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Article: Obesity, obstructive sleep apnoea and metabolic syndrome
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TitleObesity, obstructive sleep apnoea and metabolic syndrome
 
AuthorsLam, JCM1
Mak, JCW1
Ip, MSM1
 
Issue Date2012
 
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
 
CitationRespirology, 2012, v. 17 n. 2, p. 223-236 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1440-1843.2011.02081.x
 
AbstractOSA is increasingly recognized as a major health problem in developed countries. Obesity is the most common risk factor in OSA and hence, the prevalence of OSA is undoubtedly rising given the epidemic of obesity. Recent data also suggest that OSA is highly associated with the metabolic syndrome, and it is postulated that OSA contributes to cardiometabolic dysfunction, and subsequently vasculopathy. Current evidence regarding the magnitude of impact on ultimate cardiovascular morbidity or mortality attributable to OSA-induced metabolic dysregulation is scarce. Given the known pathophysiological triggers of intermittent hypoxia and sleep fragmentation in OSA, the potential mechanisms of OSA-obesity-metabolic syndrome interaction involve sympathetic activation, oxidative stress, inflammation and neurohumoral changes. There is accumulating evidence from human and animal/cell models of intermittent hypoxia to map out these mechanistic pathways. In spite of support for an independent role of OSA in the contribution towards metabolic dysfunction, a healthy diet and appropriate lifestyle modifications towards better control of metabolic function are equally important as CPAP treatment in the holistic management of OSA. © 2011 Asian Pacific Society of Respirology.
 
ISSN1323-7799
2013 Impact Factor: 3.495
 
DOIhttp://dx.doi.org/10.1111/j.1440-1843.2011.02081.x
 
ISI Accession Number IDWOS:000299416100005
 
DC FieldValue
dc.contributor.authorLam, JCM
 
dc.contributor.authorMak, JCW
 
dc.contributor.authorIp, MSM
 
dc.date.accessioned2012-09-05T05:31:32Z
 
dc.date.available2012-09-05T05:31:32Z
 
dc.date.issued2012
 
dc.description.abstractOSA is increasingly recognized as a major health problem in developed countries. Obesity is the most common risk factor in OSA and hence, the prevalence of OSA is undoubtedly rising given the epidemic of obesity. Recent data also suggest that OSA is highly associated with the metabolic syndrome, and it is postulated that OSA contributes to cardiometabolic dysfunction, and subsequently vasculopathy. Current evidence regarding the magnitude of impact on ultimate cardiovascular morbidity or mortality attributable to OSA-induced metabolic dysregulation is scarce. Given the known pathophysiological triggers of intermittent hypoxia and sleep fragmentation in OSA, the potential mechanisms of OSA-obesity-metabolic syndrome interaction involve sympathetic activation, oxidative stress, inflammation and neurohumoral changes. There is accumulating evidence from human and animal/cell models of intermittent hypoxia to map out these mechanistic pathways. In spite of support for an independent role of OSA in the contribution towards metabolic dysfunction, a healthy diet and appropriate lifestyle modifications towards better control of metabolic function are equally important as CPAP treatment in the holistic management of OSA. © 2011 Asian Pacific Society of Respirology.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationRespirology, 2012, v. 17 n. 2, p. 223-236 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1440-1843.2011.02081.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1440-1843.2011.02081.x
 
dc.identifier.epage236
 
dc.identifier.isiWOS:000299416100005
 
dc.identifier.issn1323-7799
2013 Impact Factor: 3.495
 
dc.identifier.issue2
 
dc.identifier.pmid21992649
 
dc.identifier.scopuseid_2-s2.0-84856240103
 
dc.identifier.spage223
 
dc.identifier.urihttp://hdl.handle.net/10722/163450
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
 
dc.publisher.placeAustralia
 
dc.relation.ispartofRespirology
 
dc.titleObesity, obstructive sleep apnoea and metabolic syndrome
 
dc.typeArticle
 
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Author Affiliations
  1. Queen Mary Hospital Hong Kong