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- Publisher Website: 10.1038/gt.2012.33
- Scopus: eid_2-s2.0-84862020324
- PMID: 22673497
- WOS: WOS:000305081600002
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Article: Gene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned
Title | Gene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned |
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Authors | |
Keywords | Bio-Artificial Cardiac Differentiation Electrophysiology Human Embryonic Stem Cells Pacemaker Pluripotent |
Issue Date | 2012 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/gt |
Citation | Gene Therapy, 2012, v. 19 n. 6, p. 588-595 How to Cite? |
Abstract | Normal rhythms originate in the sino-atrial node, a specialized cardiac tissue consisting of only a few thousands of nodal pacemaker cells. Malfunction of pacemaker cells due to diseases or aging leads to rhythm generation disorders (for example, bradycardias and sick-sinus syndrome (SSS)), which often necessitate the implantation of electronic pacemakers. Although effective, electronic devices are associated with such shortcomings as limited battery life, permanent implantation of leads, lead dislodging, the lack of autonomic responses and so on. Here, various gene-and cell-based approaches, with a particular emphasis placed on the use of pluripotent stem cells and the hyperpolarization-activated cyclic nucleotide-gated-encoded pacemaker gene family, that have been pursued in the past decade to reconstruct bio-artificial pacemakers as alternatives will be discussed in relation to the basic biological insights and translational regenerative potential. © 2012 Macmillan Publishers Limited All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/163497 |
ISSN | 2023 Impact Factor: 4.6 2023 SCImago Journal Rankings: 1.671 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Li, RA | en_US |
dc.date.accessioned | 2012-09-05T05:32:19Z | - |
dc.date.available | 2012-09-05T05:32:19Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Gene Therapy, 2012, v. 19 n. 6, p. 588-595 | en_US |
dc.identifier.issn | 0969-7128 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163497 | - |
dc.description.abstract | Normal rhythms originate in the sino-atrial node, a specialized cardiac tissue consisting of only a few thousands of nodal pacemaker cells. Malfunction of pacemaker cells due to diseases or aging leads to rhythm generation disorders (for example, bradycardias and sick-sinus syndrome (SSS)), which often necessitate the implantation of electronic pacemakers. Although effective, electronic devices are associated with such shortcomings as limited battery life, permanent implantation of leads, lead dislodging, the lack of autonomic responses and so on. Here, various gene-and cell-based approaches, with a particular emphasis placed on the use of pluripotent stem cells and the hyperpolarization-activated cyclic nucleotide-gated-encoded pacemaker gene family, that have been pursued in the past decade to reconstruct bio-artificial pacemakers as alternatives will be discussed in relation to the basic biological insights and translational regenerative potential. © 2012 Macmillan Publishers Limited All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/gt | en_US |
dc.relation.ispartof | Gene Therapy | en_US |
dc.subject | Bio-Artificial | en_US |
dc.subject | Cardiac Differentiation | en_US |
dc.subject | Electrophysiology | en_US |
dc.subject | Human Embryonic Stem Cells | en_US |
dc.subject | Pacemaker | en_US |
dc.subject | Pluripotent | en_US |
dc.title | Gene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, RA: ronaldli@hkucc.hku.hk | en_US |
dc.identifier.authority | Li, RA=rp01352 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1038/gt.2012.33 | en_US |
dc.identifier.pmid | 22673497 | - |
dc.identifier.pmcid | PMC3375623 | - |
dc.identifier.scopus | eid_2-s2.0-84862020324 | en_US |
dc.identifier.hkuros | 212191 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84862020324&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 588 | en_US |
dc.identifier.epage | 595 | en_US |
dc.identifier.isi | WOS:000305081600002 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Li, RA=7404724466 | en_US |
dc.customcontrol.immutable | sml 140917 | - |
dc.identifier.issnl | 0969-7128 | - |