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Article: Long-term oral nitrate therapy is associated with adverse outcome in diabetic patients following elective percutaneous coronary intervention.

TitleLong-term oral nitrate therapy is associated with adverse outcome in diabetic patients following elective percutaneous coronary intervention.
Authors
Issue Date2011
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cardiab.com/
Citation
Cardiovascular Diabetology, 2011, v. 10, article no. 52 How to Cite?
AbstractTo assess the impact of long-term oral nitrate therapy on clinical outcome following percutaneous coronary intervention (PCI) in patients with type II diabetes. The incidence of major adverse cardiovascular events (MACEs) following elective PCI for stable coronary artery disease was evaluated in 108 patients with type II diabetes (age 64.6±10.5 years, 67.7% men). Major adverse cardiovascular events were defined as the need for revascularization, non-fatal myocardial infarction or cardiovascular death. Multivariate Cox regression analysis was used to evaluate the predictive value of MACEs by clinical characteristics and the prescription of long-term nitrate therapy. Isosorbide mononitrate (ISMN) was prescribed to 46 patients with an average dose of 44.3±15.2 mg/day. After a mean follow up of 25.3±25 months, 16 patients developed MACEs. Patients who received ISMN were more likely to suffer from MACEs (26.1% vs. 6.5%, P=0.01), mainly driven by a higher rate of acute coronary syndrome (13.0 vs 0%, P=0.01). Average daily dose of nitrate and other cardiovascular medication was not associated with MACEs. Multivariate Cox regression analysis revealed that prescription of only ISMN (Hazard Ratio 3.09, 95% CI 1.10-10.21, P=0.04) was an independent predictor for the development of MACEs. Long-term oral nitrate therapy was associated with MACEs following elective coronary artery revascularization by PCI in patients with type II diabetes.
Persistent Identifierhttp://hdl.handle.net/10722/163396
ISSN
2015 Impact Factor: 4.534
2015 SCImago Journal Rankings: 1.757
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYiu, KHen_US
dc.contributor.authorPong, Ven_US
dc.contributor.authorSiu, CWen_US
dc.contributor.authorLau, CPen_US
dc.contributor.authorTse, HFen_US
dc.date.accessioned2012-09-05T05:30:52Z-
dc.date.available2012-09-05T05:30:52Z-
dc.date.issued2011en_US
dc.identifier.citationCardiovascular Diabetology, 2011, v. 10, article no. 52en_US
dc.identifier.issn1475-2840en_US
dc.identifier.urihttp://hdl.handle.net/10722/163396-
dc.description.abstractTo assess the impact of long-term oral nitrate therapy on clinical outcome following percutaneous coronary intervention (PCI) in patients with type II diabetes. The incidence of major adverse cardiovascular events (MACEs) following elective PCI for stable coronary artery disease was evaluated in 108 patients with type II diabetes (age 64.6±10.5 years, 67.7% men). Major adverse cardiovascular events were defined as the need for revascularization, non-fatal myocardial infarction or cardiovascular death. Multivariate Cox regression analysis was used to evaluate the predictive value of MACEs by clinical characteristics and the prescription of long-term nitrate therapy. Isosorbide mononitrate (ISMN) was prescribed to 46 patients with an average dose of 44.3±15.2 mg/day. After a mean follow up of 25.3±25 months, 16 patients developed MACEs. Patients who received ISMN were more likely to suffer from MACEs (26.1% vs. 6.5%, P=0.01), mainly driven by a higher rate of acute coronary syndrome (13.0 vs 0%, P=0.01). Average daily dose of nitrate and other cardiovascular medication was not associated with MACEs. Multivariate Cox regression analysis revealed that prescription of only ISMN (Hazard Ratio 3.09, 95% CI 1.10-10.21, P=0.04) was an independent predictor for the development of MACEs. Long-term oral nitrate therapy was associated with MACEs following elective coronary artery revascularization by PCI in patients with type II diabetes.en_US
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cardiab.com/en_US
dc.relation.ispartofCardiovascular Diabetologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAgeden_US
dc.subject.meshAngioplasty, Balloon, Coronary - Adverse Effects - Mortalityen_US
dc.subject.meshCardiovascular Diseases - Etiology - Mortalityen_US
dc.subject.meshCoronary Artery Disease - Complications - Mortality - Therapyen_US
dc.subject.meshDiabetes Mellitus, Type 2 - Complications - Mortalityen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshIsosorbide Dinitrate - Administration & Dosage - Adverse Effects - Analogs & Derivativesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Infarction - Etiologyen_US
dc.subject.meshProportional Hazards Modelsen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVasodilator Agents - Administration & Dosage - Adverse Effectsen_US
dc.titleLong-term oral nitrate therapy is associated with adverse outcome in diabetic patients following elective percutaneous coronary intervention.en_US
dc.typeArticleen_US
dc.identifier.emailYiu, KH:khkyiu@hku.hken_US
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_US
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_US
dc.identifier.authorityYiu, KH=rp01490en_US
dc.identifier.authoritySiu, CW=rp00534en_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1186/1475-2840-10-52en_US
dc.identifier.pmid21668965en_US
dc.identifier.scopuseid_2-s2.0-79959873229en_US
dc.identifier.hkuros187312-
dc.identifier.hkuros201289-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79959873229&selection=ref&src=s&origin=recordpage-
dc.identifier.volume10en_US
dc.identifier.spage52en_US
dc.identifier.isiWOS:000292385500001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYiu, KH=35172267800en_US
dc.identifier.scopusauthoridPong, V=26025247300en_US
dc.identifier.scopusauthoridSiu, CW=7006550690en_US
dc.identifier.scopusauthoridLau, CP=7401968501en_US
dc.identifier.scopusauthoridTse, HF=7006070805en_US
dc.identifier.citeulike9432702-

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