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Article: MicroRNAs and type 2 diabetes/obesity

TitleMicroRNAs and type 2 diabetes/obesity
Authors
Dehwah, MASXu, AHuang, Q
KeywordsMicroRNAs
Obesity
Type 2 diabetes
Issue Date2012
Citation
Journal Of Genetics And Genomics, 2012, v. 39 n. 1, p. 11-18 How to Cite?
DOI: http://dx.doi.org/10.1016/j.jgg.2011.11.007
AbstractMicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes (T2D) and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications. © 2012. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China.
Persistent Identifierhttp://hdl.handle.net/10722/163451
ISSN
1673-8527
2021 Impact Factor: 5.723
2020 SCImago Journal Rankings: 1.391
ISI Accession Number ID
WOS:000299951000003
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorDehwah, MASen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorHuang, Qen_HK
dc.date.accessioned2012-09-05T05:31:32Z-
dc.date.available2012-09-05T05:31:32Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Genetics And Genomics, 2012, v. 39 n. 1, p. 11-18en_HK
dc.identifier.issn1673-8527en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163451-
dc.description.abstractMicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes (T2D) and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications. © 2012. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China.en_HK
dc.languageengen_US
dc.relation.ispartofJournal of Genetics and Genomicsen_HK
dc.subjectMicroRNAsen_HK
dc.subjectObesityen_HK
dc.subjectType 2 diabetesen_HK
dc.titleMicroRNAs and type 2 diabetes/obesityen_HK
dc.typeArticleen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailHuang, Q: qyhuang@hotmail.comen_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityHuang, Q=rp00521en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jgg.2011.11.007en_HK
dc.identifier.pmid22293113-
dc.identifier.scopuseid_2-s2.0-84856320958en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856320958&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue1en_HK
dc.identifier.spage11en_HK
dc.identifier.epage18en_HK
dc.identifier.isiWOS:000299951000003-
dc.identifier.scopusauthoridDehwah, MAS=24070520600en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridHuang, Q=7403630787en_HK
dc.identifier.issnl1873-5533-

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