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Article: Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: Late onset and favorable response to treatment

TitlePost-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: Late onset and favorable response to treatment
Authors
KeywordsAsia
Post-Transplant Lymphoproliferative Disorders
Issue Date2012
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
Citation
Clinical Transplantation, 2012, v. 26 n. 5, p. 679-683 How to Cite?
AbstractNineteen consecutive patients with post-transplant lymphoproliferative disorders (PTLD) in an Asian population were reviewed. The histopathologic diagnoses were monomorphic (CD20-positive diffuse large B-cell lymphoma, n=14); plasmacytic (n=1); Burkitt-like (n=1); natural killer cell lymphoma (n=1); lymphomatoid papulosis (n=1); and classical Hodgkin lymphoma (n=1). Early-onset (
Persistent Identifierhttp://hdl.handle.net/10722/163455
ISSN
2015 Impact Factor: 1.844
2015 SCImago Journal Rankings: 0.821
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, TSen_US
dc.contributor.authorHwang, YYen_US
dc.contributor.authorGill, Hen_US
dc.contributor.authorAu, WYen_US
dc.contributor.authorLeung, AYen_US
dc.contributor.authorTse, Een_US
dc.contributor.authorChim, CSen_US
dc.contributor.authorLoong, Fen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:31:38Z-
dc.date.available2012-09-05T05:31:38Z-
dc.date.issued2012en_US
dc.identifier.citationClinical Transplantation, 2012, v. 26 n. 5, p. 679-683en_US
dc.identifier.issn0902-0063en_US
dc.identifier.urihttp://hdl.handle.net/10722/163455-
dc.description.abstractNineteen consecutive patients with post-transplant lymphoproliferative disorders (PTLD) in an Asian population were reviewed. The histopathologic diagnoses were monomorphic (CD20-positive diffuse large B-cell lymphoma, n=14); plasmacytic (n=1); Burkitt-like (n=1); natural killer cell lymphoma (n=1); lymphomatoid papulosis (n=1); and classical Hodgkin lymphoma (n=1). Early-onset (<oneyr post-transplantation) PTLD constituted only 10% of cases, and all were Epstein-Barr virus (EBV) positive. EBV-negative cases (n=6) developed at a median of 92 (19-170) months, whereas EBV-positive cases occurred later at 128 (7-230) months. With reduction of immunosuppression followed by local therapy, treatment with the anti-CD20 antibody rituximab with or without combination chemotherapy, complete remission was achieved in 17/19 (90%) of cases. Lactate dehydrogenase level, stage, extranodal involvement, EBV status, and International Prognostic Index had no impact on treatment outcome. EBV-positive PTLD occurred much later in Asian patients. Treatment results of PTLD were favorable. © 2012 John Wiley & Sons A/S.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTRen_US
dc.relation.ispartofClinical Transplantationen_US
dc.subjectAsiaen_US
dc.subjectPost-Transplant Lymphoproliferative Disordersen_US
dc.titlePost-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: Late onset and favorable response to treatmenten_US
dc.typeArticleen_US
dc.identifier.emailTse, E:ewctse@hku.hken_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.emailAu, WY: auwing@hkucc.hku.hk-
dc.identifier.emailLeung, AY: ayhleung@hku.hk-
dc.identifier.emailChim, CS: jcschim@hku.hk-
dc.identifier.emailLoong, F: floong@hkucc.hku.hk-
dc.identifier.authorityTse, E=rp00471en_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.identifier.authorityLeung, AY=rp00265-
dc.identifier.authorityChim, CS=rp00408-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1399-0012.2011.01593.xen_US
dc.identifier.pmid22324300-
dc.identifier.scopuseid_2-s2.0-84867656829en_US
dc.identifier.hkuros207254-
dc.identifier.isiWOS:000309917700020-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridChan, TS=41261226500en_US
dc.identifier.scopusauthoridHwang, YY=26532944100en_US
dc.identifier.scopusauthoridGill, H=36086184900en_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridLeung, AY=55091367300en_US
dc.identifier.scopusauthoridTse, E=7005019454en_US
dc.identifier.scopusauthoridChim, CS=54969632900en_US
dc.identifier.scopusauthoridLoong, F=6602794154en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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