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Article: Pluripotent stem cell-based heart regeneration: From the developmental and immunological perspectives

TitlePluripotent stem cell-based heart regeneration: From the developmental and immunological perspectives
Authors
KeywordsEsc
Heart Development
Immunogenicity
Ipsc
Regenerative Medicine
Stem Cells
Transplantation
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/102527247
Citation
Birth Defects Research Part C - Embryo Today: Reviews, 2012, v. 96 n. 1, p. 98-108 How to Cite?
AbstractHeart diseases such as myocardial infarction cause massive loss of cardiomyocytes, but the human heart lacks the innate ability to regenerate. In the adult mammalian heart, a resident progenitor cell population, termed epicardial progenitors, has been identified and reported to stay quiescent under uninjured conditions; however, myocardial infarction induces their proliferation and de novo differentiation into cardiac cells. It is conceivable to develop novel therapeutic approaches for myocardial repair by targeting such expandable sources of cardiac progenitors, thereby giving rise to new muscle and vasculatures. Human pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells can self-renew and differentiate into the three major cell types of the heart, namely cardiomyocytes, smooth muscle, and endothelial cells. In this review, we describe our current knowledge of the therapeutic potential and challenges associated with the use of pluripotent stem cell and progenitor biology in cell therapy. An emphasis is placed on the contribution of paracrine factors in the growth of myocardium and neovascularization as well as the role of immunogenicity in cell survival and engraftment. © 2012 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/163471
ISSN
2015 Impact Factor: 3.12
2015 SCImago Journal Rankings: 1.513
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLui, KOen_US
dc.contributor.authorBu, Len_US
dc.contributor.authorLi, RAen_US
dc.contributor.authorChan, CWen_US
dc.date.accessioned2012-09-05T05:31:46Z-
dc.date.available2012-09-05T05:31:46Z-
dc.date.issued2012en_US
dc.identifier.citationBirth Defects Research Part C - Embryo Today: Reviews, 2012, v. 96 n. 1, p. 98-108en_US
dc.identifier.issn1542-975Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/163471-
dc.description.abstractHeart diseases such as myocardial infarction cause massive loss of cardiomyocytes, but the human heart lacks the innate ability to regenerate. In the adult mammalian heart, a resident progenitor cell population, termed epicardial progenitors, has been identified and reported to stay quiescent under uninjured conditions; however, myocardial infarction induces their proliferation and de novo differentiation into cardiac cells. It is conceivable to develop novel therapeutic approaches for myocardial repair by targeting such expandable sources of cardiac progenitors, thereby giving rise to new muscle and vasculatures. Human pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells can self-renew and differentiate into the three major cell types of the heart, namely cardiomyocytes, smooth muscle, and endothelial cells. In this review, we describe our current knowledge of the therapeutic potential and challenges associated with the use of pluripotent stem cell and progenitor biology in cell therapy. An emphasis is placed on the contribution of paracrine factors in the growth of myocardium and neovascularization as well as the role of immunogenicity in cell survival and engraftment. © 2012 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/102527247en_US
dc.relation.ispartofBirth Defects Research Part C - Embryo Today: Reviewsen_US
dc.subjectEscen_US
dc.subjectHeart Developmenten_US
dc.subjectImmunogenicityen_US
dc.subjectIpscen_US
dc.subjectRegenerative Medicineen_US
dc.subjectStem Cellsen_US
dc.subjectTransplantationen_US
dc.titlePluripotent stem cell-based heart regeneration: From the developmental and immunological perspectivesen_US
dc.typeArticleen_US
dc.identifier.emailBu, L:leibu@hku.hken_US
dc.identifier.emailLui, OLK: kolui@hku.hk-
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hk-
dc.identifier.emailChan, CWY: camchan@hku.hk-
dc.identifier.authorityBu, L=rp01534en_US
dc.identifier.authorityLi, RA=rp01352-
dc.identifier.authorityChan, CWY=rp01311-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/bdrc.21004en_US
dc.identifier.pmid22457181-
dc.identifier.scopuseid_2-s2.0-84859149207en_US
dc.identifier.hkuros207922-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859149207&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume96en_US
dc.identifier.issue1en_US
dc.identifier.spage98en_US
dc.identifier.epage108en_US
dc.identifier.isiWOS:000302287800008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLui, KO=55153689700en_US
dc.identifier.scopusauthoridBu, L=8510445400en_US
dc.identifier.scopusauthoridLi, RA=55153638000en_US
dc.identifier.scopusauthoridChan, CW=55152596100en_US

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