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Article: Gene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned

TitleGene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned
Authors
KeywordsBio-Artificial
Cardiac Differentiation
Electrophysiology
Human Embryonic Stem Cells
Pacemaker
Pluripotent
Issue Date2012
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gt
Citation
Gene Therapy, 2012, v. 19 n. 6, p. 588-595 How to Cite?
AbstractNormal rhythms originate in the sino-atrial node, a specialized cardiac tissue consisting of only a few thousands of nodal pacemaker cells. Malfunction of pacemaker cells due to diseases or aging leads to rhythm generation disorders (for example, bradycardias and sick-sinus syndrome (SSS)), which often necessitate the implantation of electronic pacemakers. Although effective, electronic devices are associated with such shortcomings as limited battery life, permanent implantation of leads, lead dislodging, the lack of autonomic responses and so on. Here, various gene-and cell-based approaches, with a particular emphasis placed on the use of pluripotent stem cells and the hyperpolarization-activated cyclic nucleotide-gated-encoded pacemaker gene family, that have been pursued in the past decade to reconstruct bio-artificial pacemakers as alternatives will be discussed in relation to the basic biological insights and translational regenerative potential. © 2012 Macmillan Publishers Limited All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163497
ISSN
2015 Impact Factor: 3.242
2015 SCImago Journal Rankings: 1.519
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, RAen_US
dc.date.accessioned2012-09-05T05:32:19Z-
dc.date.available2012-09-05T05:32:19Z-
dc.date.issued2012en_US
dc.identifier.citationGene Therapy, 2012, v. 19 n. 6, p. 588-595en_US
dc.identifier.issn0969-7128en_US
dc.identifier.urihttp://hdl.handle.net/10722/163497-
dc.description.abstractNormal rhythms originate in the sino-atrial node, a specialized cardiac tissue consisting of only a few thousands of nodal pacemaker cells. Malfunction of pacemaker cells due to diseases or aging leads to rhythm generation disorders (for example, bradycardias and sick-sinus syndrome (SSS)), which often necessitate the implantation of electronic pacemakers. Although effective, electronic devices are associated with such shortcomings as limited battery life, permanent implantation of leads, lead dislodging, the lack of autonomic responses and so on. Here, various gene-and cell-based approaches, with a particular emphasis placed on the use of pluripotent stem cells and the hyperpolarization-activated cyclic nucleotide-gated-encoded pacemaker gene family, that have been pursued in the past decade to reconstruct bio-artificial pacemakers as alternatives will be discussed in relation to the basic biological insights and translational regenerative potential. © 2012 Macmillan Publishers Limited All rights reserved.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gten_US
dc.relation.ispartofGene Therapyen_US
dc.subjectBio-Artificialen_US
dc.subjectCardiac Differentiationen_US
dc.subjectElectrophysiologyen_US
dc.subjectHuman Embryonic Stem Cellsen_US
dc.subjectPacemakeren_US
dc.subjectPluripotenten_US
dc.titleGene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learneden_US
dc.typeArticleen_US
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hken_US
dc.identifier.authorityLi, RA=rp01352en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1038/gt.2012.33en_US
dc.identifier.pmid22673497-
dc.identifier.pmcidPMC3375623-
dc.identifier.scopuseid_2-s2.0-84862020324en_US
dc.identifier.hkuros212191-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862020324&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue6en_US
dc.identifier.spage588en_US
dc.identifier.epage595en_US
dc.identifier.isiWOS:000305081600002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLi, RA=7404724466en_US
dc.customcontrol.immutablesml 140917-

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