Article: Obesity, obstructive sleep apnoea and metabolic syndrome

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Publisher Website: 10.1111/j.1440-1843.2011.02081.x
Scopus: eid_2-s2.0-84856240103

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Title	Obesity, obstructive sleep apnoea and metabolic syndrome
Authors	Lam, JCM1 Mak, JCW1 Ip, MSM1
Issue Date	2012
Publisher	Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
Citation	Respirology, 2012, v. 17 n. 2, p. 223-236 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1440-1843.2011.02081.x
Abstract	OSA is increasingly recognized as a major health problem in developed countries. Obesity is the most common risk factor in OSA and hence, the prevalence of OSA is undoubtedly rising given the epidemic of obesity. Recent data also suggest that OSA is highly associated with the metabolic syndrome, and it is postulated that OSA contributes to cardiometabolic dysfunction, and subsequently vasculopathy. Current evidence regarding the magnitude of impact on ultimate cardiovascular morbidity or mortality attributable to OSA-induced metabolic dysregulation is scarce. Given the known pathophysiological triggers of intermittent hypoxia and sleep fragmentation in OSA, the potential mechanisms of OSA-obesity-metabolic syndrome interaction involve sympathetic activation, oxidative stress, inflammation and neurohumoral changes. There is accumulating evidence from human and animal/cell models of intermittent hypoxia to map out these mechanistic pathways. In spite of support for an independent role of OSA in the contribution towards metabolic dysfunction, a healthy diet and appropriate lifestyle modifications towards better control of metabolic function are equally important as CPAP treatment in the holistic management of OSA. © 2011 Asian Pacific Society of Respirology.
ISSN	1323-7799 2011 Impact Factor: 2.416 2011 SCImago Journal Rankings: 0.170
DOI	http://dx.doi.org/10.1111/j.1440-1843.2011.02081.x

DC Field	Value
dc.contributor.author	Lam, JCM
dc.contributor.author	Mak, JCW
dc.contributor.author	Ip, MSM
dc.date.accessioned	2012-09-05T05:31:32Z
dc.date.available	2012-09-05T05:31:32Z
dc.date.issued	2012
dc.description.abstract	OSA is increasingly recognized as a major health problem in developed countries. Obesity is the most common risk factor in OSA and hence, the prevalence of OSA is undoubtedly rising given the epidemic of obesity. Recent data also suggest that OSA is highly associated with the metabolic syndrome, and it is postulated that OSA contributes to cardiometabolic dysfunction, and subsequently vasculopathy. Current evidence regarding the magnitude of impact on ultimate cardiovascular morbidity or mortality attributable to OSA-induced metabolic dysregulation is scarce. Given the known pathophysiological triggers of intermittent hypoxia and sleep fragmentation in OSA, the potential mechanisms of OSA-obesity-metabolic syndrome interaction involve sympathetic activation, oxidative stress, inflammation and neurohumoral changes. There is accumulating evidence from human and animal/cell models of intermittent hypoxia to map out these mechanistic pathways. In spite of support for an independent role of OSA in the contribution towards metabolic dysfunction, a healthy diet and appropriate lifestyle modifications towards better control of metabolic function are equally important as CPAP treatment in the holistic management of OSA. © 2011 Asian Pacific Society of Respirology.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Respirology, 2012, v. 17 n. 2, p. 223-236 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1440-1843.2011.02081.x
dc.identifier.doi	http://dx.doi.org/10.1111/j.1440-1843.2011.02081.x
dc.identifier.epage	236
dc.identifier.issn	1323-7799 2011 Impact Factor: 2.416 2011 SCImago Journal Rankings: 0.170
dc.identifier.issue	2
dc.identifier.scopus	eid_2-s2.0-84856240103
dc.identifier.spage	223
dc.identifier.uri	http://hdl.handle.net/10722/163450
dc.identifier.volume	17
dc.language	eng
dc.publisher	Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
dc.publisher.place	Australia
dc.relation.ispartof	Respirology
dc.title	Obesity, obstructive sleep apnoea and metabolic syndrome
dc.type	Article

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Author Affiliations

Queen Mary Hospital Hong Kong