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Article: Hypoadiponectinemia predicts impaired endothelium-independent vasodilation in newly diagnosed type 2 diabetic patients: An 8-year prospective study

TitleHypoadiponectinemia predicts impaired endothelium-independent vasodilation in newly diagnosed type 2 diabetic patients: An 8-year prospective study
Authors
Issue Date2011
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 2011, v. 124 n. 22, p. 3607-3612 How to Cite?
AbstractBackground Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic properties. The aim of this study was to investigate whether low adiponectin levels predict the impairment of endothelial function in newly diagnosed type 2 diabetic patients in an 8-year prospective study. Methods In the prospective study, we enrolled 133 newly diagnosed type 2 diabetic patients without subclinical atherosclerosis and gave them intensive therapy; the mean treatment period was 8 years. Intensive treatment was a stepwise implementation of behavior modification and pharmacological therapy targeting hyperglycaemia, hypertension, dyslipidaemia and obesity. We measured baseline circulating adiponectin with an enzyme-linked immunosorbent assay, endothelium-dependent and -independent vasodilation by high-resolution vascular ultrasound. At year 8, 102 patients were reexamined for endothelium-dependent and -independent vasodilation. Results Sex-adjusted adiponectin level was positively correlated with endothelium-independent vasodilation both at baseline (r=0.150, P=0.043) and at year 8 (r=0.339, P=0.001), whereas no association was found between adiponectin and endothelium-dependent vasodilation. In a stepwise multivariate linear regression model, adiponectin was an independent predictor for impaired endothelium-independent vasodilation at year 8 (P=0.001). Conclusions Plasma adiponectin concentration was associated with endothelium-independent vasodilation and hypoadiponectinemia predicted the impairment of endothelium-independent vasodilation in newly diagnosed type 2 diabetic patients under multifactorial intervention. These data support the causative link of impairment of endothelium-independent vasodilation with hypoadiponectinemia.
Persistent Identifierhttp://hdl.handle.net/10722/163424
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Hen_US
dc.contributor.authorXiao, Yen_US
dc.contributor.authorLiu, Hen_US
dc.contributor.authorChen, XYen_US
dc.contributor.authorLi, XYen_US
dc.contributor.authorTang, WLen_US
dc.contributor.authorLiu, SPen_US
dc.contributor.authorXu, AMen_US
dc.contributor.authorZhou, ZGen_US
dc.date.accessioned2012-09-05T05:31:12Z-
dc.date.available2012-09-05T05:31:12Z-
dc.date.issued2011en_US
dc.identifier.citationChinese Medical Journal, 2011, v. 124 n. 22, p. 3607-3612en_US
dc.identifier.issn0366-6999en_US
dc.identifier.urihttp://hdl.handle.net/10722/163424-
dc.description.abstractBackground Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic properties. The aim of this study was to investigate whether low adiponectin levels predict the impairment of endothelial function in newly diagnosed type 2 diabetic patients in an 8-year prospective study. Methods In the prospective study, we enrolled 133 newly diagnosed type 2 diabetic patients without subclinical atherosclerosis and gave them intensive therapy; the mean treatment period was 8 years. Intensive treatment was a stepwise implementation of behavior modification and pharmacological therapy targeting hyperglycaemia, hypertension, dyslipidaemia and obesity. We measured baseline circulating adiponectin with an enzyme-linked immunosorbent assay, endothelium-dependent and -independent vasodilation by high-resolution vascular ultrasound. At year 8, 102 patients were reexamined for endothelium-dependent and -independent vasodilation. Results Sex-adjusted adiponectin level was positively correlated with endothelium-independent vasodilation both at baseline (r=0.150, P=0.043) and at year 8 (r=0.339, P=0.001), whereas no association was found between adiponectin and endothelium-dependent vasodilation. In a stepwise multivariate linear regression model, adiponectin was an independent predictor for impaired endothelium-independent vasodilation at year 8 (P=0.001). Conclusions Plasma adiponectin concentration was associated with endothelium-independent vasodilation and hypoadiponectinemia predicted the impairment of endothelium-independent vasodilation in newly diagnosed type 2 diabetic patients under multifactorial intervention. These data support the causative link of impairment of endothelium-independent vasodilation with hypoadiponectinemia.en_US
dc.languageengen_US
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/en_US
dc.relation.ispartofChinese Medical Journalen_US
dc.subject.meshAdiponectin - Blooden_US
dc.subject.meshDiabetes Mellitus, Type 2 - Blood - Physiopathologyen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshVasodilation - Physiologyen_US
dc.titleHypoadiponectinemia predicts impaired endothelium-independent vasodilation in newly diagnosed type 2 diabetic patients: An 8-year prospective studyen_US
dc.typeArticleen_US
dc.identifier.emailXu, AM:amxu@hkucc.hku.hken_US
dc.identifier.authorityXu, AM=rp00485en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.3760/cma.j.issn.0366-6999.2011.22.002en_US
dc.identifier.pmid22340211-
dc.identifier.scopuseid_2-s2.0-82255173963en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-82255173963&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume124en_US
dc.identifier.issue22en_US
dc.identifier.spage3607en_US
dc.identifier.epage3612en_US
dc.identifier.isiWOS:000297658300002-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridLi, H=54786669500en_US
dc.identifier.scopusauthoridXiao, Y=36464707600en_US
dc.identifier.scopusauthoridLiu, H=54786720800en_US
dc.identifier.scopusauthoridChen, XY=54786261500en_US
dc.identifier.scopusauthoridLi, XY=54786613200en_US
dc.identifier.scopusauthoridTang, WL=7403430885en_US
dc.identifier.scopusauthoridLiu, SP=54786690900en_US
dc.identifier.scopusauthoridXu, AM=7202655409en_US
dc.identifier.scopusauthoridZhou, ZG=21740228400en_US

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