34%), pain (32%), and obstruction (21%). Lymphomas showed monomorphic neoplastic lymphoid infiltrates that were CD3(+) (100%), CD56(+) (91%), TIA-1(+) (96%), CD4(-)CD8(+) (63%), CD4(+)CD8(+) (19%), CD4(-)CD8(-) (16%), and CD4(+)CD8(-) (3%). Epstein Barr virus was demonstrable in three cases. Despite chemotherapy and/or surgical resection, the overall response and complete response rates were poor at 46% and 38%. The median overall survival (OS) was 7 months and progression-free-survival (PFS) 1 month. Five patients underwent hematopoietic stem cell transplantation all were alive. Age and the prognostic index for peripheral T-cell lymphoma were not prognostically significant. Good performance status was associated with better OS (P = 0.03), and response to initial treatment led to better OS and PFS (P < 0.001). © 2012 Wiley Periodicals, Inc.
DescriptionResearch article
Persistent Identifierhttp://hdl.handle.net/10722/163499
ISSN
2015 Impact Factor: 5.0
2015 SCImago Journal Rankings: 1.761
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, Een_US
dc.contributor.authorGill, Hen_US
dc.contributor.authorLoong, Fen_US
dc.contributor.authorKim, SJen_US
dc.contributor.authorNG, SBen_US
dc.contributor.authorTang, Ten_US
dc.contributor.authorKo, YHen_US
dc.contributor.authorChng, WJen_US
dc.contributor.authorLim, STen_US
dc.contributor.authorKim, WSen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:32:21Z-
dc.date.available2012-09-05T05:32:21Z-
dc.date.issued2012en_US
dc.identifier.citationAmerican Journal of Hematology, 2012, v. 87 n. 7, p. 663-668en_US
dc.identifier.issn0361-8609en_US
dc.identifier.urihttp://hdl.handle.net/10722/163499-
dc.descriptionResearch article-
dc.description.abstractEnteropathy-associated T-cell lymphoma (EATL) is a rare primary gastrointestinal T-cell lymphoma. A multicenter study from the Asia Lymphoma Study Group identified 38 EATL patients within a 19-year period. All cases were type II EATL. Men were affected twice as common as women, at a median age of 59 (23-89) years. None had a history of celiac disease. The sites of involvement were small bowel and stomach (5%), small bowel (63%), small and large bowel (16%), and large bowel (18%). Common presenting features were bowel perforation (34%), pain (32%), and obstruction (21%). Lymphomas showed monomorphic neoplastic lymphoid infiltrates that were CD3(+) (100%), CD56(+) (91%), TIA-1(+) (96%), CD4(-)CD8(+) (63%), CD4(+)CD8(+) (19%), CD4(-)CD8(-) (16%), and CD4(+)CD8(-) (3%). Epstein Barr virus was demonstrable in three cases. Despite chemotherapy and/or surgical resection, the overall response and complete response rates were poor at 46% and 38%. The median overall survival (OS) was 7 months and progression-free-survival (PFS) 1 month. Five patients underwent hematopoietic stem cell transplantation all were alive. Age and the prognostic index for peripheral T-cell lymphoma were not prognostically significant. Good performance status was associated with better OS (P = 0.03), and response to initial treatment led to better OS and PFS (P < 0.001). © 2012 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35105en_US
dc.relation.ispartofAmerican Journal of Hematologyen_US
dc.rightsAmerican Journal of Hematology. Copyright © John Wiley & Sons, Inc.-
dc.subjectCD3 antigen-
dc.subjectCD4 antigen-
dc.subjectCD56 antigen-
dc.subjectCD8 antigen-
dc.subject.meshAbdominal Pain - etiology-
dc.subject.meshEnteropathy-sssociated T-cell lymphoma - immunology - pathology - physiopathology - therapy-
dc.subject.meshGastrointestinal neoplasms - immunology - pathology - physiopathology - therapy-
dc.subject.meshIntestinal obstruction - etiology-
dc.subject.meshIntestinal perforation - etiology-
dc.titleType II enteropathy-associated T-cell lymphoma: a multicenter analysis from the Asia Lymphoma Study Groupen_US
dc.typeArticleen_US
dc.identifier.emailTse, E: ewctse@hku.hken_US
dc.identifier.emailLoong, F: floong@hkucc.hku.hk-
dc.identifier.emailKwong, YL: ylkwong@hku.hk-
dc.identifier.authorityTse, E=rp00471en_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajh.23213en_US
dc.identifier.pmid22641357-
dc.identifier.scopuseid_2-s2.0-84862568154en_US
dc.identifier.hkuros207882-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862568154&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume87en_US
dc.identifier.issue7en_US
dc.identifier.spage663en_US
dc.identifier.epage668en_US
dc.identifier.isiWOS:000305209700004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridKim, WS=34975082200en_US
dc.identifier.scopusauthoridLim, ST=8653861000en_US
dc.identifier.scopusauthoridChng, WJ=8717348700en_US
dc.identifier.scopusauthoridKo, YH=16646069600en_US
dc.identifier.scopusauthoridTang, T=35485910800en_US
dc.identifier.scopusauthoridNg, SB=7403358752en_US
dc.identifier.scopusauthoridKim, SJ=8702924000en_US
dc.identifier.scopusauthoridLoong, F=6602794154en_US
dc.identifier.scopusauthoridGill, H=36086184900en_US
dc.identifier.scopusauthoridTse, E=55227599500en_US

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