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Article: OSA and atherosclerosis

TitleOSA and atherosclerosis
Authors
Issue Date2012
PublisherPioneer Bioscience Publishing Company. The Journal's web site is located at http://www.jthoracdis.com/
Citation
Journal Of Thoracic Disease, 2012, v. 4 n. 2, p. 164-172 How to Cite?
Abstract
Untreated obstructive sleep apnea (OSA) is increasingly recognized as a risk factor contributing to cardiovascular morbidity and mortality. Research in recent decades has uncovered many components of the complex pathological events leading to the atherosclerotic vascular diseases in OSA, which involve heightened oxidative stress as a result of intermittent hypoxia, vascular inflammation, activation of platelet and coagulation cascades, endothelial dysfunction and ultimately the formation of atherosclerotic plagues. The close association of OSA and conventional cardiovascular risk factors including hypertension, diabetes mellitus, dyslipidemia and obesity adds to the adverse cardiovascular sequelae. Further studies are required to clarify further on the pathophysiological processes, and the effect size of OSA therapy, and other potential preventive strategies.
Persistent Identifierhttp://hdl.handle.net/10722/163495
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLui, MMSen_US
dc.contributor.authorIp, MSMen_US
dc.date.accessioned2012-09-05T05:32:18Z-
dc.date.available2012-09-05T05:32:18Z-
dc.date.issued2012en_US
dc.identifier.citationJournal Of Thoracic Disease, 2012, v. 4 n. 2, p. 164-172en_US
dc.identifier.issn2072-1439en_US
dc.identifier.urihttp://hdl.handle.net/10722/163495-
dc.description.abstractUntreated obstructive sleep apnea (OSA) is increasingly recognized as a risk factor contributing to cardiovascular morbidity and mortality. Research in recent decades has uncovered many components of the complex pathological events leading to the atherosclerotic vascular diseases in OSA, which involve heightened oxidative stress as a result of intermittent hypoxia, vascular inflammation, activation of platelet and coagulation cascades, endothelial dysfunction and ultimately the formation of atherosclerotic plagues. The close association of OSA and conventional cardiovascular risk factors including hypertension, diabetes mellitus, dyslipidemia and obesity adds to the adverse cardiovascular sequelae. Further studies are required to clarify further on the pathophysiological processes, and the effect size of OSA therapy, and other potential preventive strategies.en_US
dc.languageengen_US
dc.publisherPioneer Bioscience Publishing Company. The Journal's web site is located at http://www.jthoracdis.com/-
dc.relation.ispartofJournal of Thoracic Diseaseen_US
dc.titleOSA and atherosclerosisen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3978/j.issn.2072-1439.2012.01.06en_US
dc.identifier.pmid22833822-
dc.identifier.scopuseid_2-s2.0-84861985896en_US
dc.identifier.hkuros207018-
dc.identifier.volume4en_US
dc.identifier.issue2en_US
dc.identifier.spage164en_US
dc.identifier.epage172en_US
dc.identifier.isiWOS:000314789900011-
dc.publisher.placeHong Kong-

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