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Article: Thoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure

TitleThoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failure
Authors
KeywordsHeart Failure
Ischemic Cardiomyopathy
Myocardial Infarction
Pacing
Spinal Cord Stimulation
Issue Date2012
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873
Citation
Journal Of Cardiovascular Electrophysiology, 2012, v. 23 n. 5, p. 534-540 How to Cite?
AbstractThoracic Spinal Cord Stimulation. Background: Prior experimental studies show that thoracic spinal cord stimulation (SCS) improves left ventricular (LV) ejection fraction (LVEF). The mechanism of this improvement in the LV contractile function after SCS and its effects on the myocardial oxygen consumption remains unknown. Methods and Results: We performed thoracic SCS (T1-T2 level) followed by 4 weeks of rapid ventricular pacing in 9 adult pigs with ischemic heart failure (HF) induced by myocardial infarction (MI). At 24 hours off-pacing, detailed echocardiogram and invasive hemodynamic assessment were performed to determine LV contractile function and myocardial oxygen consumption. Serum norepinephrine level was measured before and after SCS. SCS was performed on 2 occasions for 15 minutes, 30 minutes apart (recovery) with 50 Hz frequency (pulse width 0.2 millisecond, 90% of motor threshold at 2 Hz output). Echocardiogram revealed significant decrease in LVEF (33.8 ± 1.8% vs 66.5 ± 1.7%, P < 0.01) after induction of MI and HF. Compared with MI and HF, acute SCS significantly increased LVEF and +dP/dt (all P < 0.05). Withdrawal of SCS during recovery decreased +dP/dt, but not LVEF that increased again with repeated SCS. Myocardial oxygen consumption also significantly decreased during SCS compared with MI and HF (P = 0.006) without any change in serum norepinephrine level (P = 0.9). Speckle tracking imaging showed significant improvement in global and regional circumferential strains over the infarcted mid and apical regions, decreased in time to peak circumferential strain over the lateral and posterior wall after SCS, and the degree of intraventricular dyssynchrony during SCS compared with MI and HF (P < 0.05). Conclusions: In a porcine model of ischemic HF, acute SCS improved global and regional LV contractile function and intraventricular dyssynchrony, and decreased myocardial oxygen consumption without elevation of norepinephrine level. © 2011 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/163489
ISSN
2014 Impact Factor: 2.958
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Yen_US
dc.contributor.authorYue, WSen_US
dc.contributor.authorLiao, SYen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorAu, KWen_US
dc.contributor.authorShuto, Cen_US
dc.contributor.authorHata, Cen_US
dc.contributor.authorPark, Een_US
dc.contributor.authorChen, Pen_US
dc.contributor.authorSiu, CWen_US
dc.contributor.authorTse, HFen_US
dc.date.accessioned2012-09-05T05:32:06Z-
dc.date.available2012-09-05T05:32:06Z-
dc.date.issued2012en_US
dc.identifier.citationJournal Of Cardiovascular Electrophysiology, 2012, v. 23 n. 5, p. 534-540en_US
dc.identifier.issn1045-3873en_US
dc.identifier.urihttp://hdl.handle.net/10722/163489-
dc.description.abstractThoracic Spinal Cord Stimulation. Background: Prior experimental studies show that thoracic spinal cord stimulation (SCS) improves left ventricular (LV) ejection fraction (LVEF). The mechanism of this improvement in the LV contractile function after SCS and its effects on the myocardial oxygen consumption remains unknown. Methods and Results: We performed thoracic SCS (T1-T2 level) followed by 4 weeks of rapid ventricular pacing in 9 adult pigs with ischemic heart failure (HF) induced by myocardial infarction (MI). At 24 hours off-pacing, detailed echocardiogram and invasive hemodynamic assessment were performed to determine LV contractile function and myocardial oxygen consumption. Serum norepinephrine level was measured before and after SCS. SCS was performed on 2 occasions for 15 minutes, 30 minutes apart (recovery) with 50 Hz frequency (pulse width 0.2 millisecond, 90% of motor threshold at 2 Hz output). Echocardiogram revealed significant decrease in LVEF (33.8 ± 1.8% vs 66.5 ± 1.7%, P < 0.01) after induction of MI and HF. Compared with MI and HF, acute SCS significantly increased LVEF and +dP/dt (all P < 0.05). Withdrawal of SCS during recovery decreased +dP/dt, but not LVEF that increased again with repeated SCS. Myocardial oxygen consumption also significantly decreased during SCS compared with MI and HF (P = 0.006) without any change in serum norepinephrine level (P = 0.9). Speckle tracking imaging showed significant improvement in global and regional circumferential strains over the infarcted mid and apical regions, decreased in time to peak circumferential strain over the lateral and posterior wall after SCS, and the degree of intraventricular dyssynchrony during SCS compared with MI and HF (P < 0.05). Conclusions: In a porcine model of ischemic HF, acute SCS improved global and regional LV contractile function and intraventricular dyssynchrony, and decreased myocardial oxygen consumption without elevation of norepinephrine level. © 2011 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873en_US
dc.relation.ispartofJournal of Cardiovascular Electrophysiologyen_US
dc.subjectHeart Failureen_US
dc.subjectIschemic Cardiomyopathyen_US
dc.subjectMyocardial Infarctionen_US
dc.subjectPacingen_US
dc.subjectSpinal Cord Stimulationen_US
dc.titleThoracic spinal cord stimulation improves cardiac contractile function and myocardial oxygen consumption in a porcine model of ischemic heart failureen_US
dc.typeArticleen_US
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_US
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_US
dc.identifier.authoritySiu, CW=rp00534en_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1540-8167.2011.02230.xen_US
dc.identifier.pmid22151312-
dc.identifier.scopuseid_2-s2.0-84860840461en_US
dc.identifier.hkuros205027-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860840461&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue5en_US
dc.identifier.spage534en_US
dc.identifier.epage540en_US
dc.identifier.isiWOS:000303662100014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiu, Y=36071722500en_US
dc.identifier.scopusauthoridYue, WS=36106565300en_US
dc.identifier.scopusauthoridLiao, SY=22433820700en_US
dc.identifier.scopusauthoridZhang, Y=35785466900en_US
dc.identifier.scopusauthoridAu, KW=9738204200en_US
dc.identifier.scopusauthoridShuto, C=54421148500en_US
dc.identifier.scopusauthoridHata, C=36952633300en_US
dc.identifier.scopusauthoridPark, E=7402224798en_US
dc.identifier.scopusauthoridChen, P=54419581500en_US
dc.identifier.scopusauthoridSiu, CW=7006550690en_US
dc.identifier.scopusauthoridTse, HF=7006070805en_US

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