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Article: The diagnosis and management of extranodal NK/T-cell lymphoma, nasal-type and aggressive NK-cell leukemia.

TitleThe diagnosis and management of extranodal NK/T-cell lymphoma, nasal-type and aggressive NK-cell leukemia.
Authors
Issue Date2011
Citation
Journal Of Clinical And Experimental Hematopathology : Jceh, 2011, v. 51 n. 1, p. 21-28 How to Cite?
AbstractNatural killer (NK) cell lymphomas are rare malignancies. They are classified as extranodal NK/T-cell lymphoma, nasal type, and aggressive NK cell leukemia. NK cell neoplasms are prevalent in Asian and South American populations, but are extremely rare in the West. They can be classified clinically into nasal, non-nasal, and aggressive lymphoma/leukemia subtypes. For nasal NK cell lymphomas, combined chemotherapy and radiotherapy are indicated for stage I/II disease. Chemotherapy is the main treatment for stage III/IV nasal NK cell lymphomas, as well as the non-nasal and aggressive subtypes. Regimens containing drugs not affected by the P-glycoprotein, particularly in combination with L-asparaginase, have resulted in much improvement in treatment outcome for high-risk, refractory or relapsed patients. Autologous or allogeneic hematopoietic stem cell transplantation should be considered for selected patients. Epstein-Barr virus DNA load as a surrogate marker for prognostication, and clinical stratification of patients should be incorporated in clinical management algorithms.
Persistent Identifierhttp://hdl.handle.net/10722/163409
ISSN
2015 SCImago Journal Rankings: 0.493

 

DC FieldValueLanguage
dc.contributor.authorYokLam, Ken_US
dc.date.accessioned2012-09-05T05:30:59Z-
dc.date.available2012-09-05T05:30:59Z-
dc.date.issued2011en_US
dc.identifier.citationJournal Of Clinical And Experimental Hematopathology : Jceh, 2011, v. 51 n. 1, p. 21-28en_US
dc.identifier.issn1880-9952en_US
dc.identifier.urihttp://hdl.handle.net/10722/163409-
dc.description.abstractNatural killer (NK) cell lymphomas are rare malignancies. They are classified as extranodal NK/T-cell lymphoma, nasal type, and aggressive NK cell leukemia. NK cell neoplasms are prevalent in Asian and South American populations, but are extremely rare in the West. They can be classified clinically into nasal, non-nasal, and aggressive lymphoma/leukemia subtypes. For nasal NK cell lymphomas, combined chemotherapy and radiotherapy are indicated for stage I/II disease. Chemotherapy is the main treatment for stage III/IV nasal NK cell lymphomas, as well as the non-nasal and aggressive subtypes. Regimens containing drugs not affected by the P-glycoprotein, particularly in combination with L-asparaginase, have resulted in much improvement in treatment outcome for high-risk, refractory or relapsed patients. Autologous or allogeneic hematopoietic stem cell transplantation should be considered for selected patients. Epstein-Barr virus DNA load as a surrogate marker for prognostication, and clinical stratification of patients should be incorporated in clinical management algorithms.en_US
dc.languageengen_US
dc.relation.ispartofJournal of clinical and experimental hematopathology : JCEHen_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Therapeutic Useen_US
dc.subject.meshHematopoietic Stem Cell Transplantationen_US
dc.subject.meshHumansen_US
dc.subject.meshKiller Cells, Natural - Pathologyen_US
dc.subject.meshLeukemia - Pathology - Therapyen_US
dc.subject.meshLymphoma, Extranodal Nk-T-Cell - Pathology - Therapyen_US
dc.titleThe diagnosis and management of extranodal NK/T-cell lymphoma, nasal-type and aggressive NK-cell leukemia.en_US
dc.typeArticleen_US
dc.identifier.emailYokLam, K:ylkwong@hku.hken_US
dc.identifier.authorityYokLam, K=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3960/jslrt.51.21en_US
dc.identifier.pmid21628857-
dc.identifier.scopuseid_2-s2.0-80054017714en_US
dc.identifier.volume51en_US
dc.identifier.issue1en_US
dc.identifier.spage21en_US
dc.identifier.epage28en_US
dc.identifier.scopusauthoridYokLam, K=7102818954en_US

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