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Article: Biophysical characterization of hematopoietic cells from normal and leukemic sources with distinct primitiveness

TitleBiophysical characterization of hematopoietic cells from normal and leukemic sources with distinct primitiveness
Authors
Issue Date2011
PublisherAmerican Institute of Physics. The Journal's web site is located at http://apl.aip.org/
Citation
Applied Physics Letters, 2011, v. 99 n. 8 How to Cite?
AbstractThis letter reported the biophysical characterization of immunophenotypically distinct hematopoietic cells from normal and leukemic sources, through manipulation with optical tweezers at single cell level. The results show that the percentage of cells that are stretchable and their deformability are significantly higher in the more primitive cell populations. This study provides the evidence that normal and leukemic hematopoietic cell populations with distinct primitiveness exhibit differential biophysical properties. These findings raise a hypothesis that the high deformability may be related to the unique functions and activities of primitive hematopoietic cells. © 2011 American Institute of Physics.
Persistent Identifierhttp://hdl.handle.net/10722/163393
ISSN
2015 Impact Factor: 3.142
2015 SCImago Journal Rankings: 1.105
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, Yen_US
dc.contributor.authorFung, TKen_US
dc.contributor.authorWan, Hen_US
dc.contributor.authorWang, Ken_US
dc.contributor.authorLeung, AYHen_US
dc.contributor.authorSun, Den_US
dc.date.accessioned2012-09-05T05:30:52Z-
dc.date.available2012-09-05T05:30:52Z-
dc.date.issued2011en_US
dc.identifier.citationApplied Physics Letters, 2011, v. 99 n. 8en_US
dc.identifier.issn0003-6951en_US
dc.identifier.urihttp://hdl.handle.net/10722/163393-
dc.description.abstractThis letter reported the biophysical characterization of immunophenotypically distinct hematopoietic cells from normal and leukemic sources, through manipulation with optical tweezers at single cell level. The results show that the percentage of cells that are stretchable and their deformability are significantly higher in the more primitive cell populations. This study provides the evidence that normal and leukemic hematopoietic cell populations with distinct primitiveness exhibit differential biophysical properties. These findings raise a hypothesis that the high deformability may be related to the unique functions and activities of primitive hematopoietic cells. © 2011 American Institute of Physics.en_US
dc.languageengen_US
dc.publisherAmerican Institute of Physics. The Journal's web site is located at http://apl.aip.org/en_US
dc.relation.ispartofApplied Physics Lettersen_US
dc.titleBiophysical characterization of hematopoietic cells from normal and leukemic sources with distinct primitivenessen_US
dc.typeArticleen_US
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_US
dc.identifier.authorityLeung, AYH=rp00265en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1063/1.3610938en_US
dc.identifier.scopuseid_2-s2.0-80052425351en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052425351&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume99en_US
dc.identifier.issue8en_US
dc.identifier.isiWOS:000294359100089-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTan, Y=26028707000en_US
dc.identifier.scopusauthoridFung, TK=7102715924en_US
dc.identifier.scopusauthoridWan, H=50761359000en_US
dc.identifier.scopusauthoridWang, K=37562173800en_US
dc.identifier.scopusauthoridLeung, AYH=7403012668en_US
dc.identifier.scopusauthoridSun, D=7403968591en_US

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