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Article: Age- and gender-specific differences in the prognostic value of CT coronary angiography

TitleAge- and gender-specific differences in the prognostic value of CT coronary angiography
Authors
Issue Date2012
PublisherBMJ Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
Citation
Heart, 2012, v. 98 n. 3, p. 232-237 How to Cite?
AbstractOBJECTIVE: To evaluate the potential age- and gender-specific differences in the incidence and prognostic value of coronary artery disease (CAD) in patients undergoing CT coronary angiography (CTA). DESIGN AND PATIENTS: In this multicentre prospective registry study, 2432 patients (mean age 57 +/- 12, 56% male) underwent CTA for suspected CAD. Patients were stratified into four groups according to age <60 or >/=60 years and, male or female gender. MAIN OUTCOME MEASURES: A composite end point of cardiac death and non-fatal myocardial infarction. RESULTS: CTA results were normal in 991 (41%) patients, showed non-significant CAD in 761 (31%) patients and significant CAD in the remaining 680 (28%) patients. During follow-up (median 819 days, 25-75th centile 482-1142) a cardiovascular event occurred in 59 (2.4%) patients. The annualised event rate was 1.1% in the total population (men=1.3% and women=0.9%). In patients aged <60 years, the annualised event rate of male and female patients was 0.6% and 0.5%, respectively. Among patients aged >/=60 years the annualised event rate was 1.9% in male and 1.1% in female patients. Observations on CTA predicted events in male patients, both age <60 and >/=60 years and in female patients age >/=60 years (log-rank test in all groups, p<0.01). However, CTA provided limited prognostic value in female patients aged <60 years (log-rank test, p=0.45). CONCLUSIONS: After age and gender stratification, CTA findings were shown to be of limited predictive value in female patients aged <60 years as compared with male patients at any age and female patients aged >/=60 years.
Persistent Identifierhttp://hdl.handle.net/10722/163443
ISSN
2015 Impact Factor: 5.693
2015 SCImago Journal Rankings: 2.647
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYiu, KHen_US
dc.contributor.authorde Graaf, FRen_US
dc.contributor.authorSchuijf, JDen_US
dc.contributor.authorvan Werkhoven, JMen_US
dc.contributor.authorMarsan, NAen_US
dc.contributor.authorVeltman, CEen_US
dc.contributor.authorde Roos, Aen_US
dc.contributor.authorPazhenkottil, Aen_US
dc.contributor.authorKroft, LJen_US
dc.contributor.authorBoersma, Een_US
dc.contributor.authorHerzog, Ben_US
dc.contributor.authorLeung, Men_US
dc.contributor.authorMaffei, Een_US
dc.contributor.authorLeung, DYen_US
dc.contributor.authorKaufmann, PAen_US
dc.contributor.authorCademartiri, Fen_US
dc.contributor.authorBax, JJen_US
dc.contributor.authorJukema, JWen_US
dc.date.accessioned2012-09-05T05:31:25Z-
dc.date.available2012-09-05T05:31:25Z-
dc.date.issued2012en_US
dc.identifier.citationHeart, 2012, v. 98 n. 3, p. 232-237en_US
dc.identifier.issn1355-6037en_US
dc.identifier.urihttp://hdl.handle.net/10722/163443-
dc.description.abstractOBJECTIVE: To evaluate the potential age- and gender-specific differences in the incidence and prognostic value of coronary artery disease (CAD) in patients undergoing CT coronary angiography (CTA). DESIGN AND PATIENTS: In this multicentre prospective registry study, 2432 patients (mean age 57 +/- 12, 56% male) underwent CTA for suspected CAD. Patients were stratified into four groups according to age <60 or >/=60 years and, male or female gender. MAIN OUTCOME MEASURES: A composite end point of cardiac death and non-fatal myocardial infarction. RESULTS: CTA results were normal in 991 (41%) patients, showed non-significant CAD in 761 (31%) patients and significant CAD in the remaining 680 (28%) patients. During follow-up (median 819 days, 25-75th centile 482-1142) a cardiovascular event occurred in 59 (2.4%) patients. The annualised event rate was 1.1% in the total population (men=1.3% and women=0.9%). In patients aged <60 years, the annualised event rate of male and female patients was 0.6% and 0.5%, respectively. Among patients aged >/=60 years the annualised event rate was 1.9% in male and 1.1% in female patients. Observations on CTA predicted events in male patients, both age <60 and >/=60 years and in female patients age >/=60 years (log-rank test in all groups, p<0.01). However, CTA provided limited prognostic value in female patients aged <60 years (log-rank test, p=0.45). CONCLUSIONS: After age and gender stratification, CTA findings were shown to be of limited predictive value in female patients aged <60 years as compared with male patients at any age and female patients aged >/=60 years.en_US
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/en_US
dc.relation.ispartofHearten_US
dc.rightsHeart. Copyright © BMJ Publishing Group.-
dc.rightsThis article has been accepted for publication in [Heart]. The definitive copyedited, typeset version [Heart, 2012, v. 98 n. 3, p. 232-237] is available online at: www.heart.bmj.com-
dc.subject.meshCoronary Angiography - methodsen_US
dc.subject.meshCoronary Disease - complications - epidemiology - radiographyen_US
dc.subject.meshDeath, Sudden, Cardiac - epidemiology - etiologyen_US
dc.subject.meshRisk Assessment - methodsen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titleAge- and gender-specific differences in the prognostic value of CT coronary angiographyen_US
dc.typeArticleen_US
dc.identifier.emailYiu, KH: khkyiu@hku.hken_US
dc.identifier.authorityYiu, KH=rp01490en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/heartjnl-2011-300038en_US
dc.identifier.pmid21917657-
dc.identifier.scopuseid_2-s2.0-84655167163en_US
dc.identifier.hkuros205994-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84655167163&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume98en_US
dc.identifier.issue3en_US
dc.identifier.spage232en_US
dc.identifier.epage237en_US
dc.identifier.isiWOS:000298662100011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridJukema, JW=7005836769en_US
dc.identifier.scopusauthoridBax, JJ=35379683700en_US
dc.identifier.scopusauthoridCademartiri, F=7005879777en_US
dc.identifier.scopusauthoridKaufmann, PA=7201922417en_US
dc.identifier.scopusauthoridLeung, DY=7203002860en_US
dc.identifier.scopusauthoridMaffei, E=17135297500en_US
dc.identifier.scopusauthoridLeung, M=36192985100en_US
dc.identifier.scopusauthoridHerzog, B=7005862197en_US
dc.identifier.scopusauthoridBoersma, E=7102815542en_US
dc.identifier.scopusauthoridKroft, LJ=6602331868en_US
dc.identifier.scopusauthoridPazhenkottil, A=30267890200en_US
dc.identifier.scopusauthoridDe Roos, A=35241888000en_US
dc.identifier.scopusauthoridVeltman, CE=22836970700en_US
dc.identifier.scopusauthoridMarsan, NA=23035780700en_US
dc.identifier.scopusauthoridVan Werkhoven, JM=23096176500en_US
dc.identifier.scopusauthoridSchuijf, JD=6602555819en_US
dc.identifier.scopusauthoridDe Graaf, FR=25959559400en_US
dc.identifier.scopusauthoridYiu, KH=35172267800en_US

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