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Article: Prognostic value of renal dysfunction for the prediction of outcome versus results of computed tomographic coronary angiography

TitlePrognostic value of renal dysfunction for the prediction of outcome versus results of computed tomographic coronary angiography
Authors
Issue Date2011
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
Citation
The American Journal of Cardiology, 2011, v. 108 n. 7, p. 968-972 How to Cite?
AbstractChronic kidney disease (CKD) is associated with cardiovascular (CV) events caused by advanced atherosclerosis. Computed tomographic coronary angiography (CTA) can accurately diagnose coronary artery disease (CAD) and predict CV outcomes. The aim of the present study was to evaluate whether moderate CKD provides prognostic information for CV events in patients undergoing CTA. In total 885 patients with suspected CAD underwent CTA and were stratified to moderate CKD (85 patients) or no CKD (770 patients) based on a cut-off estimated glomerular filtration rate of 60 ml/min/1.73 m(2). After 896 days of follow-up, 42 patients developed CV events. Annualized CV event rates were 1.2% in patients with no CKD and no CAD, 2.5% in patients with moderate CKD alone, 2.5% in patients with obstructive CAD alone, and 3.7% in those with moderate CKD and obstructive CAD. Multivariate models demonstrated that moderate CKD (hazard ratio 2.39, confidence interval 1.09 to 5.21, p = 0.03) and obstructive CAD (hazard ratio 2.76, confidence interval 1.40 to 5.44, p <0.01) were independent predictors of CV events. Importantly, moderate CKD provided incremental prognostic information in addition to clinical characteristics and obstructive CAD (chi-square 49.4, p = 0.04). In conclusion, moderate CKD was associated with CV events and provided incremental prognostic information.
Persistent Identifierhttp://hdl.handle.net/10722/163397
ISSN
2015 Impact Factor: 3.154
2015 SCImago Journal Rankings: 2.063
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYiu, KHen_US
dc.contributor.authorde Graaf, FRen_US
dc.contributor.authorSchuijf, JDen_US
dc.contributor.authorvan Werkhoven, JMen_US
dc.contributor.authorvan Velzen, JEen_US
dc.contributor.authorBoogers, MJen_US
dc.contributor.authorRoos, CJen_US
dc.contributor.authorde Bie, MKen_US
dc.contributor.authorPazhenkottil, Aen_US
dc.contributor.authorKroft, LJen_US
dc.contributor.authorBoersma, Een_US
dc.contributor.authorHerzog, Ben_US
dc.contributor.authorde Roos, Aen_US
dc.contributor.authorKaufmann, PAen_US
dc.contributor.authorBax, JJen_US
dc.contributor.authorJukema, JWen_US
dc.date.accessioned2012-09-05T05:30:53Z-
dc.date.available2012-09-05T05:30:53Z-
dc.date.issued2011en_US
dc.identifier.citationThe American Journal of Cardiology, 2011, v. 108 n. 7, p. 968-972en_US
dc.identifier.issn0002-9149en_US
dc.identifier.urihttp://hdl.handle.net/10722/163397-
dc.description.abstractChronic kidney disease (CKD) is associated with cardiovascular (CV) events caused by advanced atherosclerosis. Computed tomographic coronary angiography (CTA) can accurately diagnose coronary artery disease (CAD) and predict CV outcomes. The aim of the present study was to evaluate whether moderate CKD provides prognostic information for CV events in patients undergoing CTA. In total 885 patients with suspected CAD underwent CTA and were stratified to moderate CKD (85 patients) or no CKD (770 patients) based on a cut-off estimated glomerular filtration rate of 60 ml/min/1.73 m(2). After 896 days of follow-up, 42 patients developed CV events. Annualized CV event rates were 1.2% in patients with no CKD and no CAD, 2.5% in patients with moderate CKD alone, 2.5% in patients with obstructive CAD alone, and 3.7% in those with moderate CKD and obstructive CAD. Multivariate models demonstrated that moderate CKD (hazard ratio 2.39, confidence interval 1.09 to 5.21, p = 0.03) and obstructive CAD (hazard ratio 2.76, confidence interval 1.40 to 5.44, p <0.01) were independent predictors of CV events. Importantly, moderate CKD provided incremental prognostic information in addition to clinical characteristics and obstructive CAD (chi-square 49.4, p = 0.04). In conclusion, moderate CKD was associated with CV events and provided incremental prognostic information.en_US
dc.languageengen_US
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/en_US
dc.relation.ispartofThe American Journal of Cardiologyen_US
dc.subject.meshAtherosclerosis - complications - epidemiology - radiographyen_US
dc.subject.meshCoronary Angiography - methodsen_US
dc.subject.meshCoronary Artery Disease - radiographyen_US
dc.subject.meshKidney Failure, Chronic - diagnosis - epidemiology - etiologyen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titlePrognostic value of renal dysfunction for the prediction of outcome versus results of computed tomographic coronary angiographyen_US
dc.typeArticleen_US
dc.identifier.emailYiu, KH: khkyiu@hku.hken_US
dc.identifier.emailJukema, JW: J.W.jukema@lumc.nl-
dc.identifier.authorityYiu, KH=rp01490en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.amjcard.2011.05.031en_US
dc.identifier.pmid21784394-
dc.identifier.scopuseid_2-s2.0-80052721811en_US
dc.identifier.hkuros205932-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052721811&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume108en_US
dc.identifier.issue7en_US
dc.identifier.spage968en_US
dc.identifier.epage972en_US
dc.identifier.isiWOS:000295863200012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJukema, JW=7005836769en_US
dc.identifier.scopusauthoridBax, JJ=35379683700en_US
dc.identifier.scopusauthoridKaufmann, PA=7201922417en_US
dc.identifier.scopusauthoridDe Roos, A=35241888000en_US
dc.identifier.scopusauthoridHerzog, B=7005862197en_US
dc.identifier.scopusauthoridBoersma, E=7102815542en_US
dc.identifier.scopusauthoridKroft, LJ=6602331868en_US
dc.identifier.scopusauthoridPazhenkottil, A=30267890200en_US
dc.identifier.scopusauthoridDe Bie, MK=24724082700en_US
dc.identifier.scopusauthoridRoos, CJ=36502679100en_US
dc.identifier.scopusauthoridBoogers, MJ=26026775200en_US
dc.identifier.scopusauthoridVan Velzen, JE=25959736900en_US
dc.identifier.scopusauthoridVan Werkhoven, JM=23096176500en_US
dc.identifier.scopusauthoridSchuijf, JD=6602555819en_US
dc.identifier.scopusauthoridDe Graaf, FR=25959559400en_US
dc.identifier.scopusauthoridYiu, KH=35172267800en_US

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