Article: OSA and atherosclerosis
| Title | OSA and atherosclerosis |
|---|---|
| Authors | Lui, MMS1 Ip, MSM |
| Issue Date | 2012 |
| Publisher | Pioneer Bioscience Publishing Company. The Journal's web site is located at http://www.jthoracdis.com/ |
| Citation | Journal Of Thoracic Disease, 2012, v. 4 n. 2, p. 164-172 [How to Cite?] DOI: http://dx.doi.org/10.3978/j.issn.2072-1439.2012.01.06 |
| Abstract | Untreated obstructive sleep apnea (OSA) is increasingly recognized as a risk factor contributing to cardiovascular morbidity and mortality. Research in recent decades has uncovered many components of the complex pathological events leading to the atherosclerotic vascular diseases in OSA, which involve heightened oxidative stress as a result of intermittent hypoxia, vascular inflammation, activation of platelet and coagulation cascades, endothelial dysfunction and ultimately the formation of atherosclerotic plagues. The close association of OSA and conventional cardiovascular risk factors including hypertension, diabetes mellitus, dyslipidemia and obesity adds to the adverse cardiovascular sequelae. Further studies are required to clarify further on the pathophysiological processes, and the effect size of OSA therapy, and other potential preventive strategies. |
| ISSN | 2072-1439 |
| DOI | http://dx.doi.org/10.3978/j.issn.2072-1439.2012.01.06 |
| dc.contributor.author | Lui, MMS |
|---|---|
| dc.contributor.author | Ip, MSM |
| dc.date.accessioned | 2012-09-05T05:32:18Z |
| dc.date.available | 2012-09-05T05:32:18Z |
| dc.date.issued | 2012 |
| dc.description.abstract | Untreated obstructive sleep apnea (OSA) is increasingly recognized as a risk factor contributing to cardiovascular morbidity and mortality. Research in recent decades has uncovered many components of the complex pathological events leading to the atherosclerotic vascular diseases in OSA, which involve heightened oxidative stress as a result of intermittent hypoxia, vascular inflammation, activation of platelet and coagulation cascades, endothelial dysfunction and ultimately the formation of atherosclerotic plagues. The close association of OSA and conventional cardiovascular risk factors including hypertension, diabetes mellitus, dyslipidemia and obesity adds to the adverse cardiovascular sequelae. Further studies are required to clarify further on the pathophysiological processes, and the effect size of OSA therapy, and other potential preventive strategies. |
| dc.description.nature | Link_to_subscribed_fulltext |
| dc.identifier.citation | Journal Of Thoracic Disease, 2012, v. 4 n. 2, p. 164-172 [How to Cite?] DOI: http://dx.doi.org/10.3978/j.issn.2072-1439.2012.01.06 |
| dc.identifier.doi | http://dx.doi.org/10.3978/j.issn.2072-1439.2012.01.06 |
| dc.identifier.epage | 172 |
| dc.identifier.hkuros | 207018 |
| dc.identifier.issn | 2072-1439 |
| dc.identifier.issue | 2 |
| dc.identifier.scopus | eid_2-s2.0-84861985896 |
| dc.identifier.spage | 164 |
| dc.identifier.uri | http://hdl.handle.net/10722/163495 |
| dc.identifier.volume | 4 |
| dc.language | eng |
| dc.publisher | Pioneer Bioscience Publishing Company. The Journal's web site is located at http://www.jthoracdis.com/ |
| dc.publisher.place | Hong Kong |
| dc.relation.ispartof | Journal of Thoracic Disease |
| dc.title | OSA and atherosclerosis |
| dc.type | Article |
Author Affiliations
- The University of Hong Kong